Proactive Cancer Prevention and Treatment: An Interview with Charles B. Simone, M.M.S., M.D.

Lieberman, Shari

doi:10.1089/107628003321537002

Cited by 1 publication

(3 citation statements)

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“…Prior work has shown that vitamin C can produce cytotoxic levels of hydrogen peroxide at sufficient concentrations. As previously mentioned, tumor cells have leaky membranes that allow vitamin C to flood into cells 7 and cancer cells are generally catalase-and superoxide-dismutase-deficient, making them more sensitive to the killing effect of hydrogen peroxide. 11 Vitamin C has enhanced the antitumor activity of doxorubicin, cisplatin, and paclitaxel in human breast-cancer cells in culture.…”

Section: Cytotoxicity Of Vitamin Cmentioning

confidence: 99%

“…Studies using high dose oral vitamin C along with other antioxidants adjuvantly with chemotherapy and radiation have shown decreased toxicity and increased tumor response, improved quality of life, and improved survival time. 2,[7][8][9][10][11]13 Intravenous Vitamin C as a Chemotherapeutic Agent…”

Section: Cytotoxicity Of Vitamin Cmentioning

confidence: 99%

“…Cancer cells, however, have leaky membranes, allowing large amounts of antioxidants to flood into cells at doses that are lethal to cancers. 7,10,11 Cancer cells, in particular, are susceptible to high-dose ascorbate-induced peroxidation products (such as hydrogen peroxide) because of these cells' deficiencies in the antioxidant enzymes catalase and superoxide dismutase. Vitamin C accumulates in solid tumors at levels higher than those in surrounding normal tissue.…”

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confidence: 99%

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Intravenous Vitamin C Therapy: A Natural Agent for Treating Cancer

Lieberman

2005

Alternative and Complementary Therapies

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ccording to the American Cancer Society, cancer rates continue to rise each year. 1 It has been estimated that the incidence of new cancers in the United States may be as high as 1.2 million cases per year. In addition, 600,000 deaths each year result from cancer. 2 Despite breakthroughs often announced by the media, there is presently no effective strategy to reduce the risk of recurrence of a primary tumor or the development of a second cancer induced by conventional treatment. Conventional cancer therapy (radiation, chemotherapy, and surgery) has made very few breakthroughs in cancer treatment. These small breakthroughs include producing increased cure rates for specific tumors in Hodgkin's disease, teratocarcinoma, and childhood leukemia. Unfortunately, there are no major breakthroughs in the more common cancers, such as breast, prostate, lung, and colon. Despite the strides that have been made, there is still risk of recurrence and development of new cancers and nonneoplastic disease-such as aplastic anemia; retardation of growth in children; and delayed necrosis in some organs such as brain, liver, bone, and muscle-without any good standard options for their prevention in conventional oncology. Serious side-effects and the potential for the damage of normal healthy tissues and organs is a continuing problem with chemotherapy and radiation therapy. Organ and tissue damage and other serious adverse effects often cause patients to disrupt and/or discontinue therapy. 2 The question of whether or not to use antioxidants with chemotherapy and radiation therapy continues to be a cause of debate among most oncologists. Yet, they freely prescribe synthetic antioxidants, such as dexrazoxane and amifostine, to minimize chemotherapy and radiation side-effects. More than 30 years of human and animal research demonstrate that antioxidants reduce toxicity and increase tumor killing when given with chemotherapy and radiation. Several studies have demonstrated that antioxidants enhance the growth inhibitory effect of chemotherapy and radiation, suggesting that mechanisms other than free-radical generation are responsible for the tumor-killing effects of these treatments. 2-9

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Section: Cytotoxicity Of Vitamin Cmentioning

confidence: 99%