Probability curves for predicting symptom severity during oral food challenge with milk

Increasing specific immunoglobulin E levels correlate with the risk of anaphylaxis during an oral food challenge

“…The present study is the first to determine that a higher sIgE level produced in response to causative foods is a risk factor for an anaphylactic reaction during an OFC among OFC‐positive patients. The present study also confirmed that a higher sIgE level produced in response to causative foods is a risk factor for an anaphylactic reaction among all patients who undergo an OFC, consistent with previous studies . Several studies have shown that the severity of symptoms during an OFC is associated with higher sIgE levels for the causative foods .…”

“…The present study also confirmed that a higher sIgE level produced in response to causative foods is a risk factor for an anaphylactic reaction among all patients who undergo an OFC, consistent with previous studies . Several studies have shown that the severity of symptoms during an OFC is associated with higher sIgE levels for the causative foods . However, in these studies, OFC‐negative patients and OFC‐positive patients were compared and severe OFC‐induced symptoms were rare.…”

“…A history of anaphylaxis to causative foods, being older, and having an allergy to food other than eggs were reported as risk factors for a severe reaction during a double‐blind placebo‐controlled food challenge (DBPCFC) . In addition, higher specific immunoglobulin E (sIgE) levels to causative foods have been associated with a positive OFC and the severity level of the anaphylactic reaction among all patients who underwent an OFC (OFC‐negative and OFC‐positive patients) . However, as these previous studies evaluated all patients, including challenge‐negative patients, the identified risk factors for anaphylaxis may include the risk factors for a positive OFC.…”

Follow‐up of patients with uncertain symptoms during an oral food challenge is useful for diagnosis

“…In our study, 20% of cases were uncertain, and however, the ratio of mild symptoms during Open‐OFC may depend on the patient's backgrounds; therefore, it is appropriate compared with previous reports …”

“…In our study, 20% of cases were uncertain, and however, the ratio of mild symptoms during Open-OFC may depend on the patient's backgrounds; therefore, it is appropriate compared with previous reports. 23,24 T A B L E 3 Symptoms that developed at home in cases who were intolerant to causative foods The total numbers might equal more than the total sample because more than 1 symptom could be experienced by each case. OFC, oral food challenge.…”