Probability distribution of sibship determination with ABI Identifiler multiplex system using different software

Caenazzo, Luciana; Cerri, N.; Ponzano, E.; Sbrignadello, Stefano; Benciolini, Paolo; Verzeletti, Andrea; Ferrari, Francesco; Presciuttini, Silvano

doi:10.1016/j.ics.2005.10.037

International Congress Series

2006

DOI: 10.1016/j.ics.2005.10.037

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Probability distribution of sibship determination with ABI Identifiler multiplex system using different software

Luciana Caenazzo

N. Cerri

E. Ponzano

et al.

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2012

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“…Previous studies ( 6 - 13 ) undertook DNA typing of known genetic relatives from which they made conclusions of putative sibling identification. These studies are necessarily limited by the availability of data.…”

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confidence: 99%

A novel strategy for sibship determination in trio sibling model

Lee¹,

Lin²,

Tsai³

et al. 2012

Croat Med J

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AimTo use a virtually simulated population, generated from published allele frequencies based on 15 short tandem repeats (STR), to evaluate the efficacy of trio sibship testing and sibling assignment for forensic purposes.MethodsVirtual populations were generated using 15 STR loci to create a large number of related and unrelated genotypes (10 000 trio combinations). Using these virtual populations, the probability of related and unrelated profiles can be compared to determine the chance of inclusions of being siblings if they are true siblings and the chance of inclusion if they are unrelated. Two specific relationships were tested – two reference siblings were compared to a third true sibling (3S trio, sibling trio) and two reference siblings were compared to an unrelated individual (2S1U trio, non-sibling trio).ResultsWhen the likelihood ratio was greater than 1, 99.87% of siblings in the 3S trio population were considered as siblings (sensitivity); 99.88% of non-siblings in the 2S1U trio population were considered as non-siblings (specificity); 99.9% of both populations were identified correctly as siblings and non-siblings; and the accuracy of the test was 99.88%.ConclusionsThe high sensitivity and specificity figures when using two known siblings compared to a putative sibling are significantly greater than when using only one known relative. The data also support the use of increasing number of loci allowing for greater confidence in genetic identification. The system established in this study could be used as the model for evaluating and simulating the cases with multiple relatives.

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mentioning

confidence: 99%

A novel strategy for sibship determination in trio sibling model

Lee¹,

Lin²,

Tsai³

et al. 2012

Croat Med J

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Probability distribution of sibship determination with ABI Identifiler multiplex system using different software

Cited by 1 publication

References 8 publications

A novel strategy for sibship determination in trio sibling model

A novel strategy for sibship determination in trio sibling model

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