Pro-estrogenic and anti-inflammatory effects of Corchorus olitorius and Amaranthus hybridus leaves in DMBA-induced breast cancer

Dania, Omoremime E.; Dokunmu, Titilope M.; Adegboye, Bose E.; Adeyemi, Alaba O.; Chibuzor, Favour C.; Iweala, Emeka E.J.

doi:10.1016/j.phyplu.2024.100567

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…About 50-80% of female breast cancers have been established to be estrogen-dependent where estrogen binding to receptor has been reported to stimulate tumor cell proliferation (Cruceriu et al, 2020;Leong and Zhuang, 2011;Smolarz et al, 2022;Vogel, 2008). Thus, estrogen hormone dependence accounts for a major cause in the incidence of women breast cancer (Dania et al, 2024). Two subtypes estrogen receptors, ER-α and ER-β, exist and exhibit distinct cellular and tissue distribution patterns in many cells and tissues in human thereby control key physiological functions (Farzaneh and Zarghi, 2016).…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

In-silico Study of Novel Dimeric flavonoid (OC251FR2) from the Seeds of Garcinia kola Heckel (Clusiaceae) Against Alpha Estrogen Receptor (ER-α) of Breast cancer

Eugene-Osoikhia,

Odozi,

Yeye

et al. 2024

Preprint

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In silico approach was used to investigate the inhibitory activities of a novel dimeric flavanonol OC251FR2 (3,3'-oxybis(5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one)-3,3'-oxybis(5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) isolated from the chloroform fraction of Garcinia kola, against alpha Estrogen receptor (ER-α); a major contributor to the growth of breast cancer. The docking was conducted using Maestro module 13.5 to obtained the ER-α PDB (5W9C) from NCBI. The OC251FR2 was docked using ligprep module with 4-hydroxytamoxifen being the reference drug. The qikpro was used to investigate the drug-likeliness while ligand docking and induced fit docking were used to investigate the interaction and binding affinity of the ligands with the active sites of the PDB. The result shows that the isolated OC251FR2 interact more with amino acids in the active sites via H-bond, pi-pi interaction than the reference drug 4-Hydroxytamoxifen. The drug-likeliness determined by qikpro shows that OC251FR2 violated three of the Lipinski rules of 5, and also have percent oral absorption. The quantum mechanics values show that OC251FR2 have similar properties comparable to the reference drug 4-hydroxytamoxifen. Hence, can serve as potential lead against alpha Estrogen receptor (ER-α).

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