Probability of New-Onset Cancer Between Patients with Traumatic Brain Injury and a Comparison General Population Cohort

Wee, Hsiao-Yue; Ho, Chung‐Han; Chang, Ching-Hung; Chio, Chung-Ching; Wang, Jhi‐Joung; Wang, Che-Chuan; Kuo, Jinn‐Rung

doi:10.1016/j.wneu.2018.09.229

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…However, the starting time point of malignant development is difficult to determine; therefore, we set the beginning of the observation period to 2000. Consistent with our previous study, the mean time from TBI to cancer diagnosis was 4.8 years among mild TBI patients and 5.0 years among moderate/severe TBI patients; these durations are shorter than that among the general population, which is approximately 5.9 years [ 19 ]. Because it is hard to understand that cancer can occur within such a short period of time after a traumatic brain injury, we believe that cancer may also be a risk factor for brain injury, given that the cause and effect relationship needs to be clarified.…”

Section: Discussionsupporting

confidence: 88%

“…In Taiwan [ 17 ], the mortality rate of patients with cancer remains high and cancer is a leading cause of mortality for all populations [ 18 ]. A novel finding in our recent study indicated that TBI patients had a 1.27-fold higher risk for a new diagnosis of systemic cancer than those without TBI, and our TBI patients had greater frequencies of cancer in the head and neck structures [ 19 ]. Based on the concept that injury severity is a critical outcome predictor following TBI [ 20 , 21 ], whether the severity of TBI affects systemic malignant cancer development is worth investigating.…”

Section: Introductionmentioning

confidence: 99%

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New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study

Nyam

et al. 2022

BMC Cancer

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Background Traumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI on systemic cancer development has not been clarified. Methods A retrospective longitudinal cohort study was conducted using the Taiwan Longitudinal Health Insurance Database between January 2000 and December 2011. A total of 35,306 patients were initially enrolled, and 14,795 patients with mild TBI and 14,795 patients with moderate/severe TBI were matched using the National Health Insurance Research Database in Taiwan. The Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of TBI adjusted for potential confounding factors. Results After matching, the results showed that patients with moderate/severe TBI had a high mortality rate (17.7% vs. 10.4%) and shorter time interval from TBI to death (mean 3.6 years vs. 5.8 years). No differences were observed in cancer incidence (4.1% vs. 4.1%) or risk factors for mortality between mild and moderate/severe TBI patients. However, patients aged between 46 and 55 years, female patients, and patients with pre-existing renal disease had a significant higher cancer incidence risk in moderate/severe TBI compared with mild TBI patients. The top 15 most common cancers showed that mild TBI patients had a higher percentage of head and neck cancer. The overall mortality rate in all TBI patients diagnosed with cancer was about 50%, and the cancer-specific mortality is approximately 85% in death of TBI patients with cancer. Conclusions We concluded that the incidence risk of a new cancer diagnosis and mortality risk of TBI patients with cancer between the mild TBI and moderate/severe TBI patients were not significantly different.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study

Nyam

et al. 2022

BMC Cancer

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“…Both Chen et al [10] and Hu et al [11] conducted population-based studies and suggested a possible etiological relationship between THI and brain cancer. Further support was also presented in other work by Wee et al [62] who applied a regression analysis on a cohort of 34,556 patients with THI and 69,112 patients without THI over a period of 15 years in Taiwan. Their results showed that brain cancer incidence was higher in patients with THI (4.38%) in comparison to those without THI (3.88%).…”

Section: Discussionsupporting

confidence: 62%

“…To cope with unobserved/unmeasured covariates in this study, we adopted the approach generally utilized in Bayesian disease mapping and analysis where, spatially structured and spatially unstructured random effects are included in the regression model [73]. For future work, we intend to explore other potential significant risk factor covariates such as age and gender which may be related to the outcome variable [2,62,74]. Other factors including socio-economic status have shown some association with brain cancer in previous work and may also be considered for future research [75].…”

Section: Discussionmentioning

confidence: 99%

Bayesian Space–Time Analysis of Brain Cancer Incidence in Southern Ontario, Canada: 2010–2013

Persad¹

2019

Medical Sciences

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Canada has one of the highest incidence rates of brain cancer in the world. This study investigates the space–time variation of brain cancer risk across Southern Ontario, Canada. A Bayesian spatio-temporal regression model is used to estimate the relative risk of brain cancer in the 12 spatial health units of Southern Ontario over a four-year period (2010–2013). This work also explores the association between brain cancer and two potential risk factors: traumatic head injury (THI) and excess body fat (EBF). Across all areal units from 2010–2013, results show that the relative risk of brain cancer ranged from 0.83 (95% credible interval (CI) 0.74–0.91) to 1.26 (95% CI 1.13–1.41). Over the years, the eastern and western health units had persistently higher risk levels compared to those in the central areas. Results suggest that areas with elevated THI rates and EBF levels were also potentially associated with higher brain cancer relative risk. Findings revealed that the mean temporal trend for cancer risk progression in the region smoothly decreased over time. Overall, 50% of the health units displayed area-specific trends which were higher than the region’s average, thus indicating a slower decrease in cancer rates for these areas in comparison to the mean trend.

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The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study

Yeh

Hansen

et al. 2022

Cancer Epidemiology

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Probability of New-Onset Cancer Between Patients with Traumatic Brain Injury and a Comparison General Population Cohort

Cited by 4 publications

References 23 publications

New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study

New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study

Bayesian Space–Time Analysis of Brain Cancer Incidence in Southern Ontario, Canada: 2010–2013

The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study

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