Pro: does shockwave therapy have a place in the treatment of Peyronie’s disease?

Chung, Eric

doi:10.21037/tau.2016.03.26

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…The initial histopathologic and macroscopic manifestation of crystal deposition is visualized as Randall's plaques 9,15,16 . These are micro-and macroscopic deposits of calcium that originate in the basement membrane of the loop of Henle, which extend into the interstitium below the urothelium of the renal papilla 17,18 .…”

Section: Calculi Formation Mechanismmentioning

confidence: 99%

Metabolic studies and calculi analysis in urinary lithiasis, how to stop recurrence?

Barco‐Castillo¹,

Uribe²,

Bohórquez³

et al. 2023

RUC

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al cólico renoureteral. Las complicaciones incluyen hematuria, anuria debido a la obstrucción bilateral o unilateral en el riñón solitario y la sepsis. La recurrencia ocurre en hasta el 50% de los pacientes después de 5 años desde el primer episodio, y aquellos paciente requieren estudios metabólicos y análisis del cálculo. El manejo farmacológico y las modificaciones dietéticas evitarán nuevos episodios. Nuestro objetivo es describir cada trastorno metabólico asociado con su respectivo tipo de cálculo y su manejo

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Section: Calculi Formation Mechanismmentioning

confidence: 99%

Metabolic studies and calculi analysis in urinary lithiasis, how to stop recurrence?

Barco‐Castillo¹,

Uribe²,

Bohórquez³

et al. 2023

RUC

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“…The current literature suggests that low-intensity extracorporeal shockwave therapy appears to be effective in reducing penile pain, and at best, has a potential beneficial effect on disease stabilization but does not lead to significant improvement in plaque size and penile curvature [1,12]. Nonetheless, these outcomes should be interpreted with some caution due to underlying methodological flaws and perhaps inappropriate use of shockwave energy flow density [24,25]. Subgroup analysis of patients in the low-intensity extracorporeal shockwave therapy group showed overall better outcomes in younger patients with a relatively mild degree of curvature [26].…”

Section: Mechanical Therapy (Grade B Level 3)mentioning

confidence: 99%

A clinical pathway for the management of Peyronie’s disease: integrating clinical guidelines from the International Society of Sexual Medicine, American Urological Association and European Urological Association

Chung

Gillman

Tuckey³

et al. 2020

BJU International

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Objective To provide a clinical framework and key guideline statements to assist clinicians in the evidence‐based management of Peyronie’s disease (PD). Methods We conducted a review of the published literature relevant to PD management, with an emphasis on published clinical guidelines. References used in the text have been assessed according to their level of evidence, and guideline recommendations have been graded based on the Oxford Centre for Evidence‐based Medicine Levels of Evidence. Results The management of PD involves taking a detailed penile and sexual history, with a focused penile examination to identify plaque and hourglass deformity, and digital photographs of the erect curved (deformed) penis. Penile colour Duplex ultrasonography evaluates tunical plaque and underlying cavernosal smooth muscle and blood flow variables. The current therapy for PD can be divided into two main groups, namely, medical therapy and penile reconstructive surgery, and the patient should be counselled on the benefits and risks of each treatment option. Conclusions Peyronie’s disease remains a clinical challenge and presents a considerable therapeutic dilemma as the current therapy addresses existing penile curvature only and is not very effective in preventing future penile fibrosis and/or reversing underlying erectile dysfunction.

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“… 4 5 Mechanical stimulation of cells by the waves induces a cavitation effect with the generation of nitric oxide and vascular endothelial growth factor with subsequent neovascularization. 6 7 ESWT has shown promising results in penile rehabilitation after radical prostatectomy and vasculogenic erectile dysfunction and converted phosphodiesterase-5 inhibitor (PDE5i) nonresponders to responders. ESWT also had a neuroprotective effect and led to functional recovery in animal models.…”

Section: Introductionmentioning

confidence: 99%

Low-intensity extracorporeal shock wave therapy for Peyronie's disease

Abdessater

Akakpo²,

Kanbar³

et al. 2022

Asian Journal of Andrology

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The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy (LiESWT) protocol for the treatment of Peyronie's disease (PD). Patients treated for PD were prospectively recorded, and data were retrospectively reviewed. Age, characteristics of fibrous plaques, concomitant treatments, International Index of Erectile Function (IIEF-5), Lue score, and pain score on Likert scale were collected. Patients in acute phase of PD and an angulation of <40° were included. The protocol consisted of 6 weekly sessions of 4000 pulses each, applied from different directions, with a maximal power of 20 W and 8 Hz frequency. We included 39 patients (median age: 56.8 years, interquartile range [IQR]: 35.8–62.2 years). The median number of sessions received per patient was 7.2. After treatment, the median Lue score decreased from 6.8 initially to 3.3 ( P = 0.003), the median Likert pain score dropped from 1.8 to 0.7 ( P = 0.004), the median plaque size was reduced from 2 cm to 1.2 cm ( P = 0.08), and the median penile curvature diminished from 31° to 17° ( P = 0.07). On univariate and multivariate analysis, the only predictors of success were younger age (odds ratio [OR] = 0.95, P = 0.03 and OR = 0.91, P = 0.04, respectively) and concomitant use of phosphodiesterase-5 inhibitors (PDE5i; OR = 0.92, P = 0.02 and OR = 0.93, P = 0.01, respectively). LiESWT had a favorable impact on Lue score and notably penile pain, curvature, plaque size, and erectile function in patients treated for PD during the early inflammatory phase, with no side effects. Younger age and concomitant use of PDE5i were the only success predictors.

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Pro: does shockwave therapy have a place in the treatment of Peyronie’s disease?

Cited by 5 publications

References 24 publications

Metabolic studies and calculi analysis in urinary lithiasis, how to stop recurrence?

Metabolic studies and calculi analysis in urinary lithiasis, how to stop recurrence?

A clinical pathway for the management of Peyronie’s disease: integrating clinical guidelines from the International Society of Sexual Medicine, American Urological Association and European Urological Association

Low-intensity extracorporeal shock wave therapy for Peyronie's disease

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