2019
DOI: 10.3390/cells8020110
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Pro-Thrombotic Activity of Blood Platelets in Multiple Sclerosis

Abstract: The available data, including experimental studies, clearly indicate an excessive intravascular activation of circulating platelets in multiple sclerosis (MS) and their hyper-responsiveness to a variety of physiological activators. Platelet activation is manifested as an increased adhesion and aggregation and is accompanied by the formation of pro-thrombotic microparticles. Activated blood platelets also show an expression of specific membrane receptors, synthesis many of biomediators, and generation of reacti… Show more

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Cited by 36 publications
(33 citation statements)
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“…Currently, there is relatively little information about the functioning of blood platelets during neurodegeneration and knowledge about their participation in these diseases is still neglected and poorly understood. However, available clinical data have confirmed the elevated activation of circulating platelets in MS [48]. Our previous study revealed an increase in the prothrombotic and proinflammatory properties of platelets [11,49,50].…”
Section: Discussionmentioning
confidence: 74%
“…Currently, there is relatively little information about the functioning of blood platelets during neurodegeneration and knowledge about their participation in these diseases is still neglected and poorly understood. However, available clinical data have confirmed the elevated activation of circulating platelets in MS [48]. Our previous study revealed an increase in the prothrombotic and proinflammatory properties of platelets [11,49,50].…”
Section: Discussionmentioning
confidence: 74%
“…It has been shown that cytokines such as interleukin (IL)-1 and IL-6 may affect the change of mean platelet volume (MPV), which is regarded as a marker of platelet activation inflammation [58,59]. Studies also found that platelets can serve as key coordinators involved in several inflammatory processes [60,61] and in the occurrence and development of several inflammatory diseases including inflammatory bowel disease, solid cancers, psoriasis multiple sclerosis and bronchial asthma [62][63][64]. However, few studies and meta-analyses have demonstrated the association between PLR and AA.…”
Section: Potential Mechanismsmentioning
confidence: 99%
“…Nevertheless, besides this primary function, platelets are also recognized to affect immune and inflammatory responses, thus participating in regulation of biological mechanisms underlying a broad range of human disorders. A large body of experimental and clinical evidences, indeed, shows that platelet activation and dysfunction are implicated in diabetes, cardiovascular disease, chronic back pain, sepsis, Alzheimer's disease, multiple sclerosis, psychiatric disorders and other central and peripheral pathological conditions [7][8][9][10][11]. In this context, the unexpected central role of platelets in cancer biology is noteworthy: They actively influence cancer cell behavior, but, on the other hand, platelet physiology and phenotype are impacted by tumor cells [12].…”
Section: Introductionmentioning
confidence: 99%