Pro-inflammatory effects induced by bradykinin in a murine model of pleurisy

Prostaglandin Receptors EP2, EP3, and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy

“…The involvement of the kinin system in the earlier phase in concert with PGs is also confirmed in the mouse model of carrageenin-induced pleurisy. Furthermore, this study demonstrates that the experimental mouse pleurisy is a useful tool for evaluation of common mediators for inflammatory exudation, as was previously shown in the rat and rabbit models (Peck et al, 1978;Oh-ishi et al, 1986;Ogino et al, 1996;Saleh et al, 1997).…”

Analysis of the mechanisms involved in the inflammatory response induced by des-Arg9-bradykinin in the rat pleural cavity

“…2 C and 2 D). The treatment of animals with the kinin selective B 2 HOE140 (3 nmol/cavity, 30 min) or with B 1 des-Arg 9 -[Leu 8 ]-BK and R715 receptor antagonists, at the same range of doses where they significantly inhibited kinininduced pleurisy in mice [14,15] or prevented the cardiovascular response to des-Arg 9 -BK in rats [16], failed to affect the increase in the total cell influx elicited by des-Arg 9 -BK in rats (Fig. 3 A, 3 B and 3 C).…”

“…The doses of drugs used in this study were chosen according to data appearing in literature [14,15,16,17] and also in agreement with the preliminary experiments (results not shown).…”

Anti-inflammatory evaluation of Coronopus didymus in the pleurisy and paw oedema models in mice

“…The pleurisy experiments were carried out as previously described (Saleh et al, 1997;Da Cunha et al, 2001;Pereira et al, 2006) and different phlogistic agents were used (Carrageenan: Cg, braykinin: BK, histamine: HIS, substance P: SP and prostaglandin E 2 : PGE 2 ). The animals were killed with an overdose of pentobarbital, the thorax was opened, and the pleural cavity was washed with 1.0 mL of sterile phosphate buffered saline (PBS, pH 7.6, composition mmol: NaCl 137, KCl 2.7 and phosphate buffer salts 10) containing heparin (20 IU/mL).…”