Pro-atherogenic cytokine profile of patients with suspected obstructive sleep apnea

Abstract

We did not find significant associations between OSA and markers of activated innate immunity (IL-1B, 6, and 8). However, OSA severity was independently associated with serum levels of sVCAM-1 and leptin; these may represent mechanisms involved in the pathogenesis of OSA-related CVD.

The role inflammatory response genes in obstructive sleep apnea syndrome: a review

“…In OSAS patients, several inflammatory factors can be found in high concentrations, which can be used as biological markers [32], such as interleukin-6 (IL-6) [33], interleukin-8 (IL-8) [34,35], tumor necrosis factor-α (TNF-α) [35], vascular endothelial growth factor (VEGF) [36], leptine [37,38], and C-reactive protein (CRP) [39,40].…”

Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS)

“…The levels of the pro-inflammatory cytokine TNF-α are correlated with the severity of OSAS. TNF-α modulates physiological sleep [88] [97][98][99]. Nevertheless, Zhang and co-workers have recently showed that genetic variants of the IL-6 gene confer different susceptibility to develop OSAS, thus suggesting a potential approach to assess the risk for OSAS [100].…”

Association of Serum YKL-40 With the Presence and Severity of Obstructive Sleep Apnea Syndrome

“…The presence of systemic inflammation in OSAS is supported by elevated levels of circulating inflammatory markers including C-reactive protein, interleukin-6 (IL-6), IL-8, and tumor necrosis factor-α (TNF-α). 4 Several studies have verified the presence of inflammation in the nasal mucosa, uvula, soft palate, and pharyngolaryngeal tract of OSAS patients, which indicates that upper airway inflammation is correlated with OSAS. 10,11 Furthermore, there is clinical 13 and pneumonia.…”