Proarrhythmic risk and determinants of cardiac autonomic dysfunction in collagen-induced arthritis rats

Lin, Ting Tse; Sung, Yen-Ling; Wu, Chih En; Zhang, Hong; Liu, Yen‐Bin; Lin, Shien Fong

doi:10.1186/s12891-016-1347-6

Cited by 10 publications

(6 citation statements)

References 35 publications

(25 reference statements)

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“…The short-long-short sequences of ventricular conduction in atrial fibrillation may trigger ventricular arrhythmias [27]. Besides, AF may increase sympathetic tone and decrease parasympathetic tone because of their hemodynamic effects and favor VF development, especially in male patients [28,29].…”

Section: Discussionmentioning

confidence: 99%

Atrial fibrillation and the risk of sudden cardiac arrest in patients with hypertrophic cardiomyopathy - A nationwide cohort study

Liao

Juang

et al. 2021

EClinicalMedicine

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Background: Hypertrophic cardiomyopathy (HCM), affecting 0.2% of the population, is the leading cause of sudden cardiac arrest (SCA). Incident atrial fibrillation (AF) is associated with an increased risk of SCA in general population. To determine whether AF is associated with an increased risk of SCA in patients with HCM. Methods: This nationwide cohort study analyzed data from Registry for Catastrophic Illness, which encompassed almost 100% of the patients with HCM in Taiwan from 1996 to 2013. Follow-up and data analysis ended December 31, 2013. The main outcome was physician-adjudicated SCA, defined as death from a sudden, pulseless condition presumed due to a ventricular tachyarrhythmia. The secondary outcome was nonsudden cardiac death (NSCD), which was heart failure death, stroke death and non-HCM related death. We used Cox proportional hazards models to assess the association between AF and SCA/NSCD, adjusting for baseline demographic and cardiovascular risk factors. Findings: A total 10,910 subjects participated in this study with mean age of 62 years. Among enrolled subjects, 1,169 (10.7%) developed AF, which was independently associated with elder age, female sex, and history of heart failure (HF) hospitalization. During follow-up (median, 8.5 years and 2th to 7th interquartile range, 3.6 to 16.5 years), 371 SCA (166 in AF and 205 in non-AF group) and 797 NSCD (417 in AF and 380 in non-AF group) events occurred. The crude incidence rates of SCA were 12.45/1000 person-years (with AF) and 3.57/1000 person-years (without AF). The crude incidence rates for NSCD were 31.29/1000 person-years (with AF) and 6.63/1000 person-years (without AF). The multivariable hazard ratios (HRs) (95% CI) of AF for SCA and NSCD were 3.633 (2.756À4.791) and 2.086 (1.799À2.418), respectively. Furthermore, among the etiologies of NSCD, subjects with AF was at most risk of stroke-related death (HR, 6.609; 95% CI, 3.794À9.725). Interpretation: Incident AF is associated with an increased risk of SCA and NSCD in the HCM population. Early detection of AF may provide more comprehensive risk stratification of SCD in HCM population. Because of underuse of oral anticoagulants and the absence of primary prevention ICD therapy in our cohort, the application of our findings was limited for the general HCM population in the current clinical practice.

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Section: Discussionmentioning

confidence: 99%

Atrial fibrillation and the risk of sudden cardiac arrest in patients with hypertrophic cardiomyopathy - A nationwide cohort study

Liao

Juang

et al. 2021

EClinicalMedicine

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“…Short-term (DFA α 1 ) and long-term (DFA α 2 ) scaling exponents were determined in both groups for different box sizes 4 < n < 11 and 12 < n < 64, respectively [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Classical heart rate variability and non-linear heart rate analysis in mice under Na-Pentobarbital and Ketamine/Xylazine anesthesia.

KAZDAĞLI¹,

ÖZEL²,

ÖZBEK³

et al. 2022

Turkish Journal of Medical Sciences

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Background/aim Anesthetics are often used in animal experiments to achieve immobilization and relieve pain. However, many anesthetics can alter the dynamics of cardiovascular systems. We aimed to compare the effects of two frequently used anesthetics agents on heart rate variability (HRV) parameters in mice. Materials and methods This observational study was performed between May and June 2014 in 21 male BALB/c mice aged 16–20 weeks. The animals were divided into three groups: pentobarbital (P), (n = 7); pentobarbital+fentanyl (P+F), (n = 7); and ketamine+xylazine (K+X), (n = 7). Surface electrocardiography (ECG) electrodes were placed in lead II configuration. The tachogram of RR intervals was obtained after R waves were detected using the Pan-Tompkins real-time QRS recognition algorithm. Frequency-domain, time-domain, and nonlinear HRV analyses were performed. Results The bradycardia effect was higher in the K+X group (p < 0.01). Time-domain indices were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). Very low frequency (VLF) power was significantly lower in group K+X compared to group P and group P+F (p < 0.01). Low frequency (LF) power, low frequency/high frequency (LF/HF) ratio, and total power (TP) were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). The detrended fluctuation analysis short-term parameter (DFAα 1 ) was significantly higher in group K+X compared to group P+F (p < 0.05) and the long-term parameter (DFAα 2 ) was lower in group K+X compared to group P (p < 0.05). Standard deviations SD1 and SD2 were higher in group K+X compared to group P (p < 0.001) and group P+F (p < 0.001), SD2/SD1 ratio was lower in group K+X compared to group P (p < 0.05) and group P+F (p < 0.05). Entropy measures did not differ between groups. Conclusion HRV analyses, including nonlinear methods, indicated that a K+X combination reduces imbalance and disorder in the regulation of the autonomic nervous system (ANS) in comparison to both P and the P+F combination.

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“…Additionally, both clinical and biochemical markers of RA disease activity correlate with the degree of autonomic dysfunction (7,75,156). Animal models of inflammatory arthritis also demonstrate that autonomic dysfunction can occur even when overt joint disease is apparently in remission (88).…”

Section: Autonomic Dysfunction In Ramentioning

confidence: 97%

Proarrhythmic electrophysiological and structural remodeling in rheumatoid arthritis

Patel

Jones

Sattler

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

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Chronic inflammatory disorders, including rheumatoid arthritis (RA), are associated with a two-fold increase in the incidence of sudden cardiac death (SCD) compared to the healthy population. Although this is partly explained by an increased prevalence of coronary artery disease, growing evidence suggests that ischaemia alone cannot completely account for the increased risk. The present review explores the mechanisms of cardiac electrophysiological remodelling in response to chronic inflammation in RA. In particular, it focuses on the roles of non-ischaemic structural remodelling, altered cardiac ionic currents and autonomic nervous system dysfunction in ventricular arrhythmogenesis and SCD. It also explores whether common genetic elements predispose to both RA and SCD. Finally, it evaluates the potential dual effects of disease-modifying therapy in both diminishing and promoting the risk of ventricular arrhythmias and SCD.

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Proarrhythmic risk and determinants of cardiac autonomic dysfunction in collagen-induced arthritis rats

Cited by 10 publications

References 35 publications

Atrial fibrillation and the risk of sudden cardiac arrest in patients with hypertrophic cardiomyopathy - A nationwide cohort study

Atrial fibrillation and the risk of sudden cardiac arrest in patients with hypertrophic cardiomyopathy - A nationwide cohort study

Classical heart rate variability and non-linear heart rate analysis in mice under Na-Pentobarbital and Ketamine/Xylazine anesthesia.

Proarrhythmic electrophysiological and structural remodeling in rheumatoid arthritis

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