Proactive and Progressive Approaches in Managing Obesity

Eckel, Robert H.; Bays, Harold; Klein, Samuel; Horn, Deborah B.

doi:10.1080/00325481.2016.1181412

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…To date, the mechanism of how and why an imbalance occurs has not been fully understood. The regulation of energy homeostasis is complex and involves multiple factors, such as neural and endocrine systems related to food intake, environments linked to food availability, and sedentary lifestyles associated with energy expenditure [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Meng

Groth

2018

Journal of Nutrition and Metabolism

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Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG). The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG. An observational study was conducted with 85 African American pregnant women. Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy. Seven obesity-risk genetic variants were genotyped. Regression analyses with bootstrapping methods were used to examine the moderation and mediation effects of dietary intake. The mean GWG was 14.2 kg, and 55.3% of the women gained above the Institute of Medicine GWG guidelines. A nominally significant association was found between rs17782313 (close to MC4R) and percentage of energy intake from fat (P=0.043). A variant downstream of KCTD15 (rs11084753) was nominally significantly related to GWG (P=0.023). There was a significant interaction between the KCTD15 polymorphism and dietary fat intake (P=0.048). Women with the AG genotype gained more weight during pregnancy with more dietary fat consumption. In conclusion, our results indicate that dietary macronutrients, especially fat intake, may modify the effect of the KCTD15 gene on GWG. Improved knowledge of gene-diet interactions can facilitate the development of personalized interventions.

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Section: Introductionmentioning

confidence: 99%

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Meng

Groth

2018

Journal of Nutrition and Metabolism

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“…According to a Finnish study that have shown that those who succeed with weight maintenance are less sedentary, are more physically active (one hour per day), consume less alcohol and smoked less [5]. Addressing these issues requires behaviour and lifestyle modifications and the provision of individualised therapy [6].…”

Section: Introductionmentioning

confidence: 99%

Two-year weight, risk and health factor outcomes of a weight-reduction intervention programme: Primary prevention for overweight in a multicentre primary healthcare setting

Bräutigam-Ewe

Lydell

Bergh

et al. 2020

Scandinavian Journal of Primary Health Care

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Objective: To study the long-term effects of weight reduction, quality of life and sense of coherence in a primary health care (PHC)-based programme with two different intensities. Design: Prospective two-armed randomised intervention. Setting: Three PHC centres in south west of Sweden. Subjects: In total, 289 women and men aged 40-65 years with a BMI of 28-35 were recruited for a two-year weight-reduction programme. Participants were randomized to high-intensity or lowintensity groups. Blood samples, physical measurements and questionnaires were analysed. Participants received cookbooks and dietary lectures. The high-intensity group also received Motivational interviewing (MI), dietary advice on prescription (DAP-advice), a grocery store lecture, a website and weekly e-mails. Main outcome measures: Weight, quality of life, risks and health factors. Results: In total, 182 (64%) participants completed the 2-year follow-up. The total sample reduced their weight by 1 kg (p ¼ 0.006). No significant differences regarding weight were found between the groups. Anxiety/depression decreased in EQ5-D (p ¼ 0.021), EQ5-D VAS (p ¼ 0.002) and SOC (p ¼ 0.042). Between the groups, there were significant differences in EQ5-D usual activities (p ¼ 0.004), anxiety/depression (p ¼ 0.013), pain/discomfort (p ¼ 0.041), fruit and vegetables (p ¼ 0.005), HLV anxiety (p ¼ 0.005), and visits to nurses (p ¼ 0.012). Conclusion: The total population lost weight, and the high-intensity and low-intensity programmes did not result in significant differences in terms of weight. The high-intensity programme reported health benefits linked to lower levels of anxiety and depression, increased activity and intake of greens and reduced visits to physicians and nurses. KEY POINTS Both groups had a consisting weight-reduction after two years. High intensity did not lead to a significant difference in weight reduction between the groups. The high-intensity group reported more health effects, such as better quality of life, reduced anxiety, and increased greenery intake. It is unknown how much support patients in a weight-reduction programme in PHC require to succeed with weight loss and a healthy lifestyle ARTICLE HISTORY

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Recognizing Obesity as a Disease

Christensen

2021

A Clinician’s Guide to Discussing Obesity With Patients

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Proactive and Progressive Approaches in Managing Obesity

Cited by 6 publications

References 40 publications

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Two-year weight, risk and health factor outcomes of a weight-reduction intervention programme: Primary prevention for overweight in a multicentre primary healthcare setting

Recognizing Obesity as a Disease

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