Pro-inflammatory effect of obesity on rats with burn wounds

Abstract

Objective A burn is an inflammatory injury to the skin or other tissue due to contact with thermal, radioactive, electric, or chemical agents. Burn injury is an important cause of disability and death worldwide. Obesity is a significant public health problem, often causing underlying systemic inflammation. Studying the combined impact of burn injuries on obese patients has become critical to the successful treatment of these patients. The aim of this paper is to highlight the effect of inflammation associated with burn injuries on several body weight group in a rat study. Materials and methods Different degrees of obesity and burns were established in rats and divided into a normal weight group, overweight group, obese group, second-degree burn group, third-degree burn group, over-weight second-degree burn group, over-weight third-degree burn group, obese second-degree burn group, and obese third-degree burn group (20 rats per group). Changes in inflammatory factors and growth factor were measured on the 1st, 3rd, 7th and 14th days after burns were inflicted. Results The ELISA test showed that in the unburned control group, MCP-1, IL-1β and TNF-α protein expressions in the obese and over-weight groups were higher than the normal-weight group (P < 0.05). RT-PCR test showed that the expressions of MCP-1, IL-1β and TNF-α genes in the obese group were higher compared to the overweight and normal weight groups (P < 0.05). Three and 7 days after burns were inflicted, the level of VEGF in the normal weight group was higher than the obese group (P < 0.05), however increased VEGF was not observed on days 1 and 14. Conclusion Burn injury and obesity have a mutually synergistic effect on the body’s inflammatory response.

Tolerance to Glucose and Lipid High Metabolic Reactions After Burns in an Obese Rat Model

“…Our study found that the expression of inflammatory factors in the obese groups with burn injuries was higher than the burn groups with normal weight, which was consistent with a previous study by our team. 28 We observed a tendency of first fast then slow of skin wound healing after burns were inflicted. There were no animal mortalities during the study period.…”

Preferential Mobilization of Colonic Hepatic Flexure Facilitates Pancreaticoduodenectomy Procedures

“…Elevated C-reactive protein, interleukin-10, adiponectin, and leptin are found in obese patients after surgery. 20 However, there is little research focusing on the effect of overweight and obesity on the surgical procedure itself.…”

“…Furthermore, obesity is considered to be associated with stronger systemic inflammation, inducing worse postoperative outcomes. Elevated C-reactive protein, interleukin-10, adiponectin, and leptin are found in obese patients after surgery 20. However, there is little research focusing on the effect of overweight and obesity on the surgical procedure itself.…”