Probe-pin device for optical neurotransmitter sensing in the brain

Kim, Min Hyuck; Song, Kyo D.; Yoon, Hargsoon; Park, Yeonjoon; Choi, Sang H.; Lee, Daesung; Shin, Kyu-Sik; Hwang, Hak-In; Lee, Uhn

doi:10.1117/12.2085610

Cited by 2 publications

(3 citation statements)

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“…Various compact spectrometers have also been developed by many other research groups such as Chaganti et al [9], Montgomery et al [10], and Kitaura et al [11]. Although most of today's spectrometers use the Fraunhofer diffraction principle, we utilized the fundamental advantage of Fresnel diffraction for miniaturization of spectrometers [12][13][14]. Additionally, we developed an electronic data acquisition unit with geometric optic modules for real time optical sensing of the brain through wireless communication.…”

Section: Microspectrometer and Probe Pin Devicementioning

confidence: 99%

“…Additionally, we developed an electronic data acquisition unit with geometric optic modules for real time optical sensing of the brain through wireless communication. Here, a bluetooth wireless communication module, and a power management unit were integrated with a PSOC-5 microcontroller [14]. An image of the optical dopamine sensing system is shown in Figure 2(a).…”

Section: Microspectrometer and Probe Pin Devicementioning

confidence: 99%

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A wirelessly powered microspectrometer for neural probe-pin device

et al. 2015

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Treatment of neurological anomalies, places stringent demands on device functionality and size. A micro-spectrometer has been developed for use as an implantable neural probe to monitor neuro-chemistry in synapses. The microspectrometer, based on a NASA-invented miniature Fresnel grating, is capable of differentiating the emission spectra from various brain tissues. The micro-spectrometer meets the size requirements, and is able to probe the neuro-chemistry and suppression voltage typically associated with a neural anomaly. This neural probe-pin device (PPD) is equipped with wireless power technology (WPT) enabling operation in a continuous manner without requiring an implanted battery. The implanted neural PPD, together with a neural electronics interface and WPT, allow real-time measurement and control/feedback for remediation of neural anomalies. The design and performance of the combined PPD/WPT device for monitoring dopamine in a rat brain will be presented to demonstrate the current level of development. Future work on this device will involve the addition of an embedded expert system capable of performing semi-autonomous management of neural functions through a routine of sensing, processing, and control.

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Section: Microspectrometer and Probe Pin Devicementioning

confidence: 99%

Section: Microspectrometer and Probe Pin Devicementioning

confidence: 99%

A wirelessly powered microspectrometer for neural probe-pin device

et al. 2015

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“…We previously presented a preliminary design of an optical dopamine sensing system, measured its outputs, and characterized its response [28,29]. Here we introduce a miniaturized wireless dopamine sensor as an integral part of a micro-spectrometer, a data acquisition unit, and a wireless data transfer module.…”

Section: Introductionmentioning

confidence: 99%

Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain

Kim

Yoon

Choi

et al. 2016

Sensors

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Real-time monitoring of extracellular neurotransmitter concentration offers great benefits for diagnosis and treatment of neurological disorders and diseases. This paper presents the study design and results of a miniaturized and wireless optical neurotransmitter sensor (MWONS) for real-time monitoring of brain dopamine concentration. MWONS is based on fluorescent sensing principles and comprises a microspectrometer unit, a microcontroller for data acquisition, and a Bluetooth wireless network for real-time monitoring. MWONS has a custom-designed application software that controls the operation parameters for excitation light sources, data acquisition, and signal processing. MWONS successfully demonstrated a measurement capability with a limit of detection down to a 100 nanomole dopamine concentration, and high selectivity to ascorbic acid (90:1) and uric acid (36:1).

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Probe-pin device for optical neurotransmitter sensing in the brain

Cited by 2 publications

References 3 publications

A wirelessly powered microspectrometer for neural probe-pin device

A wirelessly powered microspectrometer for neural probe-pin device

Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain

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