Probe‐based confocal laser endomicroscopy for pleural malignancies diagnosis

Bonhomme, Olivier; Heinen, Vincent; Detrembleur, Nancy; Corhay, Jean-Louis; Louis, Renaud; Duysinx, Bernard

doi:10.1111/resp.13945

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…In comparison with 105 pleural biopsies, distinctive CLE patterns for pleural tumour deposits, malignant infiltration in fat tissue and benign fibrotic pleural tissue were validated with moderate interobserver agreement [ 61 ]. The most extensive experience, however, was gained recently by performing pCLE-imaging during thoracoscopic procedures [ 62 ▪ ]. Of the 62 included patients, 36 had benign and 26 had malignant pleural disease upon histological evaluation.…”

Section: Confocal Laser Endomicroscopymentioning

confidence: 99%

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Advances in bronchoscopic optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

Kramer¹,

Wijsman²,

Kalverda³

et al. 2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewImaging techniques play a crucial role in the diagnostic work-up of pulmonary diseases but generally lack detailed information on a microscopic level. Optical coherence tomography (OCT) and confocal laser endomicroscopy (CLE) are imaging techniques which provide microscopic images in vivo during bronchoscopy. The purpose of this review is to describe recent advancements in the use of bronchoscopic OCT- and CLE-imaging in pulmonary medicine.Recent findingsIn recent years, OCT- and CLE-imaging have been evaluated in a wide variety of pulmonary diseases and demonstrated to be complementary to bronchoscopy for real-time, near-histological imaging. Several pulmonary compartments were visualized and characteristic patterns for disease were identified. In thoracic malignancy, OCT- and CLE-imaging can provide characterization of malignant tissue with the ability to identify the optimal sampling area. In interstitial lung disease (ILD), fibrotic patterns were detected by both (PS-) OCT and CLE, complementary to current HRCT-imaging. For obstructive lung diseases, (PS-) OCT enables to detect airway wall structures and remodelling, including changes in the airway smooth muscle and extracellular matrix.SummaryBronchoscopic OCT- and CLE-imaging allow high resolution imaging of airways, lung parenchyma, pleura, lung tumours and mediastinal lymph nodes. Although investigational at the moment, promising clinical applications are on the horizon.

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Section: Confocal Laser Endomicroscopymentioning

confidence: 99%

“…Several studies performed CLE-imaging for the diagnosis of pleural malignancies [60][61][62][63]. One study performed both pCLE and nCLE-imaging of the pleura during 20 diagnostic procedures, including thoracoscopy, surgical excision, ultrasound and endoscopic ultrasound [61].…”

Section: Pleural Malignancymentioning

confidence: 99%

Advances in bronchoscopic optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

Kramer¹,

Wijsman²,

Kalverda³

et al. 2022

Current Opinion in Pulmonary Medicine

View full text Add to dashboard Cite

show abstract

“…Bonhomme et al . reported 2 in a publication in Respirology the use of probe‐based confocal laser endomicroscopy (pCLE) during pleuroscopy as part of their stepwise effort to establish the usefulness of pCLE in guiding pleural tissue sampling. In 62 patients (26 with malignant pleural diseases), they demonstrated that pCLE could be used with pleuroscopes and, in selected cases, provided impressive detailed cellular images comparable to eventual histological pictures from pleural biopsies at the same site.…”

mentioning

confidence: 99%