Pro-Apoptotic Activity of Novel 4-Anilinoquinazoline Derivatives Mediated by Up-Regulation of Bax and Activation of Poly(ADP-ribose) Phosphatase in Ehrlich Ascites Carcinoma Cells

Acid catalysed cyclization of o‐aminobenzamide and α‐oxodithioesters in a highly regioselective fashion to give 2‐aroylquinazolin‐4(3H)‐ones and 2‐aroyl‐4H‐benzo[d][1,3]thiazin‐4‐ones by switching the reaction medium from DMF to acetic acid. Further, the generality of the stabilised protocols was tested with various functionalities. The range of yields for the quinazolinones and 1,3‐thiazinone are 57–67 % and 70–81 %, respectively. Probable mechanisms for the formation of the two series of products are proposed from control experiments.

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Acid‐Catalysed Cyclization ofo‐Aminobenzamide withα‐Oxodithioesters: A Divergent and Regioselective Synthesis of Quinazolinones and 1,3‐Benzothiazinones

Kiran

Swaroop

Preetham

et al. 2023

ChemistrySelect

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Crystal structure, anti-Trypanosoma cruzi and cytotoxic activities of Cu(II) complexes bearing β-diketone and α-diimine ligands

Paixão

Oliveira

Almeida

et al. 2020

Inorganica Chimica Acta

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Angio-Suppressive Effect of Partially Purified Lectin-like Protein fromMusa acuminata pseudostemby Inhibition of VEGF-Mediated Neovascularization and Induces Apoptosis Both In Vitro and In Vivo

Srinivas¹,

Shivamadhu

Jayarama³

2018

Nutrition and Cancer

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Pro-Apoptotic Activity of Novel 4-Anilinoquinazoline Derivatives Mediated by Up-Regulation of Bax and Activation of Poly(ADP-ribose) Phosphatase in Ehrlich Ascites Carcinoma Cells

Cited by 6 publications

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Acid‐Catalysed Cyclization ofo‐Aminobenzamide withα‐Oxodithioesters: A Divergent and Regioselective Synthesis of Quinazolinones and 1,3‐Benzothiazinones

Acid‐Catalysed Cyclization ofo‐Aminobenzamide withα‐Oxodithioesters: A Divergent and Regioselective Synthesis of Quinazolinones and 1,3‐Benzothiazinones

Crystal structure, anti-Trypanosoma cruzi and cytotoxic activities of Cu(II) complexes bearing β-diketone and α-diimine ligands

Angio-Suppressive Effect of Partially Purified Lectin-like Protein fromMusa acuminata pseudostemby Inhibition of VEGF-Mediated Neovascularization and Induces Apoptosis Both In Vitro and In Vivo

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