Probable Case of Vertical Transmission of SARS-CoV-2 in a Newborn in Mexico

Mendoza-Hernández, Marcela; Rivera, Ivette Huerta-Niño de; Yoldi‐Negrete, María; Saviñon-Tejeda, Pamela; Franco-Cendejas, Rafael; López‐Jácome, Luis Esaú; Navarro-Castellanos, Iñaki

doi:10.1159/000514710

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Both neonates had negative PCR results at 23 and 48 hours, as in our study. Mendoza-Hernández et al 32 reported positive PCR tests in one case taken in the 36th hour after birth in a case with respiratory distress and pneumothorax. Another case, reported by Coronado et al, presented with respiratory distress, fever, cough, and nasal blockage in the 3rd week.…”

Section: Discussionmentioning

confidence: 97%

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

Gürel

Yıldırım

2022

J Pediatr Infect Dis

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Objective The epidemiological and clinical characteristics of neonates born to women infected with coronavirus disease 2019 (COVID-19) during pregnancy were assessed, and the correlation between this infection and spontaneous pneumothorax in neonates born to mothers with COVID-19 was evaluated in the present study. Methods Records of 14 neonates in the neonatal intensive care unit with pneumothorax were collected and analyzed. Pregnant women were routinely screened for COVID-19 before birth. This study only included the neonates of mothers positive for severe acute respiratory syndrome coronavirus 2 immunoglobulin Mand immunoglobulin G and developing spontaneous pneumothorax. Antenatal, natal and postnatal risk factors, data related to demographic, epidemiological and clinical characteristics, treatment strategies, and breastfeeding history were obtained from medical records. Results The gestational age of the 14 neonates was 30 to 38 weeks. One male infant was born by normal spontaneous vaginal delivery, while all other infants were born by C-section. Though the mothers did not have a diagnosis of COVID-19 in their charts, they all reported one or more symptoms when interviewed. No mother had received a COVID-19 vaccination before or during pregnancy. No mother had undergone a hospital visit or doctor examination due to suspicion of COVID and COVID polymerase chain reaction test. COVID antibody titers were present during admission to hospital before birth. Conclusion The infants of pregnant cases with symptomatic or asymptomatic COVID-19 may develop respiratory distress and pneumothorax. Observational data obtained from case series similar to what is presented here may be accepted as a potential first step to producing hypotheses to test with preclinical or clinical models if it can be expanded in larger cohorts.

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Section: Discussionmentioning

confidence: 97%

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

Gürel

Yıldırım

2022

J Pediatr Infect Dis

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“…Amniocentesis, umbilical cord blood, placenta, neonatal secretions, and breast milk samples were used to determine the vertical transmission of SARS‐CoV‐2 45 . Many investigations have demonstrated that newborn samples delivered by pregnant mothers with various levels of COVID‐19 infection tested positive for SARS‐CoV‐2 polymerase chain reaction (PCR), but perinatal transmission could not be ruled out 45–47 . Latest research findings appear to support this.…”

Section: Transmission Routes Of Sars‐cov‐2mentioning

confidence: 99%

“…45 Many investigations have demonstrated that newborn samples delivered by pregnant mothers with various levels of COVID-19 infection tested positive for SARS-CoV-2 polymerase chain reaction (PCR), but perinatal transmission could not be ruled out. [45][46][47] Latest research findings appear to support this. As immunoglobulin M (IgM) does not penetrate the placental barrier into the fetus, it was hypothesized that the fetus may have been infected with SARS-CoV-2 in utero based on analysis of neonatal blood samples collected 2 h after delivery from a pregnant woman diagnosed with COVID-19.…”

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confidence: 94%

A comprehensive overview on the transmission, pathogenesis, diagnosis, treatment, and prevention of SARS‐CoV‐2

Zhang

Clarke

et al. 2023

Journal of Medical Virology

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Severe acute respiratory syndrome coronavirus (SARS-CoV) is a single positivestrand RNA virus that is responsible for the current pandemic that the world has been facing since 2019. The primary route of transmission of SARS-CoV-2 is through respiratory tract transmission. However, other transmission routes such as fecal-oral, vertical transmission, and aerosol-eye also exist. In addition, it has been found that the pathogenesis of this virus involves the binding of the virus's S protein to its host cell surface receptor angiotensin-converting enzyme 2, which results in the subsequent membrane fusion that is required for SARS-CoV-2 to replicate and complete its entire life. The clinical symptoms of patients infected with SARS-CoV-2 can range from asymptomatic to severe. The most common symptoms seen include fever, dry cough, and fatigue. Once these symptoms are observed, a nucleic acid test is done using reverse transcription-polymerase chain reaction. This currently serves as the main confirmatory tool for COVID-19. Despite the fact that no cure has been found for SARS-CoV-2, prevention methods such as vaccines, specific facial mask, and social distancing have proven to be quite effective. It is imperative to have a complete understanding of the transmission and pathogenesis of this virus. To effectively develop new drugs as well as diagnostic tools, more knowledge about this virus would be needed.

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“…While vertical transmission of the virus has not been observed in an overwhelming number of cases, there is still potential for maternal immune activation [66]. When maternal immune activation occurs, it has been stated that an impact on the developing fetal brain is likely.…”

Section: Potential Adverse Effects On Fetusmentioning

confidence: 99%

Implications of COVID-19 Pandemic on Pregnancy: Current Status and Controversies

Greenberg,

Vishwakarma,

Tirupattur

et al. 2023

COVID

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The COVID-19 pandemic unnerved the global population in 2019 and has continued to evolve ever since. Throughout this time, investigations concerning the health of the groups most susceptible to this virus, including the elderly, those with compromised immunity or chronic diseases, and pregnant women, have taken place. Numerous articles have been formulated on the effects of COVID-19 infection on maternal, fetal, and neonatal health, but there are many controversies that still exist within the current literature. Even three years later, it is not fully understood how a maternal infection or vaccination of COVID-19 can impact pregnancy and the fetus, and these topics require further investigation and conclusive results. The aim of this article is to explain the risks for a mother and the neonate, during and after pregnancy, with the emergence of the COVID-19 pandemic. Additionally, this report presents the current state of the literature on whether vaccination during pregnancy is more beneficial or harmful. Finally, this review examines studies regarding the exacerbation of the effects of COVID-19 on pregnancies in various organ systems, particularly the cardiovascular system, in relevance to pre-existing and emerging conditions and the ethnicity of the mother.

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Probable Case of Vertical Transmission of SARS-CoV-2 in a Newborn in Mexico

Cited by 5 publications

References 18 publications

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

Increased Rate of Spontaneous Pneumothorax in Infants of COVID-19 Positive Mothers

A comprehensive overview on the transmission, pathogenesis, diagnosis, treatment, and prevention of SARS‐CoV‐2

Implications of COVID-19 Pandemic on Pregnancy: Current Status and Controversies

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