Pro-inflammatory and (Epi-)genetic markers in saliva for disease risk in childhood obesity

Bizjak, Daniel Alexander; Ammerpohl, Ole; Schulz, Sebastian; Wendt, Janine; Steinacker, Jürgen M.; Flechtner-Mors, Marion

doi:10.1016/j.numecd.2022.03.016

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…In certain studies, the patients were instructed to rinse with water to eliminate any food debris and swallow the remaining saliva prior to the sampling [ 33 – 35 ]. Patients were asked to remain silent, to sit upright on the edge of their chair, keep their mouths open, and tilt their head slightly downward so that saliva could passively drain from the oral cavity and lower lip into a sterile collection device [ 36 ]. This position is also known as the “Coachman’s position” [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Saliva Collection Methods Among Children and Adolescents: A Scoping Review

Fey,

Bikker,

Hesse

2023

Mol Diagn Ther

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Objective Saliva can be used for screening and diagnostic purposes. Although multiple saliva collection methods are available, their use in children can be limited due to lack of cooperation, developmental stage, and age. The aim of this scoping review was to comprehensively appraise the different methods of saliva collection among both children and adolescents by assessing the available scientific literature. Methods A literature search was performed using the databases PubMed, Embase, and Web of Science. Eligible studies on saliva collection methods among children and adolescents were included for this review. Results The literature search identified 249 eligible articles, of which 205 had a cross-sectional study design. Four distinct saliva collection methods have surfaced: the drooling method, the absorption method, the spitting method, and the suction method. Among infants or children under the age of 6 years, the suction and absorption methods were most preferred. The drooling and spitting methods were only applicable among children above the age of 3 years. When children were not willing to cooperate, the absorption method was most feasible. In adolescents and older children, no specific method was found to be preferred over another method. Conclusion Overall, saliva collection is well tolerated by children and adolescents, with the absorption and suction methods being preferred with young and uncooperative children. Supplementary Information The online version contains supplementary material available at 10.1007/s40291-023-00684-9.

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