Probabilistic kinetic model of slow oxidation of low-density lipoprotein: I. Theory

Probabilistic Kinetic Model of Slow Oxidation of Low-Density Lipoprotein. 3. Hydroperoxide-Free Initiation

“…Parameter r was varied from 0.001 to 0.999. Other parameters used in the calculations were the same as for the quasi-stationary model . The system is assumed to be closed (no supply of additional oxygen).…”

Slow oxidation of high density lipoproteins as studied by EPR spectroscopy

“…To conclude, it is obvious that the copper-induced oxidation of HDL is a rather complex process and that our theoretical model of LDL oxidation [19] is not appropriate for the description of the kinetics of the HDL oxidation. The probabilistic kinetic model is based on the concept of LDL particles as distinctive compartments with only weak inter-particle interaction between the oxidation bursts.…”

“…In our earlier studies, we demonstrated that copper could also initiate oxidation of LDL in a closed system with a defined and limited amount of oxygen and a with very small concentration of copper ions (the Cu 2+ ion to LDL molar ratio was within the range of 0.01 to 0.2) [16,17]. The main features of the temporal behavior of several oxidation markers (oxygen consumption, free radical generation, lipid hydroperoxide formation and α-tocopherol concentration) were explained in terms of the tocopherol-mediated peroxidation (TMP), initiated by traces of transition metal ions associated with LDL particles [18,19]. The developed probabilistic kinetic model could simulate slow and mild LDL oxidation under unfavorable oxidizing conditions that could be physiologically relevant.…”

Kinetic modeling of low density lipoprotein oxidation in arterial wall and its application in atherosclerotic lesions prediction

“…The mechanistic interpretation by conjugated diene versus time is rather difficult mainly due to the involvement of free radical intermediates (Eremia et al, 2008;Stocker and Keaney, 2004). Thomas et al (1997), Herak et al (2004), Stocker and Keaney (2004) and Horsley et al (2007) showed that a set of elementary reactions and the associated rate constants could provide a simple model for the process. This approach is used here in order to develop a simple expression for the reaction rate that can be used in the mass transfer equation of intima.…”

“…This model was used to study the effects of LDL oxidation in atherosclerosis process development. After that, Herak et al (2004) presented a theoretical model for simulating LDL oxidation by assuming ␣-tocopherol as a pro-oxidant. Herak's model experimentally interpreted by Krilov et al (2004).…”