“…It is well known that this operator is essential self-adjoint in L 2 (R n ) if and only if n ≥ 4, [47, p.114] and [39,Theorem X.11,p.161]. Generalizations of this example to manifolds have been provided in [12] and [34], more general examples on Euclidean spaces can be found in [5] and [25], further generalizations to manifolds and metric measure spaces will be discussed in [26]. For the Laplacian on R n one main observation is that, if a compact set Σ of zero measure is removed from R n , the essential self-adjointness of (∆, C ∞ c (R n \ Σ)) in L 2 (R n ) implies that dim H Σ ≤ n − 4, where dim H denotes the Hausdorff dimension.…”