Pro-Oxidantive Effect of Dehydroepiandrosterone on Indomethacin-Induced Acute Gastritis in Rats

Kim, Beom-Gyu; Yim, Sung-Hyuk; Jeong, Seong-Jin; Choi, Youn Joo; Nam, Yunsung; Jeong, Ja A; Yun, Sin-Weon; Do, Jae-Hyuk; Lim, Hyun-Muck; Park, Eon-Sub

doi:10.4062/biomolther.2009.17.1.57

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Previous studies reported that DHEA had antioxidant effects in various acute and chronic oxidative stress experiments (Jacob et al, ; Savineau, Marthan, & Dumas, ; Schwartz & Pashko, ). While, the effects of DHEA administration can be antioxidant (Jacob et al, ) or pro‐oxidant (Kim et al, ; Mastrocola et al, ) depending on the administered dose and specific tissue (Pélissier et al, ). Gallo et al () and Mastrocola et al () reported that slightly higher concentrations of DHEA protected cells against lipid peroxidation induced by oxidative stress, while at pharmacological doses, DHEA displayed a pro‐oxidant activity.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of liver disease increases with age and older individuals are more susceptible to most acquired liver disorders (Huang, Hu, & Bao, ), and which may be related to the imbalance of oxidative homeostasis. Previous studies reported that DHEA exhibited antioxidant (Jacob, Janner, Bellóklein, Llesuy, & Ribeiro, ; Jacob et al, ) or pro‐oxidant effects (Kim et al, ; Mastrocola et al, ), and the modulatory functions depending on the dose administered and specific tissue (Gallo et al, ; Pélissier, Muller, Hill, & Morfin, ). Gallo et al () reported that slightly higher concentrations of DHEA protected cells against lipid peroxidation induced by oxidative stress, while DHEA displayed a pro‐oxidant activity at pharmacological doses.…”

Section: Introductionmentioning

confidence: 99%

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Dehydroepiandrosterone rehabilitate BRL‐3A cells oxidative stress damage induced by hydrogen peroxide

Zhao

et al. 2018

Journal Cellular Physiology

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This study aimed to investigate the molecular mechanism of dehydroepiandrosterone (DHEA) rehabilitated BRL-3A cells oxidative stress damage induced by hydrogen peroxide (H O ). Results showed that DHEA reversed the decrease of cell viability and ameliorated nuclear chromatin damage in H O -induced BRL-3A cells. DHEA increased the activities of superoxide dismutase, catalase, peroxidase, and glutathione peroxidase, and decreased the reactive oxygen species (ROS) production in H O -induced BRL-3A cells. DHEA attenuated the protein damage and lipid peroxidation, and reduced the apoptosis in H O -induced BRL-3A cells. The mRNA levels of Bax, Caspase-9, and Caspase-3 were decreased, while the Bcl-2 mRNA level was increased in H O -induced BRL-3A cells treated with DHEA. Our results showed that DHEA treatment increased the PI3K and p-Akt protein levels, while decreased the Bax and capase-3 protein levels in H O -induced BRL-3A cells. However, the rise in PI3K and p-Akt protein levels, and the decrease in Bax and capase-3 protein levels induced by DHEA treatment were reversed when the cells pretreated with LY294002 (PI3K inhibitor). These results indicated that DHEA ameliorated H O -induced oxidative damage by increasing anti-oxidative enzyme activities and ameliorating the protein damage and lipid peroxidation in BRL-3A cells. In addition, DHEA decreased the apoptosis by inhibiting caspase-3 and Bax protein levels and this action mainly achieved via the activation of PI3K/Akt signaling pathways in H O -induced BRL-3A cells. These results provided substantial information for DHEA as a nutritional supplement to treat oxidative stress and it related diseases in animals and humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone rehabilitate BRL‐3A cells oxidative stress damage induced by hydrogen peroxide

Zhao

et al. 2018

Journal Cellular Physiology

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“…It plays a critical endogenous antioxidant and pro-oxidant activity. It can also protect against cell membrane lipid peroxidation (LPO) induced by oxidative damage 6 . DHEA also has anti-inflammatory properties via suppression of pro-inflammatory cytokines secretion like IL and TNF-α and regulating the body's immune response 7 .…”

Section: Introductionmentioning

confidence: 99%

The Influential Antioxidant Role Of Coenzyme Q10 and Dehydroepiandrosterone against Carbon Tetrachloride Induced Liver Damage In Male Rats

Al-Rekabi¹,

Hussein²,

Al-Shwilly³

et al. 2023

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This study evaluated the protective role of exogenous CoQ10 and DHEA and their combination on CCl4-induced hepatotoxicity in adult male rats. Thirty adult male rats 225-250 grams, 12-14 weeks old, were used in this study and randomly divided into five equal groups, 6 animals each as in the following: Control group (G1): 6 male rats received DMSO 0.5ml/ animal/day orally, First treated group (T1): 6 male rats received daily CCl4 1ml/kg (1:1 olive oil, IP), Second treated group (T2): 6 male rats received CCl4 1ml/ kg and after 1hour injected daily with CoQ10 200 mg/kg IP, Third treated group (T3): 6 male rats received CCl4 1ml/kg and after 1hour injected daily with DHEA 25 mg/kg IP, Fourth treated group (T4): 6 male rats received CCl4 1ml/kg and after 1hour injected daily with a combination of CoQ10 200 mg/kg + DHEA 25 mg/kg IP. The experiment lasted for 28 successive days. The obtained results illustrated that male rats received CCl4 (1ml/kg) caused a significant increase in hepatic enzyme function AST, ALT and ALP, as well as MDA levels, and caused a significant decrease in antioxidant enzyme activity GPx, SOD and CAT levels. In addition, CCl4 also caused various degrees of liver damage, such as dilation and congestion of the central vein with hemorrhage, apparent fatty degeneration and infiltration of inflammatory cells compared to the control group. Whereas, the group treated with CoQ10 200 mg/kg and DHEA 25 mg/kg showed a significant decrease (P< 0.05) in serum AST, ALT and ALP as well as MDA value, and significantly increased in GPx, SOD with the decline in CAT levels compared to the group treated with CCl4 intoxication. It is also observed from the results that the combination of CoQ10 and DHEA caused a highly significant (P < 0.05) decline in AST, ALT and ALP as well as MDA levels, and a significant elevate in GPx, SOD and decline in CAT, and almost return to average level compared to control. As well as, the histopathological examination of the liver revealed that rats treated with CoQ10 and DHEA and their combination had usual central veins and hepatocytes compared to groups treated with CCl4 due to antioxidant, anti-inflammatory and anti-apoptotic properties. It has been concluded that CoQ10 and DHEA have a protective effect against liver damage induced by CCl4 through improving antioxidant enzyme activity in CCl4 treated group leading to a declined MDA level and reduced lipid peroxidation. Thus, CoQ10 and DHEA are potential therapeutic antioxidant agents on hepatotoxicity by suppressing hepatic oxidative stress. Keywords: CoQ10, DHEA, antioxidant, CCl4, hepatic damage, male rat.

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Olive ( Olea europaea ) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities

Al‐Quraishy

Othman

Dkhil

et al. 2017

Biomedicine & Pharmacotherapy

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Pro-Oxidantive Effect of Dehydroepiandrosterone on Indomethacin-Induced Acute Gastritis in Rats

Cited by 3 publications

References 27 publications

Dehydroepiandrosterone rehabilitate BRL‐3A cells oxidative stress damage induced by hydrogen peroxide

Dehydroepiandrosterone rehabilitate BRL‐3A cells oxidative stress damage induced by hydrogen peroxide

The Influential Antioxidant Role Of Coenzyme Q10 and Dehydroepiandrosterone against Carbon Tetrachloride Induced Liver Damage In Male Rats

Olive ( Olea europaea ) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities

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