Probable metronidazole induced serum sickness-like reaction in a paediatric patient

VanCleave, H. Z.; Sanchez, A. C.; Lieberman, Jay; Ellenburg, J. T.; Mabry, William A.

doi:10.1111/jcpt.12448

Cited by 9 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,12 However, a great variety of other drugs have been reported to trigger SSLR: sulfonamide drugs, anticancer agents, anticonvulsants, anti-inflammatory agents, griseofulvin, metronidazole, bupropion, and more recently, biological agents such as rituximab, infliximab, and efalizumab, among others. [13][14][15][16] Initial studies estimated that the incidence of SSLR in children caused by cefaclor was an estimated 0.4-0.5% of all antibiotic courses. 12 Subsequent studies reported that SSLR represents 4.0% of all adverse drug reactions associated with amoxicillin.…”

Section: Definition and Aetiologymentioning

confidence: 99%

Serum Sickness-Like Reaction in Children: Review of the Literature

Pozzo‐Magaña

Lazo‐Langner

2019

EMJ Dermatol

View full text Add to dashboard Cite

Serum sickness-like reaction (SSLR) is an acute inflammatory condition affecting children and adults characterised by the development of erythematous skin lesions and joint swelling with or without fever. Although these features resemble the ones seen in patients with classic serum sickness, the precise pathophysiology of SSLR remains unclear. It is considered that drugs, usually β-lactam antibiotics, and some infectious agents can trigger an immunologic reaction that leads to these clinical manifestations. This condition is usually under-recognised or mistakenly diagnosed as other conditions (e.g., urticaria, urticaria multiforme, reactive arthritis, erythema multiforme) and therefore infrequently reported. Until now, there was no standardised treatment for this condition and controversy regarding the use of antihistamines, nonsteroidal anti-inflammatory drugs, and oral corticosteroids remains. Most of the current literature on SSLR is based on occasional case reports series. The main objective of this manuscript is to offer an organised and updated review of the clinical features and current treatment options for paediatric SSLR, useful for physicians and other health professionals with interest in paediatrics and adverse drug reactions.

show abstract

Section: Definition and Aetiologymentioning

confidence: 99%

Serum Sickness-Like Reaction in Children: Review of the Literature

Pozzo‐Magaña

Lazo‐Langner

2019

EMJ Dermatol

View full text Add to dashboard Cite

show abstract

“…Compared with serum sickness, SSLRs do not form immune complexes, and patients have normal C3 and C4 levels because the complement system is not activated [10]. SSLRs usually develop after the administration of antibiotics such as cefaclor, penicillin, metronidazole, ciprofloxacin, and clarithromycin [11][12][13][14][15]. Vaccinetriggered SSLRs are rare, but those induced by rabies, influenza, and pneumococcal vaccines have been reported [5,6,16,17].…”

Section: Discussionmentioning

confidence: 99%

Serum Sickness-Like Reactions After Pneumococcal Vaccination

Chung¹,

Liu²,

Chen³

2021

Cureus

View full text Add to dashboard Cite

Serum sickness or serum sickness-like reactions (SSLRs) constitute a rare complication that manifests in individuals after receiving vaccinations. In this case report, we present a patient with typical symptoms of SSLRs after pneumococcal vaccination. The time course of this disease and our diagnostic process are documented in detail. The literature related to serum sickness and SSLRs is also reviewed.

show abstract

“…Other Hypersensitivity Reactions Other case reports include allergic contact dermatitis [75], fixed drug eruption [76][77][78][79], serum sickness-like reaction [80], SJS/TEN [81,82], AGEP [83,84], SDRIFE [85], and a possible case of DRESS given fever and rash but no lab studies were done to assess internal organ involvement [86].…”

Section: Ige-mediated Reactionsmentioning

confidence: 99%

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Dilley

Geng

2021

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Hypersensitivity reactions including IgE-mediated and delayed cell-mediated reactions to aminoglycosides, clindamycin, linezolid, and metronidazole are rare. For aminoglycosides, allergic contact dermatitis is the most frequent reaction for which patch testing can be a useful step in evaluation. For clindamycin, delayed maculopapular exanthems are the most common reactions. There are case reports of clindamycin associated with drug rash with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), acute febrile neutrophilic dermatosis, and symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). For linezolid, cases of hypersensitivity were exceedingly rare and included urticaria, angioedema, anaphylaxis, delayed rashes, and DRESS. For metronidazole, only rare cases were found across a broad spectrum of reactions including allergic contact dermatitis, fixed drug eruption, angioedema, anaphylaxis, serum sickness-like reaction, SJS/TEN, AGEP, SDRIFE, and a possible case of DRESS. IgE-mediated reactions and anaphylaxis to these types of antibiotics are uncommon, and reports of skin testing concentrations and desensitization protocols are largely limited to case reports and series. Non-irritating skin testing concentrations have been reported for gentamycin, tobramycin, and clindamycin. Published desensitization protocols for intravenous and inhaled tobramycin, oral clindamycin, intravenous linezolid, and oral and intravenous metronidazole have also been reported and are reviewed.

show abstract

Probable metronidazole induced serum sickness-like reaction in a paediatric patient

Cited by 9 publications

References 12 publications

Serum Sickness-Like Reaction in Children: Review of the Literature

Serum Sickness-Like Reaction in Children: Review of the Literature

Serum Sickness-Like Reactions After Pneumococcal Vaccination

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Contact Info

Product

Resources

About