With the increasing interest in vertical ground motions, the focus of this study is to investigate the effect of concurrent horizontal-vertical excitations on the seismic response and collapse fragilities of RC buildings designed according to modern seismic codes and located near active faults. It must be stressed that only mid-to high-rise buildings are of significant concern in the context of this research. The considered structures are categorized as intermediate and special RC-MRFs and have been remodeled using distributed and lumped plasticity computational approaches in nonlinear simulation platforms, so that the utilized NL models can simulate all possible modes of deterioration. For better comparison, not only was the combined vertical and horizontal motion applied, but also a single horizontal component was considered for direct evaluation of the effect of the vertical ground motions (VGMs). At the member level, axial force variation and shear failure as the most critical brittle failure mechanisms were studied, while on the global level, adjusted collapse margin ratios (ACMRs) and mean annual frequency of collapse (k Collapse ) using a new vector-valued intensity measure were investigated. Findings from the study indicate that VGMs have significant effects on both local and global structural performance and cannot be neglected.