Probable disseminated Mycobacterium abscessus subspecies bolletii infection in a patient with idiopathic CD4+ T lymphocytopenia: a case report

Colomba, Claudia; Rubino, Raffaella; Carlo, Paola Di; Mammina, Caterina; Bonura, Celestino; Siracusa, Lucia; Titone, Lucina; Saporito, Laura

doi:10.1186/1752-1947-6-277

Cited by 6 publications

(4 citation statements)

References 18 publications

(27 reference statements)

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“…Mycobacterium abscessus subspecies bolletii together with Mycobacterium abscessus subspecies abscessus and Mycobacterium abscessus subspecies massiliense constitute the Mycobacterium abscessus group. These rapidly growing Mycobacteria (RGM) have been identified not only as sources of pulmonary infections but as sources of nosocomial, skin and soft tissue infections, osteoarticular infections as well as disseminated diseases in humans (Viana-Niero et al, 2008 ; Piersimoni and Scarparo, 2009 ; Zelazyn et al, 2009 ; Colombo et al, 2012 ). Another significance of these NTM is their high resistance to antibiotics (Nessar et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Non-tuberculous Mycobacteria in South African Wildlife: Neglected Pathogens and Potential Impediments for Bovine Tuberculosis Diagnosis

Gcebe

Hlokwe

2017

Front. Cell. Infect. Microbiol.

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Non-tuberculous mycobacteria (NTM) are not only emerging and opportunistic pathogens of both humans and animals, but from a veterinary point of view some species induce cross-reactive immune responses that hamper the diagnosis of bovine tuberculosis (bTB) in both livestock and wildlife. Little information is available about NTM species circulating in wildlife species of South Africa. In this study, we determined the diversity of NTM isolated from wildlife species from South Africa as well as Botswana. Thirty known NTM species and subspecies, as well as unidentified NTM, and NTM closely related to Mycobacterium goodii/Mycobacterium smegmatis were identified from 102 isolates cultured between the years 1998 and 2010, using a combination of molecular assays viz PCR and sequencing of different Mycobacterial house-keeping genes as well as single nucleotide polymorphism (SNP) analysis. The NTM identified in this study include the following species which were isolated from tissue with tuberculosis- like lesions in the absence of Mycobacterium tuberculosis complex (MTBC) implying their potential role as pathogens of animals: Mycobacterium abscessus subsp. bolletii, Mycobacterium gastri, Mycobacterium species closely related to Mycobacterium goodii/Mycobacterium smegmatis, Mycobacterium brasiliensis, Mycobacterium sinense JMD 601, Mycobacterium avium subsp. avium, Mycobacterium sp. GR-2007, Mycobacterium bouchedurhonense, and Mycobacterium septicum/M. peregrinum. Mycobaterium brasiliensis, Mycobacterium gastri, Mycobacterium sp. GR-2007, and a potential novel Mycobacterium species closely related to Mycobacterium goodii were found for the first time in this study to be potential pathogens of animals. Mycobacterium simiae was isolated from a sample originating from a tuberculin skin test positive reactor, demonstrating its potential to elicit inappropriate immune responses in animals that may interfere with diagnosis of tuberculosis by immunology. Mycobacterium abscessus subsp. bolletti was the most frequently detected NTM identified in 37 of the 102 isolates. Other NTM species were also isolated from animals not showing any pathological changes. Knowledge gained in this study contribute to the understanding of NTM species circulating in wild animals in South Africa and the pathogenic potential of certain species, whose role in disease causation need to be examined, as well as to a certain extent the potential of M. simiae to hamper the diagnosis of bTB.

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Section: Discussionmentioning

confidence: 99%

Non-tuberculous Mycobacteria in South African Wildlife: Neglected Pathogens and Potential Impediments for Bovine Tuberculosis Diagnosis

Gcebe

Hlokwe

2017

Front. Cell. Infect. Microbiol.

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“…Disseminated infection is rare and is usually seen in immunocompromised individuals. CNS localisation is very rare and is seen secondary to pulmonary disease [5].…”

Section: Discussionmentioning

confidence: 99%

“…abscessus is known to cause nosocomial infections, most commonly skin and soft-tissue abscess, secondary to trauma or injection with contaminated syringes, others being surgical wound infections, pulmonary infections, endocarditis, peritonitis and disseminated infection in patients on haemodialysis and in immunocompromised individuals [3] [4]. CNS infection due to M. abscessus is very rare and when present, is secondary to pulmonary infection [5].…”

Section: Introductionmentioning

confidence: 99%

A Case of Meningitis Caused by Mycobacterium abscessus in a Paediatric Patient

Devi¹,

Mallikarjuna²,

Chaturvedi³

et al. 2015

JTR

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Mycobacterium abscessus, a rapidly growing and potentially pathogenic Mycobacterium, is an environmental contaminant and is commonly found in tap water supplies. We report a case of M. abscessus meningitis following VP shunt insertion. A 9-year-old male patient with previous history of aqueductal stenosis and hydrocephalus with VP shunt in situ, presented with pain abdomen of 10 days duration. Investigations revealed multiple mesenteric lymph nodes with impacted VP shunt tip within the omentum. Ascitic fluid and CSF tap showed Acid-Fast Bacilli, later confirmed to be M. abscessus. The patient was treated with Clarithromycin and Amikacin, leading to resolution of the infection. To the best of our knowledge, this is the first reported case of M. abscessus meningitis in an immunocompetent individual. We discuss the possible sources of infection and therapeutic challenges. It is of utmost importance to consider, with high index of suspicion, nontubercular Mycobacteria as the causative organism in patients, who do not respond to regular anti-tubercular regimen.

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“…Mycobacterium abscessus is a gram positive [1], non-tuberculous mycobacterium having maximum similarity with Mycobacterium chelonae, due to this there was long time confusion in the identification of the species [2]. It is widely distributed in water, soil and animals [3].…”

Section: Introductionmentioning

confidence: 99%

In silico structural, functional and virtual screening study against proteasome subunit alpha of Mycobacterium abscessus subsp. bolletii as a drug target

Sahu,

Singh,

Gautam

et al. 2024

Preprint

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Many studies and observations suggest proteasomes are multimeric proteolytic enzyme complexes that play a central role in degradation of protein in animal cells. Several basic cellular processes such as the cell cycle, apoptosis, the stress response, and also the regulation of immune and inflammatory responses are concerned with it. In one of the studies, it was found that proteasome subunit alpha was identified as a drug target in Mycobacterium abscessus subsp. bolletii 50594. So we have predicted the proteasome subunit alpha structure of Mycobacterium abscessus subsp. bolletii in the present analysis via a Swiss-prot server. The primary and secondary structure analysis was performed through several webserver. The stereochemical quality of the model was evaluated by SAVES server. The compound ligand library was prepared with the help of the JSCG database and the Drug Bank. With the assistance of iGEMDock and AutoDock Vina tools, these ligands are used for virtual screening via protein-ligand docking. The result obtained by docking shows that there are several ligands from the prepared library, showing a much better interaction based on binding affinity. The pharmacokinetic analysis was also performed to predict out the ADMET properties and bioactivity of lead compound. It was noticeable from this outcome that there are certain ligands that could be used as a medication to treat the disease. These studies also enable us to discover a new potent anti-disease drug caused by Mycobacterium abscessus subsp. bolletii 50594.

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Probable disseminated Mycobacterium abscessus subspecies bolletii infection in a patient with idiopathic CD4+ T lymphocytopenia: a case report

Cited by 6 publications

References 18 publications

Non-tuberculous Mycobacteria in South African Wildlife: Neglected Pathogens and Potential Impediments for Bovine Tuberculosis Diagnosis

Non-tuberculous Mycobacteria in South African Wildlife: Neglected Pathogens and Potential Impediments for Bovine Tuberculosis Diagnosis

A Case of Meningitis Caused by Mycobacterium abscessus in a Paediatric Patient

In silico structural, functional and virtual screening study against proteasome subunit alpha of Mycobacterium abscessus subsp. bolletii as a drug target

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