Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Sun, Ya-Sai; Wang, Ziwei; Gao, Zhe; Zhao, Wen; Thakur, Kiran; Zhong, Qian; Wei, Zhao‐Jun

doi:10.1016/j.crfs.2022.05.009

Cited by 9 publications

(4 citation statements)

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“…While a direct comparison of these quantification based on dry weight are difficult with our own measurements on fresh weight, we can conclude that several wild berries harbor high PAC concentrations rivalling the levels in foods generally seen as the best PAC dietary sources ( Gu et al, 2004 ; Rue et al, 2018 ). PAC extracted from hawthorn berries have been studied for anticancer properties ( Sun et al, 2022 ), though it should be noted that dense PAC polymers are unlikely to have bioactive properties.…”

Section: Resultsmentioning

confidence: 99%

Polyphenolic profiles of a variety of wild berries from the Pacific Northwest region of North America

Higbee

Brownmiller

Solverson

et al. 2023

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Polyphenolic profiles of a variety of wild berries from the Pacific Northwest region of North America

Higbee

Brownmiller

Solverson

et al. 2023

Current Research in Food Science

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“…Additionally, Hawthorn oligomeric procyanidin extracts have demonstrated the ability to enhance apoptosis and exhibit an anticancer effect by modulating the expression levels of caspase-9 in the mitochondrial pathway, caspase-8 in the death receptor pathway, and caspase-3, serving as a common downstream regulator of both pathways. This discovery offers a fresh approach for treating colon cancer patients in clinical practice ( Sun et al, 2022 ). Hawthorn leaf extract showed the ability to enhance the apoptosis of cancer cells ( Omairi et al, 2020 ).…”

Section: Anticancer Effects and Underlying Mechanisms Of Hawthorn-der...mentioning

confidence: 99%

Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

Zhou,

Nan,

et al. 2024

Front. Pharmacol.

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Over the past few years, there has been a gradual increase in the incidence of cancer, affecting individuals at younger ages. With its refractory nature and substantial fatality rate, cancer presents a notable peril to human existence and wellbeing. Hawthorn, a medicinal food homology plant belonging to the Crataegus genus in the Rosaceae family, holds great value in various applications. Due to its long history of medicinal use, notable effects, and high safety profile, hawthorn has garnered considerable attention and plays a crucial role in cancer treatment. Through the integration of modern network pharmacology technology and traditional Chinese medicine (TCM), a range of anticancer active ingredients in hawthorn have been predicted, identified, and analyzed. Studies have shown that ingredients such as vitexin, isoorientin, ursolic acid, and maslinic acid, along with hawthorn extracts, can effectively modulate cancer-related signaling pathways and manifest anticancer properties via diverse mechanisms. This review employs network pharmacology to excavate the potential anticancer properties of hawthorn. By systematically integrating literature across databases such as PubMed and CNKI, the review explores the bioactive ingredients with anticancer effects, underlying mechanisms and pathways, the synergistic effects of drug combinations, advancements in novel drug delivery systems, and ongoing clinical trials concerning hawthorn’s anticancer properties. Furthermore, the review highlights the preventive health benefits of hawthorn in cancer prevention, offering valuable insights for clinical cancer treatment and the development of TCM with anticancer properties that can be used for both medicinal and edible purposes.

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“…Hawthorn B–type proanthocyanidin polymorphs composed of epicatechin strongly inhibited intracellular tyrosinase activity and melanogenesis and induced apoptosis in mouse melanoma cells (Liang et al., 2022). It blocked the HCT116 cell cycle in the G2/M phase through the p53‐cyclin B pathway and promoted apoptosis partly through the mitochondrial (cysteine 9‐cysteine 3) and death receptor (cysteine 8‐cysteine 3) pathways (Sun, Wang et al., 2022). Meanwhile, two new pairs of lignan enantiomers (1a/1b and 2a/2b) isolated from the whole hawthorn fruit were cytotoxic to Hep3B hepatoma cells with IC50 values of 34.97 ± 2.74 and 17.42 ± 0.71 μM, respectively.…”

Section: Bioactivities Based On In Vitro and In Vivo Studiesmentioning

confidence: 99%

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

Ma,

Yang,

et al. 2024

Food Frontiers

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The discovery of new natural sources has brought increased attention to the development of functional foods. The hawthorn (Crataegus pinnatifida Bge.) fruit is an underutilized fruit due to its benefits for human health and good taste. It contains a variety of bioactive ingredients, contributing to its multiple beneficial functions and applications. This review summarized and discussed the main bioactive ingredients, beneficial functions based on in vitro, in vivo, and human studies, and different applications of the hawthorn fruit according to the updated literature in the past 3 years. Hawthorn berries contain phenolic acids, flavonoids, proanthocyanidins, pectin, and many other bioactive components, which have a variety of beneficial functions, such as antioxidant, anti‐inflammatory, antibacterial, antidiabetic, intestinal protection, cardiovascular protection, hepatoprotection, anti‐cancer, and neuroprotection. Its potential molecular mechanism and different food‐related applications such as hawthorn wine and antioxidant drink are discussed in detail in this review. Additionally, hawthorn berries are shown to be safe when consumed within the proper dosage. Collectively, this updated review indicates that the hawthorn fruit can be a new dietary source of bioactive ingredients with multiple beneficial functions and can be affordably developed into functional and medicinal foods for the prevention and management of certain chronic diseases.

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Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Cited by 9 publications

References 50 publications

Polyphenolic profiles of a variety of wild berries from the Pacific Northwest region of North America

Polyphenolic profiles of a variety of wild berries from the Pacific Northwest region of North America

Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

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