Probabilistic White Matter Atlases of Human Auditory, Basal Ganglia, Language, Precuneus, Sensorimotor, Visual and Visuospatial Networks

Figley, Teresa D.; Moghadam, Behnoush Mortazavi; Bhullar, Navdeep; Kornelsen, Jennifer; Courtney, Susan; Figley, Chase R.

doi:10.3389/fnhum.2017.00306

Cited by 36 publications

(29 citation statements)

References 45 publications

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“…7 , top). 80 There was a significant positive correlation between baseline drift rate v 0 and FA within the apathy network, but not the two control networks ( Fig. 7 , bottom left), even after correcting for multiple comparison [ F (1,58) = 14.58, P = 0.0009] indicating that integrity of those tracts is associated with higher rate of evidence accumulation to accept offers.…”

Section: Resultsmentioning

confidence: 95%

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Saleh

Heron

Petitet

et al. 2021

Brain

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Patients with small vessel cerebrovascular disease frequently suffer from apathy, a debilitating neuropsychiatric syndrome, the underlying mechanisms of which remain to be established. Here we investigated the hypothesis that apathy is associated with disrupted decision making in effort-based decision making, and that these alterations are associated with abnormalities in the white matter network connecting brain regions that underpin such decisions. Eighty-two patients with MRI evidence of small vessel disease were assessed using a behavioural paradigm as well as diffusion weighted MRI. The decision-making task involved accepting or rejecting monetary rewards in return for performing different levels of physical effort (hand grip force). Choice data and reaction times were integrated into a drift diffusion model that framed decisions to accept or reject offers as stochastic processes approaching a decision boundary with a particular drift rate. Tract-based spatial statistics were used to assess the relationship between white matter tract integrity and apathy, while accounting for depression. Overall, patients with apathy accepted significantly fewer offers on this decision-making task. Notably, while apathetic patients were less responsive to low rewards, they were also significantly averse to investing in high effort. Significant reductions in white matter integrity were observed to be specifically related to apathy, but not to depression. These included pathways connecting brain regions previously implicated in effort-based decision making in healthy people. The drift rate to decision parameter was significantly associated with both apathy and altered white matter tracts, suggesting that both brain and behavioural changes in apathy are associated with this single parameter. On the other hand, depression was associated with an increase in the decision boundary, consistent with an increase in the amount of evidence required prior to making a decision. These findings demonstrate altered effort-based decision making for reward in apathy, and also highlight dissociable mechanisms underlying apathy and depression in small vessel disease. They provide clear potential brain and behavioural targets for future therapeutic interventions, as well as modelling parameters that can be used to measure the effects of treatment at the behavioural level.

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Section: Resultsmentioning

confidence: 95%

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Saleh

Heron

Petitet

et al. 2021

Brain

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“…Reduced functional connectivity may be due to reduced cognitive and other functions, and the increase in functional connectivity between networks may be due to the compensatory mechanism of the functional network (Damoiseaux, 2017; Ferreira & Busatto, 2013; Naik, Banerjee, Bapi, Deco, & Roy, 2017; Vij et al., 2018). Furthermore, BGN is associated with a variety of functions, including motor, cognitive, motivational, and emotional processes (Doya, 2000), and has overlapping several functions with other networks, especially with SMN which could be expected that BGN may compensate to the dysfunction of SMN (Figley, 2017; Yanagisawa, 2018). Meanwhile, Regners et al also found that increased effective connectivity from dDMN to BGN in long‐term abstinence may be a compensatory mechanism related to behavioral monitoring (Castellazzi, 2014; Regner et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Alterations of local functional connectivity in lifespan: A resting‐state fMRI study

Wen

Dong

et al. 2020

Brain and Behavior

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Introduction As aging attracted attention globally, revealing changes in brain function across the lifespan was largely concerned. In this study, we aimed to reveal the changes of functional networks of the brain (via local functional connectivity, local FC) in lifespan and explore the mechanism underlying them. Materials and Methods A total of 523 healthy participants (258 males and 265 females) aged 18–88 years from part of the Cambridge Center for Ageing and Neuroscience (CamCAN) were involved in this study. Next, two data‐driven measures of local FC, local functional connectivity density (lFCD) and four‐dimensional spatial‐temporal consistency of local neural activity (FOCA), were calculated, and then, general linear models were used to assess the changes of them in lifespan. Results Local functional connectivity (lFCD and FOCA) within visual networks (VN), sensorimotor network (SMN), and default mode network (DMN) decreased across the lifespan, while within basal ganglia network (BGN), local connectivity was increased across the lifespan. And, the fluid intelligence decreased within BGN while increased within VN, SMN, and DMN. Conclusion These results might suggest that the decline of executive control and intrinsic cognitive ability in the aging population was related to the decline of functional connectivity in VN, SMN, and DMN. Meanwhile, BGN might play a regulatory role in the aging process to compensate for the dysfunction of other functional systems. Our findings may provide important neuroimaging evidence for exploring the brain functional mechanism in lifespan.

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“…These ventral workflow pathways subserve our regions of interest (temporal pole; TOJ; IFG). In addition, arcuate fasciculus is also classically implicated in connectivity between pSTS-TOJ and pars triangularis (Figley et al, 2017). Exploring the functional connectivity between these regions during phrase composition, we computed phase-locking values (PLV) for electrode pairs situated within pSTS-TOJ and either pars triangularis or anterior temporal lobe.…”

Section: Resultsmentioning

confidence: 99%

Minimal phrase composition revealed by intracranial recordings

Murphy

Woolnough

et al. 2021

Preprint

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The ability to comprehend meaningful phrases is an essential component of language. Here we evaluate a minimal compositional scheme – the ‘red-boat’ paradigm – using intracranial recordings to map the process of semantic composition in phrase structure comprehension. 18 human participants, implanted with penetrating depth or surface subdural intracranial electrode for the evaluation of medically refractory epilepsy, were presented with auditory recordings of adjective-noun, pseudoword-noun and adjective-pseudoword phrases before being presented with a colored drawing, and were asked to judge whether the phrase matched the object presented. Significantly greater broadband gamma activity (70-150Hz) occurred in temporo-occipital junction (TOJ) and posterior middle temporal gyrus (pMTG) for pseudowords over words (300-700ms post-onset) in both first- and second-word positions. Greater inter-trial phase coherence (8-12Hz) was found for words than for pseudowords in posterior superior temporal gyrus (pSTG). Isolating phrase structure sensitivity, we identified a portion of TOJ and posterior superior temporal sulcus (pSTS) that showed increased gamma activity for phrase composition than for non-composition, while left anterior temporal lobe (ATL) showed greater low frequency (2-15Hz) activity for phrase composition, likely coordinating distributed semantic representations. Greater functional connectivity between pSTS-TOJ and pars triangularis, and between pSTS-TOJ and ATL, was also found for phrase composition. STG, ATL and pars triangularis were found to encode anticipation of composition in the beta band (15-30Hz), and alpha (8-12Hz) power increases in ATL were also linked to anticipation. These results indicate that pSTS-TOJ appears to be crucial hub in the network responsible for the retrieval and computation of minimal phrases, and that anticipation of such composition is encoded in fronto-temporal regions.

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Probabilistic White Matter Atlases of Human Auditory, Basal Ganglia, Language, Precuneus, Sensorimotor, Visual and Visuospatial Networks

Cited by 36 publications

References 45 publications

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making

Alterations of local functional connectivity in lifespan: A resting‐state fMRI study

Minimal phrase composition revealed by intracranial recordings

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