Probabilistic Modeling of Dietary Arsenic Exposure and Dose and Evaluation with 2003–2004 NHANES Data

Xue, Jianping; Zartarian, Valerie; Wang, Sheng Wei; Liu, Shi V.; Georgopoulos, Panos G.

doi:10.1289/ehp.0901205

Cited by 180 publications

(138 citation statements)

References 25 publications

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“…e l s e v i e r . c o m / l o c a t e / f o o d c h e m t o x chromated copper arsenate -treated wood (Meacher et al, 2002;Schoof et al, 1999;Tsuji et al, 2007;Xue et al, 2010;Yost et al, 2004). Contaminated drinking water is the largest source of exposure to As in regions where contamination is a problem even at moderate levels (Meliker et al, 2006), whereas rice is the largest iAs source in regions where drinking water As exposure is low (Fontcuberta et al, 2011;Meacher et al, 2002;Meliker et al, 2006;Tsuji et al, 2007;Xue et al, 2010).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…Studies have been pointing out the role of rice in people's exposure to arsenic (Meacher et al, 2002;Meharg et al, 2009;Meliker et al, 2006;Schoof et al, 1999;Sun et al, 2008;Tsuji et al, 2007;Williams et al, 2007b;Xue et al, 2010;Yost et al, 2004;Zhu et al, 2008), and consumer groups have been calling for a Maximum Contaminant Level (MCL) (Jalonick, 2012). While no MCL is in place in the US and the EU, China promulgates an MCL of 150 ng/g for iAs (Qian et al, 2010), and Hungary and China have 300 ng/g and 700 ng/g, respectively for tAs (Mihucz et al, 2007;Qian et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Speciated arsenic concentrations, exposure, and associated health risks for rice and bulgur

Sofuoğlu

Güzelkaya

Akgül

et al. 2014

Food and Chemical Toxicology

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a b s t r a c tArsenic species were determined in rice and bulgur samples that were collected from 50 participants who also supplied exposure related information through a questionnaire survey. Speciation analysis was conducted using an HPLC-ICP-MS system. Ingestion exposure to arsenic and associated health risks were assessed by combining the concentration and questionnaire data both for individual participants and the subject population. Inorganic arsenic dominated both in rice and bulgur but concentrations were about an order of magnitude higher in rice (160 ± 38 ng/g) than in bulgur. Because participants also consumed more rice than bulgur, exposures were significantly higher for rice resulting in carcinogenic risks above acceptable level for 53% and 93% of the participants when the in-effect and the proposed potencies were used, respectively, compared to 0% and 5% for bulgur. An inorganic arsenic standard for rice would be useful to lower the risks while public awareness about the relation between excessive rice consumption and health risks is built, and bulgur consumption is promoted.

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Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Speciated arsenic concentrations, exposure, and associated health risks for rice and bulgur

Sofuoğlu

Güzelkaya

Akgül

et al. 2014

Food and Chemical Toxicology

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“…The principal exposures routes for As are via drinking water, foods and inhaled particulates (Mondal et al, 2010), with many studies detailing the importance of the food pathway to overall As body burdens (Georgopoulos et al, 2007;Meacher et al, 2002;Mondal et al, 2010;Schoof et al, 1999;Xue et al, 2010). In West Bengal (India) it has been shown that even for populations exposed to high As levels in the drinking water, rice constitutes a major source of iAs in the diet (Mondal and Polya, 2008).…”

Section: Introductionmentioning

confidence: 99%

Inorganic arsenic in Chinese food and its cancer risk

Sun

Williams

et al. 2011

Environment International

355

160

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Even moderate arsenic exposure may lead to health problems, and thus quantifying inorganic arsenic (iAs) exposure from food for different population groups in China is essential. By analyzing the data from the China National Nutrition and Health Survey (CNNHS) and collecting reported values of iAs in major food groups, we developed a framework of calculating average iAs daily intake for different regions of China. Based on this framework, cancer risks from iAs in food was deterministically and probabilistically quantified. The article presents estimates for health risk due to the ingestion of food products contaminated with arsenic. Both per individual and for total population estimates were obtained. For the total population, daily iAs intake is around 42 μg day − 1 , and rice is the largest contributor of total iAs intake accounting for about 60%.Incremental lifetime cancer risk from food iAs intake is 106 per 100,000 for adult individuals and the median population cancer risk is 177 per 100,000 varying between regions. Population in the Southern region has a higher cancer risk than that in the Northern region and the total population. Sensitive analysis indicated that cancer slope factor, ingestion rates of rice, aquatic products and iAs concentration in rice were the most relevant variables in the model, as indicated by their higher contribution to variance of the incremental lifetime cancer risk. We conclude that rice may be the largest contributor of iAs through food route for the Chinese people. The population from the South has greater cancer risk than that from the North and the whole population.

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“…This finding suggests that incorporating water consumption may improve prediction of arsenic in urine. Likewise, intake of water, beverages or foods made with tap water, or the consumption of other foods, such as fish, also influence arsenic exposure (Xue et al, 2010) and the amount of arsenic excreted in urine.…”

Section: Introductionmentioning

confidence: 99%

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Rivera‐Núñez

Meliker

Meeker

et al. 2011

J Expo Sci Environ Epidemiol

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The large disparity between arsenic concentrations in drinking water and urine remains unexplained. This study aims to evaluate predictors of urinary arsenic in a population exposed to low concentrations (r50 mg/l) of arsenic in drinking water. Urine and drinking water samples were collected from a subsample (n ¼ 343) of a population enrolled in a bladder cancer case-control study in southeastern Michigan. Total arsenic in water and arsenic species in urine were determined using ICP-MS: arsenobetaine (AsB), arsenite ( A separate analysis indicated that AsB and DMA [V] were significantly correlated with fish and shellfish consumption, which may suggest that seafood intake influences DMA[V] excretion. The Spearman correlation between arsenic concentration in toenails and SumAs was 0.36 and between arsenic concentration in toenails and arsenic concentration in water was 0.42. Results show that arsenic exposure from drinking water consumption is an important determinant of urinary arsenic concentrations, even in a population exposed to relatively low levels of arsenic in drinking water, and suggest that seafood intake may influence urinary DMA [V] concentrations.

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Probabilistic Modeling of Dietary Arsenic Exposure and Dose and Evaluation with 2003–2004 NHANES Data

Cited by 180 publications

References 25 publications

Speciated arsenic concentrations, exposure, and associated health risks for rice and bulgur

Speciated arsenic concentrations, exposure, and associated health risks for rice and bulgur

Inorganic arsenic in Chinese food and its cancer risk

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

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