Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up

Fatemi, Shahab; Acosta, Stefan; Zarrouk, Moncef; Engström, Gunnar; Melander, Olle; Gottsäter, Anders

doi:10.1016/j.jstrokecerebrovasdis.2020.105403

Cited by 6 publications

(6 citation statements)

References 57 publications

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“…Cystatin C reflecting kidney function has also been cross-sectionally associated with CAS [11]. We recently reported that NT pro-BNP and MR-proADM were strong indicators of incident CAS [12]. The aim of this study was to determine whether the predictive values of plasma biomarker levels adjusted for conventional risk factors are different in symptomatic CAS for which surgery is clearly indicated [2, 3] and in asymptomatic CAS where the indication for surgery is debatable.…”

Section: Introductionmentioning

confidence: 99%

Circulating Biomarkers Predict Symptomatic but Not Asymptomatic Carotid Artery Stenosis

et al. 2022

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Background: Subjects exposed to risk factors such as age, gender, hypertension, diabetes mellitus, and smoking are prone to atherosclerotic events. Aims: The main aim of this longitudinal cohort study was to determine whether the role of novel plasma biomarkers for atherosclerotic carotid artery disease is different in subjects developing symptomatic carotid artery stenosis (CAS), as opposed to those with incident asymptomatic CAS. Methods: The following biomarkers were measured in 5,550 middle-aged subjects in a population-based cohort study: C-reactive protein (CRP), lipoprotein-associated phospholipase A2 mass and activity, proneurotensin, midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide (MR-proANP), N-terminal pro-B-type natriuretic peptide (NT pro-BNP), copeptin, and cystatin C. After exclusion of those with prevalent CAS, subjects were thereafter followed in national patient registers for 23.4 (interquartile range 19.5–24.3) years regarding incident symptomatic and asymptomatic CAS. Results: Among 110 patients with confirmed incident CAS, 56 were symptomatic and 54 were asymptomatic. When including conventional risk markers in a Cox regression analysis, NT pro-BNP (hazard ratio [HR] 1.59; 95% confidence interval [CI]: 1.20–2.11), MR-proADM (HR 1.40; CI: 1.13–1.73), cystatin C (HR 1.21; CI: 1.02–1.43), and CRP (HR 1.53; CI: 1.13–1.73) were independently associated with incident symptomatic CAS, whereas no plasma biomarker was associated with incident asymptomatic CAS. Conclusion: Plasma biomarkers NT pro-BNP, MR-proADM, cystatin C, and CRP were independently associated with incident symptomatic CAS, whereas no such association could be demonstrated with incident asymptomatic CAS. As these biomarkers indicate future development of clinically relevant atherosclerotic CAS, their potential utility in relation to intensified preventive measures and selection of potential candidates for carotid surgery should be further evaluated.

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Section: Introductionmentioning

confidence: 99%

Circulating Biomarkers Predict Symptomatic but Not Asymptomatic Carotid Artery Stenosis

et al. 2022

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“…NT-proBNP has the advantages of long half-life and high stability, and its clinical significance is equivalent to BNP (brain natriuretic peptide). [20][21][22][23][24][25] The level of blood BNP reflects the heart function of the patient. BNP .400 pg/mL is However, in this study, the postoperative NT-proBNP level was significantly lower in the test group than in the control group, demonstrating that the cardiac function of the patients was better in the test group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…NT-proBNP has the advantages of long half-life and high stability, and its clinical significance is equivalent to BNP (brain natriuretic peptide). 20–25 The level of blood BNP reflects the heart function of the patient. BNP >400 pg/mL is regarded as heart failure in the European Heart Association guidelines.…”

Section: Discussionmentioning

confidence: 99%

Effects of Spironolactone on Hypoxia-Inducible Factor-1α in the Patients Receiving Coronary Artery Bypass Grafting

Lou

Zheng

Xie

et al. 2021

Journal of Cardiovascular Pharmacology

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:We explored the protective effect of spironolactone on cardiac function in the patients undergoing coronary artery bypass grafting (CABG) by determining serum hypoxia-inducible factor-1α (HIF-1α) before and after CABG. We used the propensity score matching method retrospectively to select 174 patients undergoing CABG in our hospital from March 2018 to December 2019. Of the 174 patients, 87 patients taking spironolactone for more than 3 months before CABG were used as a test group and other 87 patients who were not taking spironolactone as a control group. In all patients, serum HIF-1α and troponin I levels were determined before as well as 24 hours and 7 days after CABG, serum N-terminal probrain natriuretic peptide (NT-proBNP) level was determined before as well as 12, 24, and 36 hours after CABG, and electrocardiographic monitoring was performed within 36 hours after CABG. The results indicated that there were no significant differences in the HIF-1α level between the test group and the control group before and 7 days after CABG, but the HIF-1α level was significantly lower in the test group than that in the control group 24 hours after CABG (P < 0.01). The 2 groups were not significantly different in the troponin I level at any time point. There was no significant difference in the serum NT-proBNP level between the test group and the control group before CABG, but NT-proBNP (BNP) levels were all significantly lower in the test group than those in the control group at postoperative 12, 24, and 36 hour time points (all P <0.05). The incidence of postoperative atrial fibrillation was also significantly lower in the test group than that in the control group (P = 0.035). Spironolactone protects cardiac function probably by improving myocardial hypoxia and inhibiting myocardial remodeling.

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“…Increased levels of Lp-PLA 2 have been associated with the early development of both peripheral arterial disease ( 13 ) and AAA ( 14 ). The hemodynamic plasma biomarker B-type natriuretic peptide has also been associated with both an early subclinical development of peripheral ( 15 ) and carotid ( 16 ) artery disease and AAA ( 17 ) decades before clinical manifestation in individuals free from disease. A biomarker of neurohormonal activation, mid-regional-pro-adrenomedullin (MR-proADM), has also been associated with the prediction of both carotid artery disease ( 16 ) and AAA ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

“…The hemodynamic plasma biomarker B-type natriuretic peptide has also been associated with both an early subclinical development of peripheral ( 15 ) and carotid ( 16 ) artery disease and AAA ( 17 ) decades before clinical manifestation in individuals free from disease. A biomarker of neurohormonal activation, mid-regional-pro-adrenomedullin (MR-proADM), has also been associated with the prediction of both carotid artery disease ( 16 ) and AAA ( 18 ). It appears that these biomarkers reflect the early onset of cardiovascular disease, reacting to either slow development of peripheral arterial atherosclerotic stenosis and/or abdominal aortic wall degeneration and aneurysm development.…”

Section: Introductionmentioning

confidence: 99%

Prospective Comparison of Plasma Biomarker and Traditional Risk Factor Profiles for Incident Isolated Atherosclerotic Disease and Incident Isolated Abdominal Aortic Aneurysm

Acosta

Fatemi

Melander

et al. 2022

Front. Cardiovasc. Med.

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Background: Traditional risk factors for atherosclerotic disease (AD) are well-known, of which some are relevant also for abdominal aortic aneurysms (AAA). The present study compares the importance of plasma biomarkers and traditional risk factor profiles for incident AD without concomitant AAA (isolated AD) and AAA without concomitant AD (isolated AAA) during long-term follow-up.Methods: In the Malmö Diet and Cancer Study—cardiovascular cohort, 5,381 participants were free from atrial fibrillation or flutter, AD (coronary artery disease, atherothrombotic ischemic stroke, carotid artery disease, or peripheral artery disease), and AAA underwent blood sampling under standardized fasting conditions between 1991 and 1994. Cox proportional hazards regression analysis was used to calculate hazard ratios (HR) with 95% CIs.Results: During a median follow-up of 23.1 years, 1,152 participants developed isolated AD, and 44 developed isolated AAA. Adjusted HR for lipoprotein-associated phospholipase A2 (mass) (HR 1.53, 95% CI 1.14–2.04 vs. HR 1.05, 95% CI.99–1.12) was higher for incident isolated AAA compared to incident isolated AD, respectively. Mid-regional pro-adrenomedullin (MR-proADM) was associated with incident isolated AD (HR 1.17, 95% CI 1.1–1.25) and incident isolated AAA (HR 1.47, 95% CI 1.15–1.88). MR-proADM was correlated (r = 0.32; p < 0.001) to body mass index (BMI), and BMI was associated with increased risk of incident isolated AAA (HR 1.43, 95% CI 1.02–2). No participant with diabetes mellitus (DM) at baseline developed isolated AAA (0/44), whereas DM was associated with an increased risk of isolated AD (HR 2.57, 95% CI 2.08–3.18). Adjusted HR for male sex (HR 4.8, 95% CI 2.42–9.48, vs. HR 1.76, 95% CI 1.56–1.98) and current smoking (HR 4.79, 95% CI 2.42–9.47 vs. HR 1.97, 95% CI 1.73–2.23) were higher in the incident isolated AAA group compared to the incident isolated AD group, respectively.Conclusions: The data supports the view that components of vascular inflammation and cardiovascular stress drives AAA development, whereas glycated cross-links in abdominal aortic wall tissue may have a plausible role in reducing AAA risk in individuals with DM.

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Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up

Cited by 6 publications

References 57 publications

Circulating Biomarkers Predict Symptomatic but Not Asymptomatic Carotid Artery Stenosis

Circulating Biomarkers Predict Symptomatic but Not Asymptomatic Carotid Artery Stenosis

Effects of Spironolactone on Hypoxia-Inducible Factor-1α in the Patients Receiving Coronary Artery Bypass Grafting

Prospective Comparison of Plasma Biomarker and Traditional Risk Factor Profiles for Incident Isolated Atherosclerotic Disease and Incident Isolated Abdominal Aortic Aneurysm

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