2018
DOI: 10.1007/s12272-018-1038-y
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Pro-apoptotic peptides-based cancer therapies: challenges and strategies to enhance therapeutic efficacy

Abstract: Cancer is a leading cause of death worldwide. Despite many advances in the field of cancer therapy, an effective cure is yet to be found. As a more potent alternative for the conventional small molecule anti-cancer drugs, pro-apoptotic peptides have emerged as a new class of anticancer agents. By interaction with certain members in the apoptotic pathways, they could effectively kill tumor cells. However, there remain bottleneck challenges for clinical application of these pro-apoptotic peptides in cancer thera… Show more

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Cited by 23 publications
(19 citation statements)
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“…A number of these AMPs are based on a periodicity of lysine residues alternating with alanine and leucine residues that is designed to optimize the levels of amphiphilicity and α-helicity of the parent structure (LAK AMPs) 51 . The use of these residues minimises production costs and LAK AMPs have been employed in a number of capacities, ranging from serving as the membrane disrupting domain of targeted pro-apoptotic peptides 52 to enhancing the antimicrobial action of sonosensitizers when conjugated with these molecules 53 . LAK AMPs also serve as potent, broad range antibacterial agents 51 In general, the interaction of AMPs with the bacterial membrane leads to the death of these organisms via membranolysis and a number of models have been presented to describe this process, such as the barrel stave, toroidal pore, carpet and tilted-type mechanisms 37 .…”
Section: Discussionmentioning
confidence: 99%
“…A number of these AMPs are based on a periodicity of lysine residues alternating with alanine and leucine residues that is designed to optimize the levels of amphiphilicity and α-helicity of the parent structure (LAK AMPs) 51 . The use of these residues minimises production costs and LAK AMPs have been employed in a number of capacities, ranging from serving as the membrane disrupting domain of targeted pro-apoptotic peptides 52 to enhancing the antimicrobial action of sonosensitizers when conjugated with these molecules 53 . LAK AMPs also serve as potent, broad range antibacterial agents 51 In general, the interaction of AMPs with the bacterial membrane leads to the death of these organisms via membranolysis and a number of models have been presented to describe this process, such as the barrel stave, toroidal pore, carpet and tilted-type mechanisms 37 .…”
Section: Discussionmentioning
confidence: 99%
“…They have many biological functions, including anti-oxidation, anti-proliferation, and the inhibition of tubulin polymerization and cytotoxicity. The functions of these peptides show that they have the potential to be used in cancer treatment 6-8. There are various kinds of bioactive peptides that possess different biological functions and have close relationships with many regulation systems in the human body.…”
Section: Introductionmentioning
confidence: 99%
“…This NH2-terminal 20 amino acid peptide of the influenza virus haemagglutinin-2 protein (HA-2) with its pH-based fusogenicity got the entrapped 11R-p53 to be released from macropinosome so that the molecule could swim right through towards the target region, and got fused with the mt-p53 C-terminus at pH 5, thus turning on the latent p53 protein to action. 43,[49][50][51]…”
Section: Non-viral Methodsmentioning
confidence: 99%