(Pro)renin Receptor and LDL Clearance

Strong, Alanna; Musunuru, Kiran

doi:10.1161/circresaha.115.308068

Cited by 5 publications

(1 citation statement)

References 20 publications

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“…Speculatively, we may propose one of them to be the difference in (pro)renin level or (pro)renin receptor activity, which are both potent factors that influence different metabolic pathways including hepatic LDL-C turnover and, of course, its serum level. 42 – 45 Moreover, RAAS overactivity may lead to liver dysfunction promoting inflammation, lipodystrophy, liver steatosis and lipid metabolism disturbances. 46 – 48 Feltenberger et al demonstrated the reversibility of the aforementioned effects by an oral formulation of Ang (1–7) in mice.…”

Section: Discussionmentioning

confidence: 99%

The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension

Pizon

Rajzer

Wojciechowska

et al. 2018

J Renin Angiotensin Aldosterone Syst

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Introduction:The aim of the study was to evaluate clinical and biochemical differences between patients with low-renin and high-renin primary arterial hypertension (AH), mainly in reference to serum lipids, and to identify factors determining lipid concentrations.Materials and methods:In untreated patients with AH stage 1 we measured plasma renin activity (PRA) and subdivided the group into low-renin (PRA < 0.65 ng/mL/h) and high-renin (PRA ⩾ 0.65 ng/mL/h) AH. We compared office and 24-h ambulatory blood pressure, serum aldosterone, lipids and selected biochemical parameters between subgroups. Factors determining lipid concentration in both subgroups were assessed in regression analysis.Results:Patients with high-renin hypertension (N = 58) were characterized by higher heart rate (p = 0.04), lower serum sodium (p < 0.01) and aldosterone-to-renin ratio (p < 0.01), and significantly higher serum aldosterone (p = 0.03), albumin (p < 0.01), total protein (p < 0.01), total cholesterol (p = 0.01) and low-density lipoprotein cholesterol (LDL-C) (p = 0.04) than low-renin subjects (N = 39). In univariate linear regression, only PRA in the low-renin group was in a positive relationship with LDL-C (R2 = 0.15, β = 1.53 and p = 0.013); this association remained significant after adjustment for age, sex, and serum albumin and aldosterone concentrations.Conclusions:Higher serum levels of total and LDL-C characterized high-renin subjects, but the association between LDL-C level and PRA existed only in low-renin primary AH.

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Section: Discussionmentioning

confidence: 99%

The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension

Pizon

Rajzer

Wojciechowska

et al. 2018

J Renin Angiotensin Aldosterone Syst

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(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease

Gayban

Souza

Cooper

et al. 2022

Preprint

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Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism. Here, we hypothesized that inhibition of the PRR would prevent the development of diet-induced hepatic steatosis and fibrosis. To test our hypothesis, we fed wild-type mice on a C57Bl/6J background either a high-fat diet (HFD; 60% calories from fat) or normal fat diet (NFD; 10% calories from fat) with matching calories for 6 weeks. An 8-week methionine choline-deficient (MCD) diet was used to induce fibrosis in C57BL/6J mice. Two weeks following diet treatment, mice were implanted with a subcutaneous osmotic pump delivering either PRO20, a peptide PRR antagonist, or scrambled peptide (700 ug/kg/d) for 4 or 6 weeks. We found that a 6-week HFD significantly increased liver lipid accumulation, as detected by Oil Red O staining, and liver triglyceride content compared with NFD-fed mice. Importantly, PRO20 treatment significantly reduced hepatic lipid accumulation in HFD-fed mice without affecting body weight or glucose levels. Furthermore, PRR antagonism attenuated HFD-induced steatosis, particularly microvesicular steatosis. In the MCD diet model, the percentage of collagen area detected by Sirius Red staining was reduced in PRO20-treated compared with control mice. PRO20 treatment also significantly decreased levels of liver alanine aminotransferase (ALT), an indicator of liver damage, in MCD-fed mice compared with controls. Mechanistically, we found that PRR antagonism prevented HFD-induced increases in PPARγ and glycerol-3-phosphate acyltransferase 3 expression in the liver. Taken together, our findings establish the mechanism by which PRR regulates lipid metabolism in the liver and suggest the therapeutic potential of PRR antagonism for the treatment of liver steatosis and fibrosis development in NAFLD.

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Features of the Lipid Profile in Different Activity of the Components of the Renin-angiotenzin-aldosterone System in Patients with Essential Hypertention and Obesity

Kochuieva

Psarova

Кириченко

et al. 2019

FMEP

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Харківська медична академія післядипломної освіти 2 Сумський державний університет 3 Харківська державна академія фізичної культури 4 ДУ «Національний інститут терапії ім. Л.Т. малої НАмН України», м. Харків Мета дослідження: оцінювання особливостей ліпідного профілю при різній активності компонентів ренін-ангіотензин-альдостеронової системи у пацієнтів з артеріальною гіпертензією (АГ) і супутнім ожирінням. Матеріали та методи. Обстежено 188 пацієнтів з гіпертонічною хворобою (ГХ) і ожирінням І-ІІ ступенів, які дали інформовану письмову згоду на участь у дослідженні і відповідали критеріям включення. У контрольну групу увійшли 25 практично здорових осіб, співставних за віком і статтю з пацієнтами основної групи. Результати. У результаті проведеного дослідження встановлено, що у пацієнтів з коморбідністю ГХ і ожиріння І-ІІ ступенів низькоренінова АГ (НРАГ) встановлена у 9,4% випадків. НРАГ і високоренінова АГ (вРАГ) у пацієнтів з ожирінням не відрізнялися значеннями антропометричних показників. Заключення. За наявності НРАГ у пацієнтів з ожирінням І-ІІ ступенів, рівні атерогенних ліпопротеїдів були достовірно нижчими, ніж при вРАГ.

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(Pro)renin Receptor and LDL Clearance

Cited by 5 publications

References 20 publications

The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension

The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension

(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease

Features of the Lipid Profile in Different Activity of the Components of the Renin-angiotenzin-aldosterone System in Patients with Essential Hypertention and Obesity

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