The COVID-19 epidemic has had a huge impact on the mental state of human beings due to its high infection and fatality rates in early 2020. In this paper, a cross-sectional online survey was designed to understand the mental state of college students in a university located in Wuhan city during the lockdown. Out of 1168 respondents, above 50% participants had obvious fear and anxiety symptoms; anxiety and fear were 61.64% and 58.39%, respectively. Conformity (49.49%), invulnerability (26.11%), insensitivity (21.49%) and rebelliousness (12.41%) symptoms also appeared. Meanwhile, it was revealed that the senior students experienced more anxiety than the freshmen. Moreover, it was found that the psychological symptoms (except for the insensitivity symptom) had no significant difference in gender, residence and annual household income after the one-way analysis of variance.