Pro-apoptotic activity of ruthenium 1-methylimidazole complex on non-small cell lung cancer

Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

“…Our results showed that hmxbato induced A549 cell death by apoptosis in approximately half of the treated cells. Once again, this corroborate other studies described in the literature that also showed A549 cell death by apoptosis after treatment with different ruthenium complexes 29,32,35,49 . We further demonstrated that 3.8 µM hmxbato only induced a small percentage of death in non-tumor cells, maintaining more than 85% of viable cells.…”

“…In contrast, BEAS-2B cells survived and later formed colonies, except for cells treated with the highest concentration (19 µM) of the complex. Other studies using ruthenium complexes and A549 cells also demonstrated this interference in colony formation 29,35 , but the concentrations of the complexes required for this effect were higher than those described for hmxbato.…”

Ruthenium(ii) complex containing cinnamic acid derivative inhibits cell cycle progression at G0/G1 and induces apoptosis in melanoma cells

“…The antitumor potential of ruthenium( ii ) complexes with natural ligands has been explored in previous studies. 14–17 A ruthenium( ii ) complex containing piperonylic acid as a ligand, [Ru(pipe)(dppb)(bipy)]PF 6 , inhibited proliferation of non-small cell lung cancer A549 cells. This compound displayed higher activity compared to the precursor and the free ligand.…”

Estudo dos mecanismos de morte induzidos pelo complexo de rutênio hmxbato (cis-[RuII((ŋ2-O2CC7H7O2)(dppm)2]PF6) com atividade contra Leishmania (Leishmania) amazonensis e células tumorais de pulmão – A549

“…Algumas quimioterapias, tais como doxorrubicina e cisplatina, utilizadas para o tratamento de certos tipos de cânceres, são capazes de promover um aumento nos níveis de ERO's, o qual contribuiria para a toxicidade nas células (CONKLIN, 2004;MARULLO et al, 2013 (CHEN et al, 2019;DIAS et al, 2018;MOHAMED SUBARKHAN et al, 2019;SILVA et al, 2018). Entretanto, além disso, nós ainda demonstramos que o hmxbato na concentração de 3,8 µM induziu uma porcentagem reduzida de células normais para a morte celular, mantendo mais de 85% das células em condições viáveis.…”

“…Estudos têm demonstrado que compostos lipofílicos de rutênio são capazes de se acumular nas mitocôndrias, podendo induzir a processos apoptóticos por meio da ativação da via intrínseca. Desta forma, vários estudos envolvendo a atividade antitumoral e alguns envolvendo a atividade anti-leishmania têm demonstrado o envolvimento da mitocondria no processo de morte destes organismos celulares (CHEN et al, 2016;COSTA et al, 2019;DIAS et al, 2018;INIGUEZ et al, 2016;JIANG et al, 2019a Figura 6: Esquema de ativação das caspases por meio da via extrínseca e intrínseca. A apoptose pode ser executada através de duas vias, a via extrínseca ou via intrínseca.…”