Pro-lymphangiogenic properties of IFN-γ-activated human dendritic cells

Gagliostro, Vincenzo; Seeger, Pascal; Garrafa, Emirena; Salvi, Valentina; Bresciani, Roberto; Bosisio, Daniela; Sozzani, Silvano

doi:10.1016/j.imlet.2016.03.008

Cited by 16 publications

(8 citation statements)

References 66 publications

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“…39 IFN-g also activates DCs and induces biologically active VEGF-C production resulting in inflammation-associated lymphangiogenesis. 40 However, we and others showed that LECs express receptors not only for growth factors such as VEGFs but also for inflammatory cytokines. 1,20 Moreover, they directly respond to these growth factors and cytokines during development and inflammation.…”

Section: Discussionmentioning

confidence: 89%

Interleukin-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

Shin

et al. 2018

Mucosal Immunology

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During inflammation lymphatic vessels (LVs) are enlarged and their density is increased to facilitate the migration of activated immune cells and antigens. However, after antigen clearance, the expanded LVs shrink to maintain homeostasis. Here we show that interleukin (IL)-17A, secreted from T helper type 17 (T17) cells, is a negative regulator of lymphangiogenesis during the resolution phase of T17-mediated immune responses. Moreover, IL-17A suppresses the expression of major lymphatic markers in lymphatic endothelial cells and decreases in vitro LV formation. To investigate the role of IL-17A in vivo, we utilized a cholera toxin-mediated inflammation model and identified inflammation and resolution phases based on the numbers of recruited immune cells. IL-17A, markedly produced by T17 cells even after the peak of inflammation, was found to participate in the negative regulation of LV formation. Moreover, blockade of IL-17A resulted in not only increased density of LVs in tissues but also their enhanced function. Taken together, these findings improve the current understanding of the relationship between LVs and inflammatory cytokines in pathologic conditions.

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Section: Discussionmentioning

confidence: 89%

Interleukin-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

Shin

et al. 2018

Mucosal Immunology

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“…Activated NK cells can in return stimulate DC maturation through the secretion of TNFa and IFNg that increase the ability of DCs to produce cytokines and to prime Th1 and cytotoxic T lymphocyte (CTL) responses (43,71,72). In melanoma patients, NK cells regulate cDC1 survival and infiltration through the intratumoral production of FLT3LG; this action correlates with the efficacy of the therapeutic response to anti-PD1 immunotherapy (47).…”

Section: Nk Cell and DC Crosstalk In Cancermentioning

confidence: 99%

NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment

et al. 2021

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NK cells are innate lymphoid cells endowed with cytotoxic capacity that play key roles in the immune surveillance of tumors. Increasing evidence indicates that NK cell anti-tumor response is shaped by bidirectional interactions with myeloid cell subsets such as dendritic cells (DCs) and macrophages. DC-NK cell crosstalk in the tumor microenvironment (TME) strongly impacts on the overall NK cell anti-tumor response as DCs can affect NK cell survival and optimal activation while, in turn, NK cells can stimulate DCs survival, maturation and tumor infiltration through the release of soluble factors. Similarly, macrophages can either shape NK cell differentiation and function by expressing activating receptor ligands and/or cytokines, or they can contribute to the establishment of an immune-suppressive microenvironment through the expression and secretion of molecules that ultimately lead to NK cell inhibition. Consequently, the exploitation of NK cell interaction with DCs or macrophages in the tumor context may result in an improvement of efficacy of immunotherapeutic approaches.

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“…The accumulation of pDCs in ovarian cancer epithelium is an independent prognostic factor associated with early relapse [161]. PDCs can also induce lymphangiogenesis and neo-angiogenesis through the production of VEGF-C [162], TNF-α and IL-8 which are hallmarks of poor prognosis associated with multifocal intra-peritoneal dissemination [110]. In cutaneous melanoma, the presence of pDCs in draining lymph nodes is associated with poor prognosis [106].…”

Section: Prognostic Value Of DC Subsets In Tmementioning

confidence: 99%

Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications

Prete

Sozio

Barbazza

et al. 2020

IJMS

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Dendritic cells (DCs) constitute a complex network of cell subsets with common functions but also with many divergent aspects. All dendritic cell subsets share the ability to prime T cell response and to undergo a complex trafficking program related to their stage of maturation and function. For these reasons, dendritic cells are implicated in a large variety of both protective and detrimental immune responses, including a crucial role in promoting anti-tumor responses. Although cDC1s are the most potent subset in tumor antigen cross-presentation, they are not sufficient to induce full-strength anti-tumor cytotoxic T cell response and need close interaction and cooperativity with the other dendritic cell subsets, namely cDC2s and pDCs. This review will take into consideration different aspects of DC biology, including the functional role of dendritic cell subsets in both fostering and suppressing tumor growth, the mechanisms underlying their recruitment into the tumor microenvironment, as well as the prognostic value and the potentiality of dendritic cell therapeutic targeting. Understanding the specificity of dendritic cell subsets will allow to gain insights on role of these cells in pathological conditions and to design new selective promising therapeutic approaches.

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Pro-lymphangiogenic properties of IFN-γ-activated human dendritic cells

Cited by 16 publications

References 66 publications

Interleukin-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

Interleukin-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment

Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications

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