Probability of Detecting a Granuloma in a Colorectal Biopsy of Crohn's Disease

Lymphatics, tertiary lymphoid organs and the granulomas of Crohn’s disease: an immunohistochemical study

“…Herein, we report the frequency in ileum. Our finding of granulomas in 79% of diseased ilea is consistent with other reports in the literature 7, 36, 39–43 …”

“…Others found little or no difference, no difference in extraintestinal manifestations, complications or recurrence rates, when comparing patients with and without granulomas 24, 36, 37 . There is more uniformity of opinion that granulomatous disease occurs in younger patients, first seen between the ages of 0–19 years, and that granulomas occur with increasing frequency in the more distal portions of intestine 20, 36, 38–40 . Herein, we report the frequency in ileum.…”

“…24,36,37 There is more uniformity of opinion that granulomatous disease occurs in younger patients, first seen between the ages of 0-19 years, and that granulomas occur with increasing frequency in the more distal portions of intestine. 20,36,[38][39][40] Herein, we report the frequency in ileum. Our finding of granulomas in 79% of diseased ilea is consistent with other reports in the literature.…”

“…Our finding of granulomas in 79% of diseased ilea is consistent with other reports in the literature. 7,36,[39][40][41][42][43] Maybe it makes no difference whether patients have predominantly lymphocytic lymphangitis with TLOs or predominantly granulomatous disease. Others have shown little difference in the outcomes.…”

The Diagnosis of Gastroduodenal Crohn's Disease by Endoscopic Biopsy

“…Gastric granuloma was also found to be significantly more frequent in young patients or in those with brief duration of the disease (10). It has been reported that the value of serial sections in increasing the yield of granuloma is wellestablished in colorectal (15) but not in gastroduodenal biopsies (16). In our material no granuloma was discovered by semiserial sections in cases in which it was originally absent.…”