Probe‐based confocal laser endomicroscopy for the diagnosis of pancreatic ductal structures

Nakaoka, Kazunori; Hashimoto, Senju; Kawabe, Naoto; Nakano, Takuji; Takamura, Tomoki; Miyachi, Sayuri; Mii, Arisa; Fukui, Aiko; Yoshioka, Kentaro; Hirooka, Yoshiki

doi:10.1111/jgh.15111

Cited by 5 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Normal endometrium of 96.7% and 93.3% for pancreatic ductal adenocarcinoma and pancreatitis, respectively [14]. The accuracy of confocal microendoscopy in the diagnosis of endometrial cancer and precancerous lesions was 96.9% in this study.…”

Section: Histology (%) Pclementioning

confidence: 46%

“…pCLE enables real-time diagnosis of organ lesions without the need for a routine invasive biopsy. This technique has many advantages in the early diagnosis of endometrial lesions: ① it can magnify human tissues and cells at a microscopic level to determine the stage and grade of endometrial lesions and aid in the detection of early and occult lesions; ② it can prevent bleeding, pain, and other complications caused by destructive and invasive biopsies; ③ it can precisely locate the lesion and facilitate routine or invasive biopsies or lesion resection [15]; ④ it enables real-time diagnosis of lesions, speeding up the management process of gynecological cancer [14]; and ⑤ it enables rapid diagnosis and simultaneous treatment of endometrial lesions for a precise removal without any damage to the surrounding normal tissues, to restore organ function as soon as possible and preserve fertility.…”

Section: Benign Endometrial Abnormalitymentioning

confidence: 99%

See 1 more Smart Citation

Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium

Wen

Yang

et al. 2022

BMC Cancer

View full text Add to dashboard Cite

Background This study observed and described the morphological characteristics of the endometrium of the resected uterus using confocal laser endomicroscopy. This included benign endometrium, non-atypical endometrial hyperplasia, atypical endometrial hyperplasia, and endometrial carcinoma, thereby laying a foundation for finding the precise localization and resection of endometrial lesions, given the feasibility of confocal laser endomicroscopy-assisted hysteroscopy. Methods This prospective study included 32 patients who underwent hysterectomy. We used confocal laser endomicroscopy to observe the endometrium of resected uteruses and described the characteristics of endometrium in different states by comparing histopathological findings (primary objects). The secondary objects of observation were the myometrium, endocervical canal, and surface of the external os of the cervix. Results A total of 32 patients who underwent hysterectomy for different diseases were included: 9 with endometrial carcinoma (5 with endometrioid carcinoma, 1 with endometrial serous carcinoma, 2 with clear cell carcinoma, and 1 with carcinosarcoma), 2 with atypical endometrial hyperplasia, 9 with benign diseases, 7 with cervical cancer, and 5 with ovarian cancer and borderline tumor. The dynamic images of the endometrium were observed and recorded using probe-based confocal laser endomicroscopy (pCLE). Considering histopathology as the gold standard, the diagnostic concordance rate of pCLE was 96.9% in patients with endometrial carcinoma and precancerous lesions and 100% in patients with endometrial carcinoma. Conclusion Confocal laser endomicroscopy provides real-time high-resolution images of the benign endometrium and endometrial lesions. Compared with histopathology, confocal laser endomicroscopy has high diagnostic accuracy and may become an auxiliary examination tool for hysteroscopy, as it is useful for early identification of endometrial lesions, real-time diagnosis of tumor, and detection of tumor boundaries for complete tumor resection. These findings can lay a foundation for the feasible use of fertility-sparing local excision of tumor lesions by hysteroscopy.

show abstract

Section: Histology (%) Pclementioning

confidence: 46%

Section: Benign Endometrial Abnormalitymentioning

confidence: 99%

Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium

Wen

Yang

et al. 2022

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…Pancreatic confocal endomicroscopy changed management in four patients, changing the type of surgery from total pancreatectomy to Whipple. Another recent study (41) described among thirty patients with pancreatic changes: The diagnostic accuracy of endomicroscopy for pancreatic cancer and pancreatitis (96.7% and 93.3%, respectively) was higher than that of cytology (76.7% and 63.3%, respectively) (P = 0.0227 and 0.0048, respectively). The endomicroscopic value of pancreatic ductal changes is still under debate because it cannot reliably rule out pancreatic cancer.…”

Section: Biliary and Pancreatic Diseasesmentioning

confidence: 92%

Diagnostic Value of Endomicroscopy for Gastrointestinal Diseases: New Possibilities and Concepts

Kießlich

2021

Techniques and Innovations in Gastrointestinal Endoscopy

View full text Add to dashboard Cite

“…The accuracy of pCLE in the diagnosis of gastrointestinal tumors has been demonstrated in previous studies 7,8 . To date, pCLE has been studied in a variety of digestive diseases, including ulcerative colitis, colorectal polyps, pancreatic disease, and Barrett's esophagus [9][10][11][12] . In the same situation, pCLE can also enter the intrahepatic and extrahepatic bile ducts to provide real-time enlarged tissue information for bile duct lesions.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Probe-Based Confocal Laser Endomicroscopy and Tissue Sampling by Endoscopic Retrograde Cholangiopancreatography in Indeterminate Biliary Strictures: A Meta‑Analysis

Mi¹,

Han²,

Wang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Probe-based confocal laser endomicroscopy (pCLE), also known as optical biopsy, is a new endoscopic technique that provides real-time magnification of 1000x microscopic tissue information to diagnose indeterminate biliary strictures. Tissue sampling by endoscopic retrograde cholangiopancreatography (ERCP) is routinely performed to evaluate indeterminate biliary strictures. To evaluate the accuracy of pCLE and tissue sampling by ERCP in the diagnosis of indeterminate biliary strictures, 18 articles were included from 2008 to 2021 through Embase, PubMed, Web of Science, and Cochrane library databases. The summary estimates for the pCLE diagnosis of indeterminate biliary strictures were: sensitivity 0.88 (95% confidence interval (CI), 0.84-0.91); specificity 0.79 (95% CI, 0.74-0.83); and Diagnostic Odds Ratio (DOR) 24.63 (95% CI, 15.76-38.48). The summary estimates for tissue sampling by ERCP diagnosis for indeterminate biliary strictures were: sensitivity 0.54 (95% CI, 0.49-0.59); specificity 0.96 (95% CI, 0.94-0.98); and DOR 11.31 (95% CI 3.90-32.82). The area under the sROC curve of pCLE diagnosis of indeterminate biliary strictures is 0.90 higher than 0.65 of tissue sampling by ERCP. The pCLE is a better approach than tissue sampling by ERCP for the diagnosis of indeterminate biliary strictures by providing real-time microscopic images of the bile ducts.

show abstract

Probe‐based confocal laser endomicroscopy for the diagnosis of pancreatic ductal structures

Cited by 5 publications

References 31 publications

Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium

Preliminary study of confocal laser endomicroscopy for in vitro specimens of the endometrium

Diagnostic Value of Endomicroscopy for Gastrointestinal Diseases: New Possibilities and Concepts

Diagnostic Accuracy of Probe-Based Confocal Laser Endomicroscopy and Tissue Sampling by Endoscopic Retrograde Cholangiopancreatography in Indeterminate Biliary Strictures: A Meta‑Analysis

Contact Info

Product

Resources

About