Proapoptotic and prepulse inhibition (PPI) disrupting effects of Hypericum perforatum in rats

Standardized extract of Ficus platyphylla reverses apomorphine-induced changes in prepulse inhibition and locomotor activity in rats

“…Classical and atypical antipsychotics that are clinically used have been shown to selectively inhibit CAR [16]. FP as well as clozapine effectively [41], Catha edulis [42], Glycyrrhiza glabra [43] or Clerodendrum inerme [44] are known to induce PPI deficits in rodents.…”

Trends in the Use of Driving-Impairing Medicines According to the DRUID Category: A Population-Based Registry Study with Reference to Driving in a Region of Spain between 2015 and 2019

“…In this sense, beneficial nutrients and antioxidants, including coenzyme Q10 (CoQ10) and alpha-tocopherol (α-Toc), and genistein proved to exhibit a neuroprotective effect attributed to its antioxidant, and/or anti-apoptotic properties [37,38] as well as α-Toc and/or CoQ10, where the underlying molecular mechanism of the treating compounds is related to the vascular endothelial growth factor (VEGF) and enhancing the brain-derived neurotrophic factor (BDNF)/tyrosine kinase B (TrkB)/cAMP-response element-binding protein (CREB) signaling pathway [39]. Additionally, the effects of the administration of the anti-amnestic dose of St. John's wort extract and hyperforin on the ability to manage one's cognitive disturbance in psychotic and Huntington's disease patients were studied, among which the manifestation of prepulse inhibition (PPI) deficit was detected [40], wherein hyperforin was found to be one of the active ingredients responsible for St. John's wort-induced PPI disruption with no relation to apoptotic processes [41].…”