Probable Identity of Tissue Specific Historie with Encephalitogenic Protein

No Evidence for an Immunological Cross-Reaction between Encephalitogenic Myelin Basic Protein and Histones

“…Thus, Tomasi and Kornguth [12] and Kornguth et al [7] found that antibodies to MBP of brain white matter [7,9] react with the nuclei of neurones and spermatogonia [12], These results are explained by Kornguth et al [7] by an immu nological cross-reaction between MBP and histones. Using the macro phage electrophoretic mobility (MEM) test, it was demonstrated that lymphocytes from patients with malignant neoplasms, even in its earliest state, are sensitized to basic proteins derived from central or peripheral nervous system [2] as well as to histones [6].…”

Myelin

“…2 concerning its sequence , is related to the larger protein by a deletion mutation. Partial sequence identification for pig Kornguth et al, 1972) and rat large (Martenson et al,1972) other studies. The sequence-determination studies led to tests of various peptide fragments for their ability to produce the disease in an effort to define the encephalitogenic regions of the protein.…”

Myelin

“…1 relating to its sequence (Dunkley and Carnegie,197 4), is related to the larger protein by a deletion mutation. Partial sequence identification for pig Kornguth et al, 1972) and rat large (Martenson et al, 1972) basic proteins have also been provided by other studies. The sequence determination studies led to tests of various peptide fragments for their ability to produce the disease in an effort to define the encephalitogenic regions of the protein.…”