Pro-oxidant and antioxidant responses in the liver and kidney of wild Goodea gracilis and their relation with halomethanes bioactivation

Olivares-Rubio, Hugo F.; Martínez-Torres, M. Lysset; Domínguez-López, María Lilia; Garcı́a-Latorre, Ethel; Vega-López, Armando

doi:10.1007/s10695-013-9812-8

Cited by 13 publications

(10 citation statements)

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“…Results indicate that the order of DNA‐damaging potency is: BDCM > DBCM > bromoform > chloroform. Metabolism by cytochrome P450 seems to proceed mainly through the CYP2E1 isoform, resulting in the production of reactive intermediates and reactive oxygen species (ROS) (Porubsky et al, ) in laboratory rodents (Seth et al, ) and fish (Vega‐Lopez et al, ; Olivares‐Rubio et al, ). Oxidative stress induces significant cellular injury at various levels, including lipid peroxidation and oxidative DNA damage.…”

Section: Introductionmentioning

confidence: 99%

Trihalomethanes in liver pathology: Mitochondrial dysfunction and oxidative stress in the mouse

Faustino-Rocha

Rodrigues

Costa

et al. 2015

Environmental Toxicology

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Trihalomethanes (THMs) are disinfection byproducts found in chlorinated water, and are associated with several different kinds of cancer in human populations and experimental animal models. Metabolism of THMs proceeds through enzymes such as GSTT1 and CYP2E1 and gives rise to reactive intermediates, which form the basis for their toxic activities. The aim of this study was to assess the mitochondrial dysfunction caused by THMs at low levels, and the resulting hepatic histological and biochemical changes in the mouse. Male ICR mice were administered with two THMs: dibromochloromethane (DBCM) and bromodichloromethane (BDCM); once daily, by gavage, to a total of four administrations. Animals were sacrificed four weeks after DBCM and BDCM administrations. Blood biochemistry was per-formed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), albumin (Alb), total protein (TP), creatinine, and urea. Animals exposed to DBCM and BDCM showed elevated ALT and TB levels (p < 0.05) as compared with controls. Histological analysis confirmed the presence of vacuolar degenerescence and a multifocal necrotizing hepatitis in 33% of animals (n 5 2). Mitochondrial analysis showed that THMs reduced mitochondrial bioenergetic activity (succinate dehydrogenase (SQR), cytochrome c 2 oxidase (COX), and ATP synthase) and increased oxidative stress (glutathione S-transferase (GST)) in hepatic tissues (p < 0.05). These results add detail to the current understanding of the mechanisms underlying THM-induced toxicity, supporting the role of mitochondrial dysfunction and oxidative stress in liver toxicity caused by DBCM and BDCM.

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Section: Introductionmentioning

confidence: 99%

Trihalomethanes in liver pathology: Mitochondrial dysfunction and oxidative stress in the mouse

Faustino-Rocha

Rodrigues

Costa

et al. 2015

Environmental Toxicology

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“…In contrast, in specimens of dusky splitfin exposed to CHCl 3 levels of RC=O were above controls (p<0.05 and p<0.01; Figure 3E). In some water bodies, the renal content of RC=O in G. gracilis was below controls (Olivares-Rubio et al, 2013), as it was also observed in fishes exposed to CH (Thomas et al, 1990) o por reacciones radicalarias es factible la formación de polímeros con baja actividad biológica (Gregus, 2008 • is a defense mechanism in the innate immunity. Similar results were found in the liver of G. gracilis exposed in the same conditions in this study (Dzul-Caamal et al, 2013).…”

Section: Oxidative Damage (Rooh Sratb and Rc=o)mentioning

confidence: 78%

“…Juveniles of indistinct sex aged eight months (50.40±0.65 mm and 0.94±0.06 g) in non-reproductive state born in the lab were used for the tests. orgánica y precursores de HM (Vega-López et al, 2012;Olivares-Rubio et al, 2013). En el hígado y el riñón de G. gracilis "habitante de tres lagos del centro de México" se encontró que la presencia de HM fue capaz de inhibir la respuesta metabólica de estos peces , lo que sugiere la generación de metabolitos reactivos (Parkinson y Ogilvie, 2008) particularmente los derivados de la GST isoforma tetha.…”

Section: Species Under Study and Experimental Proceduresunclassified

“…Para las autoridades mexicanas las especies vulnerables y en peligro de extinción son prioritarias para su estudio (Olivares-Rubio et al, 2013). El tiro oscuro Goodea gracilis (Hubbs y Turner, 1939) es una especie vulnerable (IUCN Red List Status Ref.…”

Section: Introductionunclassified

“…matrotrophy (Doadrio and Domıńguez, 2004). In some cases, it inhabits environments fed by treatment plants of residual waters that contain organic matter and precursors of HM (Vega-Lopez et al, 2012;Olivares-Rubio et al, 2013). In liver and kidney of G. gracilis, inhabitant of three lakes from central Mexico, it was found that the presence of HM was able to inhibit the metabolic response of these fishes (Olivares-Rubio et al, 2013), which suggests the generation of reactive metabolites (Parkinson and Ogilvie, 2008), particularly those derived from the GST tetha isophorm.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress, CYP 2E1, GSTT, halomethanes. antioxidant defense (superoxide dismutase, catalase and glutathione peroxidase), as also occurred with total glutathione S-transferase, while the others HM elicited an irregular response. These findings suggest that toxic effects elicited by HM on the kidney of fish are complex and more studies are needed to expand knowledge on the subject. Revista Bio Ciencias 4(4), Article ID 04.04.04 Mayo 2017 Cite this paper/Como citar este artículo: Olivares-Rubio, H.F; Vega López, A. (2017). Pro-oxidant and antioxidant response in the kidney of an endemic mexican fish (Goodea gracilis) exposed to CH 2 Cl 2 , CHCl 3 and BrCHCl 2. Revista Bio Ciencias 4(4), 20 pages, Article ID: 04.04.01.

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Relationship between biomarkers and endocrine-disrupting compounds in wild Girardnichthys viviparus from two lakes with different degrees of pollution

Olivares-Rubio¹,

Dzul-Caamal²,

Gallegos-Rangel³

et al. 2015

Ecotoxicology

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Despite great efforts worldwide to evaluate the effects of endocrine-disrupting compounds (EDCs) in fish, there is little information available about the interactions of EDCs with the disruption of the sexual endocrine axis in fish species with matrotrophic viviparity and intraluminal gestation. To understand these interactions, six sampling campaigns were performed within a period of 1 year in two lakes with different degrees of pollution. A battery of biomarkers of the oestrogenic response was assessed in the liver [vitellogenin, CYP 1A1, epoxide hydrolase activity, and metallothioneins (MT)] and MT in the head of Girardinichthys viviparus. Linear correlation analysis and canonical correspondence analysis were performed to explore the relationship between the oestrogenic response with EDCs and with metals. The biomarker responses were assessed using the water content of EDCs (oestrone, 17-β-oestradiol, oestriol, 17-α-ethinyl oestradiol, total phenols, bisphenol A, nonyl phenol, octyl phenol), as well as the PAHs indene[1,2,3-c,d]pyrene, naphthalene, pyrene, benzo[a]anthracene, benzo[k]fluoranthene and benzo[a]pyrene) and metals (Cu, Fe, Mn, Pb and Zn). Greater disruption of the sexual endocrine axis occurred in fish of both sexes inhabiting the polluted lake whose effects were apparently influenced by CYP 1A1 activity and by 17-α-ethinyl oestradiol. In addition, non-estrogenic mechanisms in the hypothalamus and pituitary glands in male fish were observed, elicited by endogenous levels and the water concentration of Pb. In contrast, in females from the less polluted lake, VTG induction was related to exogenous oestrogens. The disruption of the hypothalamic-pituitary-gonadal axis is a complex process influenced by both endogenous and exogenous factors and contributes to male feminisation by exposure to EDCs.

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Pro-oxidant and antioxidant responses in the liver and kidney of wild Goodea gracilis and their relation with halomethanes bioactivation

Cited by 13 publications

References 41 publications

Trihalomethanes in liver pathology: Mitochondrial dysfunction and oxidative stress in the mouse

Trihalomethanes in liver pathology: Mitochondrial dysfunction and oxidative stress in the mouse

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Relationship between biomarkers and endocrine-disrupting compounds in wild Girardnichthys viviparus from two lakes with different degrees of pollution

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