Proapoptotic and anti-angiogenic activity of (2E)-3-(2-bromo-6-hydroxy-4-methoxyphenyl)-1-(naphthalene-2-yl) prop-2-en-1-one in MCF7 cell line

Guruswamy, Dileep Kumar M.; Jayarama, Shankar

doi:10.1007/s11696-020-01051-2

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…In another work Guruswamy and Jayarama (2020) [ 49 ] carried out synthesis of chalcone derivatives by the Claisen–Schmidt method. The resulting compound ( 26 ) ( Figure 7 ) demonstrated incredible anticancer potential in MCF7 cells, with IC50 estimates of 6.55–10.14 µM.…”

Section: Chalcones With Anticancer Activitymentioning

confidence: 99%

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies

et al. 2023

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Chalcones are direct precursors in the biosynthesis of flavonoids. They have an α,β-unsaturated carbonyl system which gives them broad biological properties. Among the biological properties exerted by chalcones, their ability to suppress tumors stands out, in addition to their low toxicity. In this perspective, the present work explores the role of natural and synthetic chalcones and their anticancer activity in vitro reported in the last four years from 2019 to 2023. Moreover, we carried out a partial least square (PLS) analysis of the biologic data reported for colon adenocarcinoma lineage HCT-116. Information was obtained from the Web of Science database. Our in silico analysis identified that the presence of polar radicals such as hydroxyl and methoxyl contributed to the anticancer activity of chalcones derivatives. We hope that the data presented in this work will help researchers to develop effective drugs to inhibit colon adenocarcinoma in future works.

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Section: Chalcones With Anticancer Activitymentioning

confidence: 99%

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies

et al. 2023

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“…Through the AO/EB (acridine orange and etidium bromide) double staining method, nuclear recoloring was executed [16]. HT-29 cells were collected from the control and d1 treated category.…”

Section: Acridine Orange/ethidium Bromide Stainingmentioning

confidence: 99%

“…As per the manufacturer's instruction, cDNA was synthesized from 2 µg of RNA utilizing a verso cDNA synthesis kit, accompanied by an oligo dT primer. The reaction volume was set to 20 µL and synthesis of cDNA was carried out for 1 h at 42 • C, followed by RT inactivation for 5 min at 85 • C. Samples of the resultant products were examined in 1.5% agarose gel [16].…”

Section: Rt-pcrmentioning

confidence: 99%

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Synthesis of 3-Trifluoromethyl-5,6-dihydro-[1,2,4]triazolo Pyrazine Derivatives and Their Anti-Cancer Studies

Raveesha

Kumar

Prasad

2020

Molbank

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The synthesis of a wide variety of 3-trifluoromethyl-5,6-dihydro-[1,2,4]triazolo pyrazine derivatives, by the treatment of 3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine hydrochloride with an array of isocyanates in the presence of triethylamine, is reported. All the target compounds were synthesized in excellent yields under mild reaction conditions. The target molecules were effectively screened for their anti-cancer properties and the results are promising. The resultant compounds were assessed for their antiproliferative action against two human colon cancer cell lines (HCT-116 and HT-29 colon cancer cell lines). The IC50 range was estimated at 6.587 to 11.10 µM showing that compound RB7 had remarkable anticancer movement on HT-29. Additionally, it was discovered that RB7 incited the mitochondrial apoptotic pathway by up-regulating Bax and down-regulating Bcl2, eventually leading to the activation of Caspase 3 in HT-29 cells and initiation of cell death via the mitochondrial apoptotic pathway.

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“…The, α β-unsaturated carbonyl framework empowers chalcones and is richly present in nature from greeneries to higher plants [24][25][26][27][28]. They consist of an aromatic compound with an unsaturated side chain and are effective drugs for both in-vitro as well as in-vivo animal models [29]. Through Claisen-Schmidt condensation the chalcones were synthesized which includes aldol condensation of suitable aldehyde and ketone by acid or base-catalyzed and followed by dehydration.…”

Section: Introductionmentioning

confidence: 99%

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model

Guruswamy¹,

Balaji²,

Dharmappa

et al. 2020

Oncotarget

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Proapoptotic and anti-angiogenic activity of (2E)-3-(2-bromo-6-hydroxy-4-methoxyphenyl)-1-(naphthalene-2-yl) prop-2-en-1-one in MCF7 cell line

Cited by 7 publications

References 27 publications

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies

Synthesis of 3-Trifluoromethyl-5,6-dihydro-[1,2,4]triazolo Pyrazine Derivatives and Their Anti-Cancer Studies

Novel 3-(3, 5-difluoro-4-hydroxyphenyl)-1-(naphthalen-2-yl) prop-2-en-1-one as a potent inhibitor of MAP-kinase in HeLa cell lines and anti-angiogenic activity is mediated by HIF-1α in EAC animal model

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