Probability distribution of the number of deceits in collective robotics

Murciano, Antonio; Zamora, Javier Flores; López-Sánchez, Jesús; Rodriguez-Santamaria, Emilia

doi:10.1017/s0021900200021896

Cited by 1 publication

(5 citation statements)

References 6 publications

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“…PCR amplification was performed as described by Murciano et al (Murciano et al, 2002 (Murciano et al, 2002). Gapdh was amplified for 28 cycles, whereas the other genes were amplified for 29-35 cycles.…”

Section: Reverse Transcriptase-polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

“…The digoxigenin-labeled antisense riboprobes for chick Dll1, Notch1 and lunatic Fringe (lFng) were synthesized as described previously (Murciano et al, 2002;Cisneros et al, 2008). Atoh7 and Pou4f3 digoxigenin-labeled antisense riboprobes were obtained from linearized plasmid templates using T7 or Sp6 RNA polymerases as appropriate (Promega) following the manufacturer's instructions.…”

Section: In Situ Hybridizationmentioning

confidence: 99%

“…Atoh7 and Pou4f3 digoxigenin-labeled antisense riboprobes were obtained from linearized plasmid templates using T7 or Sp6 RNA polymerases as appropriate (Promega) following the manufacturer's instructions. In situ hybridization was performed as described previously (Murciano et al, 2002).…”

Section: In Situ Hybridizationmentioning

confidence: 99%

“…We have modeled the developing retina as a two-dimensional tissue of irregularly shaped cells ( Fig. 2A-C), where, for simplicity, we do not consider interkinetic nuclear movement (Murciano et al, 2002;Norden et al, 2009), cell death or cell division. Developmental events occurring after the advance of the initial neurogenic wave are out of the scope of our work.…”

Section: Dll1 Is Expressed Before the Initiation Of Neurogenesis In Tmentioning

confidence: 99%

“…Therefore, the conditions at the wavefront are expected to have relevant consequences for the final pattern of neuronal differentiation. Although the importance of static boundary conditions at the borders of a pattern-forming tissue have received some theoretical notice (Honda et al, 1990;Collier et al, 1996;Murciano et al, 2002;Meir et al, 2002;Plahte, 2001), moving wavefronts of lateral inhibition have only recently come to attention (Owen, 2002;Plahte and Øyehaug, 2007;Pennington and Lubensky, 2010;O'Dea and King, 2011;Lubensky et al, 2011). These studies show how a neurogenic wavefront can sweep across a field of identical cells and leave behind a pattern of different cell types.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of neuronal differentiation at the neurogenic wavefront

et al. 2012

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SUMMARYSignaling mediated by the Delta/Notch system controls the process of lateral inhibition, known to regulate neurogenesis in metazoans. Lateral inhibition takes place in equivalence groups formed by cells having equal capacity to differentiate, and it results in the singling out of precursors, which subsequently become neurons. During normal development, areas of active neurogenesis spread through non-neurogenic regions in response to specific morphogens, giving rise to neurogenic wavefronts. Close contact of these wavefronts with non-neurogenic cells is expected to affect lateral inhibition. Therefore, a mechanism should exist in these regions to prevent disturbances of the lateral inhibitory process. Focusing on the developing chick retina, we show that Dll1 is widely expressed by non-neurogenic precursors located at the periphery of this tissue, a region lacking Notch1, lFng, and differentiation-related gene expression. We investigated the role of this Dll1 expression through mathematical modeling. Our analysis predicts that the absence of Dll1 ahead of the neurogenic wavefront results in reduced robustness of the lateral inhibition process, often linked to enhanced neurogenesis and the presence of morphological alterations of the wavefront itself. These predictions are consistent with previous observations in the retina of mice in which Dll1 is conditionally mutated. The predictive capacity of our mathematical model was confirmed further by mimicking published results on the perturbation of morphogenetic furrow progression in the eye imaginal disc of Drosophila. Altogether, we propose that Notch-independent Delta expression ahead of the neurogenic wavefront is required to avoid perturbations in lateral inhibition and wavefront progression, thus optimizing the neurogenic process.

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Section: Reverse Transcriptase-polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

Section: In Situ Hybridizationmentioning

confidence: 99%

Section: In Situ Hybridizationmentioning

confidence: 99%

Section: Dll1 Is Expressed Before the Initiation Of Neurogenesis In Tmentioning

confidence: 99%