Pro‐inflammatory effects after platelet transfusion: a review

Chen, Binzhen; Xiao, Rong

doi:10.1111/vox.12879

Cited by 18 publications

(17 citation statements)

References 74 publications

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“…When a global ROS reporter was used, cold storage was identified as a process that increases ROS generation, 20,22 while there was no increase in the level of superoxide species, 49 possibly due to SOD2 expressed by human PLT mitochondria 50 . Our study confirms the observation that long‐term cold storage results in dysmetabolic mitochondrial activity and ROS production, which may associate with increased inflammatory activation in vivo 51 …”

Section: Discussionsupporting

confidence: 81%

Antioxidant prevents clearance of hemostatically competent platelets after long‐term cold storage

et al. 2020

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Background Cold storage of platelets (PLTs) has the potential advantage of prolonging storage time while reducing posttransfusion infection given the decreased likelihood of bacterial outgrowth during storage and possibly beneficial effects in treating bleeding patients. However, cold storage reduces PLT survival through the induction of complex storage lesions, which are more accentuated when storage is prolonged. Study Design and Methods Whole blood–derived PLT‐rich plasma concentrates from seven PLT pools (n = 5 donors per pool). PLT additive solution was added (67%/33% plasma) and the product was split into 50‐mL bags. Split units were stored in the presence or absence of 1 mM of N‐acetylcysteine (NAC) under agitation for up to 14 days at room temperature or in the cold and were analyzed for PLT activation, fibrinogen‐dependent spreading, microparticle formation, mitochondrial respiratory activity, reactive oxygen species (ROS) generation, as well as in vivo survival and bleeding time correction in immunodeficient mice. Results Cold storage of PLTs for 7 days or longer induces significant PLT activation, cytoskeletal damage, impaired fibrinogen spreading, enhances mitochondrial metabolic decoupling and ROS generation, and increases macrophage‐dependent phagocytosis and macrophage‐independent clearance. Addition of NAC prevents PLT clearance and allows a correction of the prolonged bleeding time in thrombocytopenic, aspirin‐treated, immunodeficient mice. Conclusions Long‐term cold storage induces mitochondrial uncoupling and increased proton leak and ROS generation. The resulting ROS is a crucial contributor to the increased macrophage‐dependent and ‐independent clearance of functional PLTs and can be prevented by the antioxidant NAC in a magnesium‐containing additive solution.

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Section: Discussionsupporting

confidence: 81%

Antioxidant prevents clearance of hemostatically competent platelets after long‐term cold storage

et al. 2020

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“… 97 – 99 Furthermore, platelet transfusion might increase the proinflammatory response as well as the risk of VTE and PE in COVID-19. 99 , 100 Therefore, platelet transfusion should be considered carefully in COVID-19 patients.…”

Section: What Are the Knowledge Gaps?mentioning

confidence: 99%

COVID-19–Associated Coagulopathy and Inflammatory Response: What Do We Know Already and What Are the Knowledge Gaps?

Görlinger

Dirkmann

Gandhi³

et al. 2020

Anesthesia &Amp; Analgesia

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Patients with COVID-19 frequently experience a coagulopathy associated with a high incidence of thrombotic events leading to poor outcomes. Here, biomarkers of coagulation (such as D-dimer, fibrinogen, platelet count), inflammation (such as interleukin-6) and immunity (such as lymphocyte count) as well as clinical scoring systems (such as SOFA, ISTH DIC and SIC score) can be helpful in predicting clinical course, need for hospital resources (such as ICU beds, intubation and ventilator therapy, and ECMO) and patient’s outcome in patients with COVID-19. However, therapeutic options are actually limited to unspecific supportive therapy. Whether viscoelastic testing can provide additional value in predicting clinical course, need for hospital resources and patient’s outcome or in guiding anticoagulation in COVID-19 associated coagulopathy is still incompletely understood and currently under investigation (eg, in the ROHOCO study). This paper summarizes what we know already about COVID-19 associated coagulopathy and – perhaps even more importantly – characterizes important knowledge gaps.

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“…The detected plasma protein levels of the rats indicated that none of the rat administered with PPMO showed the plasma osmotic pressure alteration in sub-chronic toxicity study. PLT is a component of blood that reacts to bleeding from blood vessel injury by clumping, thereby initiating a blood clot 32) . The detected PLT levels suggested that the rat administrated with PPMO did not alter the blood coagulation function in sub-chronic toxicity study.…”

Section: Discussionmentioning

confidence: 99%

<i>In vivo</i> Toxicity Assessment of Refined Red Palm-pressed Mesocarp Olein in Sprague-Dawley Rats

et al. 2021

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Pro‐inflammatory effects after platelet transfusion: a review

Cited by 18 publications

References 74 publications

Antioxidant prevents clearance of hemostatically competent platelets after long‐term cold storage

Antioxidant prevents clearance of hemostatically competent platelets after long‐term cold storage

COVID-19–Associated Coagulopathy and Inflammatory Response: What Do We Know Already and What Are the Knowledge Gaps?

<i>In vivo</i> Toxicity Assessment of Refined Red Palm-pressed Mesocarp Olein in Sprague-Dawley Rats

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