Probable Iatrogenic Xanthotrichia

Fajardo, Nuria Martí; Llopis, Paula García; Ramón, R.; Monzó, Carmen Ortega

doi:10.1016/j.adengl.2014.07.001

Cited by 2 publications

(4 citation statements)

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“…Indeed, yellow-to-blond hair discoloration can occur secondary to a diversity of etiologic factors, including harmful environmental and occupational exposures, drugs, or systemic disease. In many individuals, however, the cause of their hair discoloration is difficult to establish [2,3]. We describe a white-haired woman who developed temporary yellow hair discoloration after sequential use of bacitracin zinc ointment and selenium sulfide 2.5% lotion.…”

Section: Introductionmentioning

confidence: 94%

“…Topical agents Anthralin (acidic conditions) [15] Minoxidil 1.5% [16] Selenium sulfide (with/without bacitracin) [8,17,18] Tar shampoo [7] Systemic drugs Chloroquine [2] Cisplatin [2] Heptaminol [19] Mephenesin [2] Minoxidil [20] para-aminobenzoic acid [2] Sunitinib [2] Tamsulosin [3] Valproic acid [2] Systemic conditions Essential fatty acid deficiency [21] a Malignancy (leiomyosarcoma) [22] a Protein-calorie malnutrition [1] Vitamin B12 deficiency [23] a a some of these etiologies can also result in lightening of the hair color…”

Section: Iatrogenicmentioning

confidence: 99%

“…Systemic causes of yellowing or lightening of hair color generally act by altering normal synthesis of melanin pigment molecules. Systemic medications are a common cause of hair color changes, and several have been implicated, including chloroquine, cisplatin, heptaminol, mephenesin, para-aminobenzoic acid (PABA), sunitinib, tamsulosin, and valproic acid [2,3,19,26]. Systemic processes known to cause lightening of hair color include metabolic or nutritional deficiencies (such as protein-calorie malnutrition-Kwashiorkor [1], essential fatty acid deficiency [21], and vitamin B12 deficiency [23]), and malignancy (leiomyosarcoma) [22].…”

Section: Etiology Of Xanthotrichosismentioning

confidence: 99%

“…In many patients, despite a thorough workup, no definitive cause of discoloration is discovered [3]. For these individuals, the follow up plan requires careful, intuitive judgement.…”

Section: Evaluation Of Individuals With Yellow Hair Discolorationmentioning

confidence: 99%

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Yellow hair following sequential application of bacitracin zinc and selenium sulfide: Report of acquired xanthotrichosis and review of yellow hair discoloration

Crowley

Cohen²

2016

Dermatology Online Journal

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BackgroundAcquired yellow hair (xanthotrichosis) can result from the deposition of pigmented compounds on the hair shaft or from chemical modification of hair pigment and protein molecules. PurposeA white-haired 77-year-old woman who developed xanthotrichosis of her scalp hair following the sequential application of bacitracin zinc ointment and selenium sulfide 2.5% lotion is described and the causes of yellow hair discoloration are reviewed. Materials and methodsThe clinical features of a woman with acquired yellow hair discoloration are presented. Using PubMed and Google Scholar, the following terms were searched and relevant citations were assessed: bacitracin zinc, hair discoloration, selenium sulfide, xanthotrichosis, and yellow hair. ResultsYellow hair was observed on the scalp in areas treated with the following regimen: prior to bedtime, several areas of the scalp were treated with a single application of bacitracin zinc ointment. The next morning, selenium sulfide 2.5% lotion was applied and then rinsed from the scalp during showering. Yellow hair discoloration was apparent in co-treated areas immediately following rinsing; the discoloration gradually faded over 2-5 days with regular shampooing. ConclusionsAcquired yellow hair shaft discoloration has been reported secondary to multiple etiologies, including environmental and occupational exposures, iatrogenic causes (including topical and systemic drugs) and protein-calorie malnutrition. To this list, we add yellow discoloration of white scalp hair due to application of selenium sulfide following topical use of bacitracin zinc in the affected areas as an unexpected adverse effect that may occur in individuals with white hair.

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Section: Introductionmentioning

confidence: 94%

Section: Iatrogenicmentioning

confidence: 99%

Section: Etiology Of Xanthotrichosismentioning

confidence: 99%

“…In many patients, despite a thorough workup, no definitive cause of discoloration is discovered [3]. For these individuals, the follow up plan requires careful, intuitive judgement.…”

Section: Evaluation Of Individuals With Yellow Hair Discolorationmentioning

confidence: 99%

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