Proangiogenic peptide nanofiber hydrogel/3D printed scaffold for dermal regeneration

Cui, Bin; He, Jinmei; Wang, Zhen; Liu, Lan-lan; Li, Xiaoli; Wu, Chaoxi; Chen, Changsheng; Tu, Mei

doi:10.1016/j.cej.2020.128146

Cited by 37 publications

(48 citation statements)

References 38 publications

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“…Also, it is possible to observe in Table 1 that six articles used a full‐thickness skin wound at the back of the animals 21,23–28 as an injury model and only one performed a full‐thickness skin burn 22 . Different wound sizes were used, ranging from 7.5 mm 2 in diameter to 45 mm 2 24,26 and different timepoints were analyzed with a minimum experimental period of 3 days and maximum experimental period of 30 days 23,24 . Most of the studies implanted the 3D printed wound constructs immediately after the induction of the wound 21,23–27,29 .…”

Section: Resultsmentioning

confidence: 99%

“…For the ink composition, different biomaterials were used by the different authors. Michael et al 28 used a commercial matrix, Kim et al 27 and Jin et al 25 used a decellularized porcine skin, Chu et al 23 used gelatin, Roshangar et al 22 used alginate as a matrix, and Ma et al 26 used gelatin and methacrylic anhydride. In addition, Wang et al 21 also used alginate as matrix for ink associated to PLGA and Azamadesh et al 29 used PLA hyaluronic acid, copper carbon dots, rosmarinic acid, and chitosan.…”

Section: Resultsmentioning

confidence: 99%

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3D printed wound constructs for skin tissue engineering: A systematic review in experimental animal models

et al. 2023

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Wound dressings are one of the most used treatments for chronic wounds. Moreover, 3D printing has been emerging as a promising strategy for printing 3D printed wound constructs, being able of manufacturing multi layers, with a solid 3D structure. Although all these promising effects of 3D printed wound constructs, there is still few studies and limited understanding of the interaction of these dressings with skin tissue and their effect on the process of skin wound healing. In this context, the aim of this work was to perform a systematic review of the literature to examine the effects of 3D printed wound constructs on the process of skin wound healing in animal models. The articles were selected from three databases following Medical Subject Headings (MeSH) descriptors “3D printing,” “skin,” “wound,” and “in vivo.” After the selection, exclusion and inclusion criteria, nine articles were analyzed. This review confirms the significant benefits of using 3D printed wound constructs for skin repair and regeneration. All the used inks demonstrated the ability of mimicking the structure of skin tissue and promoting cell adhesion, proliferation, migration, and mobility. Furthermore, in vivo findings showed full wound closure in most of the studies, with well‐organized dermal and epidermal layers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

3D printed wound constructs for skin tissue engineering: A systematic review in experimental animal models

et al. 2023

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“…In a new strategy for skin bioprinting, pro-angiogenic peptides were incorporated in hydrogel patches for the fabrication of 3D-bioprinted skin constructs. These improved bio-inks exhibited excellent printability and vascularization properties and provided beneficial roles in skin wound healing [ 231 , 232 ]. In a recent study, an angiogenic 3D-bioprinted peptide patch was developed for the improvement of skin wound healing.…”

Section: Innovative Strategies For Wound Healingmentioning

confidence: 99%

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Kolimi

Narala

Nyavanandi

et al. 2022

Cells

179

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Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and chronic state which is more susceptible to infections. Chronic wounds affect patients’ quality of life along with increased morbidity and mortality and are huge financial burden to healthcare systems worldwide, and thus requires specialized biomedical intensive treatment for its management. The clinical assessment and management of chronic wounds remains challenging despite the development of various therapeutic regimens owing to its painstakingly long-term treatment requirement and complex wound healing mechanism. Various conventional approaches such as cell therapy, gene therapy, growth factor delivery, wound dressings, and skin grafts etc., are being utilized for promoting wound healing in different types of wounds. However, all these abovementioned therapies are not satisfactory for all wound types, therefore, there is an urgent demand for the development of competitive therapies. Therefore, there is a pertinent requirement to develop newer and innovative treatment modalities for multipart therapeutic regimens for chronic wounds. Recent developments in advanced wound care technology includes nanotherapeutics, stem cells therapy, bioengineered skin grafts, and 3D bioprinting-based strategies for improving therapeutic outcomes with a focus on skin regeneration with minimal side effects. The main objective of this review is to provide an updated overview of progress in therapeutic options in chronic wounds healing and management over the years using next generation innovative approaches. Herein, we have discussed the skin function and anatomy, wounds and wound healing processes, followed by conventional treatment modalities for wound healing and skin regeneration. Furthermore, various emerging and innovative strategies for promoting quality wound healing such as nanotherapeutics, stem cells therapy, 3D bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based approaches, and cold plasma treatment therapy have been discussed with their benefits and shortcomings. Finally, challenges of these innovative strategies are reviewed with a note on future prospects.

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“…In a recent study, a proangiogenic peptide hydrogel/3D printed scaffold was created by Chu et al 21 They integrated the GEETEVTVEGLEPG (Ten-2) and a β-sheet structural peptide to synthesize SLg hydrogel, which was combined with GelMA in the subsequent manufacturing process. 3D printed scaffold possessed excellent properties such as controlled porosity, pore size, and connected pores.…”

Section: Fabrication Approaches For Prevascularized Skinmentioning

confidence: 99%

Strategies for vascularized skin modelsin vitro

et al. 2022

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Proangiogenic peptide nanofiber hydrogel/3D printed scaffold for dermal regeneration

Cited by 37 publications

References 38 publications

3D printed wound constructs for skin tissue engineering: A systematic review in experimental animal models

3D printed wound constructs for skin tissue engineering: A systematic review in experimental animal models

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Strategies for vascularized skin modelsin vitro

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