Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI

Ahonen, Merja; Kahru, Anne; Ivask, Angela; Kasemets, Kaja; Kõljalg, Siiri; Mantecca, Paride; Vrček, Ivana Vinković; Keinänen‐Toivola, Minna M.; Crijns, F. R. L.

doi:10.3390/ijerph14040366

Cited by 61 publications

(62 citation statements)

References 94 publications

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“…An in-depth analysis of the toxicity and persistence of nanoantimicrobials in the environment is necessary to assess the safety of AMCs within the context of SbD. The rationale behind adding an antimicrobial agent to a specific surface should be balance between the potential impact of the antimicrobial agent on the emergence of resistant microbial strains and the impact of preventing the spread of the pathogenic microbial strains within the healthcare environment, and thus on the control of HCAI [88]. Several strategies have been employed to produce SbD reduced toxicity antimicrobial nanomaterials [89,90].…”

Section: Importance Of Safe-by-design In Antimicrobial Coatingsmentioning

confidence: 99%

Surface modifications for antimicrobial effects in the healthcare setting: a critical overview

Adlhart

Verran

Azevedo

et al. 2018

Journal of Hospital Infection

258

218

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The spread of infections in healthcare environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (e.g. implants, catheters), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc., or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. This review addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated with the implementation of such anticontamination measures. Different chemistry-based approaches are discussed, for instance anti-adhesive surfaces (e.g. superhydrophobic, zwitterions), contact-killing surfaces (e.g. polymer brushes, phages), and biocide-releasing surfaces (e.g. triggered release, quorum sensing-based systems). The review also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (e.g. toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability) when developing and implementing antimicrobial surfaces.

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Section: Importance Of Safe-by-design In Antimicrobial Coatingsmentioning

confidence: 99%

Surface modifications for antimicrobial effects in the healthcare setting: a critical overview

Adlhart

Verran

Azevedo

et al. 2018

Journal of Hospital Infection

258

218

View full text Add to dashboard Cite

show abstract

“…4 The development of antimicrobial (polymeric) coatings is a potential and promising weapon against the growth and spread of microorganisms. 4,6 The demand is increased for the biocidal polymeric coating materials due to their capability of killing microbes upon contact. 4 Various chemical strategies and technologies for AMCs are described in the literature: (1) AMCs containing active eluting agents (e.g., ions, nanoparticles [silver, copper, zinc, etc.…”

Section: Introductionmentioning

confidence: 99%

“…], or antibiotics); (2) contact active immobilized molecules (e.g., quaternary ammonium/chitosan polymers or peptides); or (3) light-activated molecules (e.g., TiO 2 or photosensitizers). 4,6 The demand is increased for the biocidal polymeric coating materials due to their capability of killing microbes upon contact. 1,5,[7][8][9] The attention is paid on the synthesis of antimicrobial reactive polymers/coatings due to their low toxicity, long-term activity, increased antimicrobial activity, high effectiveness and selectivity, stability, and also due to eco-friendly performance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and fabrication of high‐potent antimicrobial polymeric ultrathin coatings

Nagaraja

Puttaiahgowda

Devadiga

2019

J of Applied Polymer Sci

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The development of antimicrobial coatings in various sectors is escalating nowadays. However, design, synthesis, and fabrication of simple antimicrobial polymer coatings with potent biocidal action against pathogenic microbes are necessary to emerge. The current article deals with fabrication of high efficient ultrathin coatings of synthesized polymer for controlling pathogenic bacteria and fungi. The article is intensified with simple synthesis, characterization, fabrication of ultrathin coatings and their antimicrobial studies. The polymer structure is elucidated by FTIR, 1 HNMR, and 13 CNMR, and the thermal properties are explained by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). The antimicrobial activity of a polymer and their ultrathin coatings against Escherichia coli, Staphylococcus aureus, tubercular-variant Mycobacterium smegmatis, and Candida albicans are reported elaborately. The morphology of ultrathin coating and their interaction with microorganisms are studied using a scanning electron microscope and an atomic force microscope.

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“…potential emergence of microbial resistance or emission of toxic agents into the environment); standardized performance assessments for AMCs; and identification and dissemination of best practices by hospitals, other clinical facilities, regulators and manufacturers. Using a consultation process that previously elicited the opinions of expert stakeholders regarding safe use of AMCs [16], views were collated regarding specialized cleaning associated with AMCs for reduction of HCAIs. Particular emphasis was placed on awareness of new cleaning approaches that may impact the effectiveness of AMCs, the generation of effluent or wastewater that may contain coating-derived antimicrobial agents, and the consequent potential for generation of antimicrobial resistance.…”

Section: Introductionmentioning

confidence: 99%

Specialized cleaning associated with antimicrobial coatings for reduction of hospital-acquired infection: opinion of the COST Action Network AMiCI (CA15114)

Dunne

Ahonen

Modić

et al. 2018

Journal of Hospital Infection

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Recognized issues with poor hand hygiene compliance among healthcare workers and reports of recontamination of previously chemically disinfected surfaces through hand contact emphasize the need for novel hygiene methods in addition to those currently available. One such approach involves antimicrobial (nano) coatings (AMCs), whereby integrated active ingredients are responsible for elimination of micro-organisms that come into contact with treated surfaces. While widely studied under laboratory conditions with promising results, studies under real-life healthcare conditions are scarce. The views of 75 contributors from 30 European countries were collated regarding specialized cleaning associated with AMCs for reduction of healthcare-associated infection. There was unanimous agreement that generation of scientific guidelines for cleaning of AMCs, using traditional or new processes, is needed. Specific topics included: understanding mechanisms of action of cleaning materials and their physical interactions with conventional coatings and AMCs; that assessments mimic the life cycle of coatings to determine the impact of repetitive cleaning and other aspects of ageing (e.g. exposure to sunlight); determining concentrations of AMC-derived biocides in effluents; and development of effective de-activation and sterilization treatments for cleaning effluents. Further, the consensus opinion was that, prior to widespread implementation of AMCs, there is a need for clarification of the varying responsibilities of involved clinical, healthcare management, cleaning services and environmental safety stakeholders.

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Proactive Approach for Safe Use of Antimicrobial Coatings in Healthcare Settings: Opinion of the COST Action Network AMiCI

Cited by 61 publications

References 94 publications

Surface modifications for antimicrobial effects in the healthcare setting: a critical overview

Surface modifications for antimicrobial effects in the healthcare setting: a critical overview

Synthesis and fabrication of high‐potent antimicrobial polymeric ultrathin coatings

Specialized cleaning associated with antimicrobial coatings for reduction of hospital-acquired infection: opinion of the COST Action Network AMiCI (CA15114)

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