To investigate patient outcomes following hospitalization for out-of-hospital cardiac arrest (OHCA) in the United States. We used the 2002 to 2013 Nationwide Inpatient Sample database to identify adults ≥ 18 years old with an ICD-9-CM principal diagnosis code of cardio-respiratory arrest (427.5) or ventricular fibrillation (VF) (427.41). In 4 pre-defined federal geographic regions: Northeast, Midwest, South and West, means and proportions of survival, survival stratified by initial rhythm, hospital charges and cost were estimated. Multiple linear and logistic regression models were conducted. Of 154,177 OHCA patients hospitalized in the U.S, 25,873 (16.8%) were in the Northeast, 38,296 (24.8%) in the Midwest, 57,305 (37.2%) in the South, and 32,703 (21.2%) in the West. Variability in survival was noted in VF arrests; compared to the Northeast, survival was higher in the Midwest and South [AOR 1.16, 95% CI (1.02–1.32) and AOR 1.24, 95% CI (1.09–1.40) respectively], with no difference detected in the West [AOR 0.93, 95% CI (0.82–1.06)]. No variability in survival was noted following non-VF arrests (p > 0.05). Hospital charges rose significantly across all regions of the United States (P-trend < 0.001), and were higher in the West as compared with the Northeast [(Hospital charges >$109,000/admission, AOR 1.76; 95% CI (1.50–2.06)]. In conclusion, Nationwide, we observed significant regional variability in survival of hospitalized patients following out of hospital VF cardiac arrest, no survival variability following non-VF arrests and a steady increase in hospital charges.