Pro–inflammatory cytokines profiles in Nigerian pregnant women infected with Plasmodium falciparum malaria

Nmorsi, O. P. G.; Isaac, César; Ohaneme, B. A.; Obiazi, H. A. K.

doi:10.1016/s1995-7645(10)60175-7

Cited by 12 publications

(24 citation statements)

References 17 publications

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“…Findings in this study of which IFN-γ, TNF-α, IL-6, IL-4 and IL-10 were significantly elevated in malaria infected pregnant than their uninfected pregnant counterparts is consistent with the findings of Szoba et al (2003) and Nmorsi et al (2010) respectively who reported that IFNγ and IL-6 were significantly elevated in malaria infected pregnant than the uninfected non-pregnant women. Also, our finding corroborates that of Torre et al (2002) who also reported significantly elevated levels of IFNγ, TNFα and IL-10 in malaria infected pregnant women than their control counterparts.…”

Section: Resultssupporting

confidence: 92%

Peripheral Parasitaemia and Its Association With Plasma Cytokines Levels in Malaria-Infected Pregnant Women in Aba, Abia State, Nigeria

Ifeanyichukwu

Okamgba

Amilo

et al. 2017

AJID

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Background: Cytokines in pregnant female may not be a normal phenomenon as malarial infection is often associated with strong CD4+ cell activation and up-regulation of pro-inflammatory cytokines. We investigated the relationship between peripheral parasitaemia and plasma levels of cytokines among malaria infected pregnant women in Aba, Abia State, Nigeria. Materials and Methods: A total of 206 non-HIV positive asymptomatic malaria parasitaemic (n=144) and non-parasitaemic (n=62) pregnant women were recruited for this study alongside 80 non-pregnant women who served as positive (n=40) and negative (n=40) controls. Blood samples were aseptically collected from each subject and tested for HIV and malaria parasites using standard methods. Also, plasma levels of cytokines were measured using Th1/Th2 human cytokine ELISA kits (Abcam, UK). Analysis of Variance and Student's t-test were used for Comparison of groups while Pearson's Correlation Coefficient was used for tests of association. Results:The results revealed a mean parasite density of 685.56±484.55 parasites/µl of blood. Malaria infected pregnant subjects showed significantly higher levels of IFN-γ, TNF-α, IL-4, IL-6 and IL-10 when compared with their non-infected counterparts (P< 0.05). The cytokines evaluated were higher in moderate parasitaemia than mild parasitaemia. Positive correlation existed between peripheral parasite density (PPD) and IL-4 (r= 0.24, P=0.004), PPD and IL-6 (r = 0.35, P = 0.001) as well as PPD and IL-10 (r = 0.29, P = 0.001). Conclusion:This study showed that increase in peripheral parasitaemia increased levels of some plasma cytokines (IL-4, IL-6 and IL-10) but not IFN-γ and TNF-α in the malaria infected pregnant women studied.

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Section: Resultssupporting

confidence: 92%

Peripheral Parasitaemia and Its Association With Plasma Cytokines Levels in Malaria-Infected Pregnant Women in Aba, Abia State, Nigeria

Ifeanyichukwu

Okamgba

Amilo

et al. 2017

AJID

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“…This was more marked in the primipara. These observations corroborate previous findings in Africa where high plasma levels of IL-10 were associated with malaria infection during pregnancy (Kabyemela et al, 2008;Nmorsi et al, 2010;Boström et al, 2012;Chandrasiri Upeksha et al, 2013;Chêne et al, 2014). High IL-10 levels have also been reported in mice models during pregnancy malaria (Megnekou et al, 2013).…”

Section: Discussionsupporting

confidence: 91%

Role of some biomarkers in placental malaria in women living in Yaoundé, Cameroon

Megnekou¹,

Djontu²,

Bigoga³

et al. 2015

Acta Tropica

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“…Proteins extracted from pyrimethanine-sensitive (T9/94) pI3 pI10 25 protein spots showed at least two-fold difference in density, some of which exhibited as high as ten-fold difference (Table 1). …”

Section: Resultsmentioning

confidence: 99%

“…In addition, contamination by human host proteins with a wide range of molecular weights and isoelectric points (pI) remains problematic for improvement of proteomic profiles. Modification of the extraction protocol based on types of samples, or utilization of a variety of chaotropic mixtures with detergents, has been applied to solve these problems [12][13][14][15][16][17][18][19][20][21][22][23][24][25] . Results from a previous study indicated that approximately 52 % of the proteins identified from P. falciparum blood stage samples were host red cell proteins [26] .…”

Section: Discussionmentioning

confidence: 99%

“…Marked reduction in density of protein expression was observed with the extract from the mutant (resistant) clone compared with the parent (sensitive) clone. A total of 25 protein spots showed at least two-fold difference in density, some of which exhibited as high as ten-fold difference. Conclusions: These proteins may be the molecular targets of resistance of Plasmodium falciparum to pyrimethamine.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of protein patterns between Plasmodium falciparum mutant clone T9/94-M1-1(b3) induced by pyrimethamine and the original parent clone T9/94

Rungsihirunrat

Chai่jaroenkul

Siripoon

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Pro–inflammatory cytokines profiles in Nigerian pregnant women infected with Plasmodium falciparum malaria

Cited by 12 publications

References 17 publications

Peripheral Parasitaemia and Its Association With Plasma Cytokines Levels in Malaria-Infected Pregnant Women in Aba, Abia State, Nigeria

Peripheral Parasitaemia and Its Association With Plasma Cytokines Levels in Malaria-Infected Pregnant Women in Aba, Abia State, Nigeria

Role of some biomarkers in placental malaria in women living in Yaoundé, Cameroon

Comparison of protein patterns between Plasmodium falciparum mutant clone T9/94-M1-1(b3) induced by pyrimethamine and the original parent clone T9/94

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