Pro-dopamine regulator, KB220Z, attenuates hoarding and shopping behavior in a female, diagnosed with SUD and ADHD

Abstract

BackgroundAddictive-like behaviors (e.g., hoarding and shopping) may be the result of the cumulative effects of dopaminergic and other neurotransmitter genetic variants as well as elevated stress levels. We, therefore, propose that dopamine homeostasis may be the preferred goal in combating such challenging and unwanted behaviors, when simple dopaminergic activation through potent agonists may not provide any resolution.Case presentationC.J. is a 38-year-old, single, female, living with her mother. She has a history of substance use disorder as well as attention deficit hyperactivity disorder, inattentive type. She had been stable on buprenorphine/naloxone combination and amphetamine, dextroamphetamine mixed salts for many years when unexpectedly she lost her job for oversleeping and not calling into work. KB200z (a pro-dopamine compound) was added to her regimen for complaints of low drive and motivation. After taking this nutraceutical for 4 weeks, she noticed a marked improvement in her mental status and many behaviors. She noted that her shopping and hoarding addictions had appreciably decreased. Furthermore, her lifelong history of terrifying lucid dreams was eliminated. Finally, she felt more in control; her locus of control shifted from external to more internal.DiscussionThe hypothesis is that C.J.’s reported, behavioral, and psychological benefits resulted from the pro-dopamine-regulating effect of KB220Z across the brain reward system.ConclusionsThis effect, we surmise, could be the result of a new dopamine balance, across C.J.’s brain reward system. Dopamine homeostasis is an effect of KB220Z seen in both animal and human placebo-controlled fMRI experiments.

Associations between problematic Internet use and psychiatric symptoms among university students in Japan

“…Many studies have shown a relation between PIU and ADHD . Regardless of PIU, many reports indicate that ADHD is related to behavior dependence, such as substance‐related dependence and gambling dependence . Behavioral features of ADHD symptoms are said to be lack of self‐control, and it is fair to consider that such symptoms can lead to PIU.…”

“…[53][54][55] Regardless of PIU, many reports indicate that ADHD is related to behavior dependence, such as substance-related dependence and gambling dependence. [56][57][58] Behavioral features of ADHD symptoms are said to be lack of selfcontrol, 31,55 and it is fair to consider that such symptoms can lead to PIU. However, based on these observational studies, it is hard to understand the causal relationship of PIU and the aforementioned psychiatric symptoms.…”

Neurobiology and Genetics of Behavioral Addictions: A Brief Review

“…Addiction-like behaviors such as hoarding or compulsive buying may be associated with high stress levels and the cumulative effects of neurotransmitters genetic variants, particularly DA. Therefore, when outcomes of dopaminergic activation are unsatisfaying with agonist therapy, DA homeostasis can be targetted in treating these undesirable behaviors (113). Some reports suggest that hyperdopaminergic states are observed in impulsive hoarding behavior, such as…”

“…Several different cognitive domains were shown to support a possible neurobiological overlap between other behavioral and substance addictions to shopping addiction. Compared to healthy controls, individuals with compulsive buying appear to have deterioration in spatial working memory, response inhibition and risk assessment during decision-making (120).In a case report with substance use disorder, the addition of a pro-dopamine compound KB200z to the treatment regimen significantly reduced stacking and shopping behaviors (113).…”

Addiction by Any Other Name is Still Addiction: Embracing Molecular Neurogenetic/Epigenetic Basis of Reward Deficiency

“…These findings are supported through transcriptome analysis (the volume of messenger RNA molecules). Addictive disease (drug and non-drug (process) [22], depression [23], anxiety disorder [24], attention-deficit/hyperactivity disorder (ADHD) [25] and post-traumatic stress disorder (PTSD) [26] are all phenotypical conditions. Because these conditions share candidate genes and the co-occurring expression of neuropsychiatric conditions affecting the midbrain, ventral striatum, the term Reward Deficiency Syndrome has been coined to describe their shared etiology and pathophysiology [27].…”