We propose a simple model to simultaneously explain four observed flavor anomalies while generating the neutrino mass at the one-loop level. Specifically, we address the measured anomalous magnetic dipole moments of the muon, ∆aμ, and electron, ∆ae, the observed anomaly of b → sl+l− in the B-meson decays, and the Cabibbo-angle anomaly. The model consists of four colorful new degrees of freedom: three scalar leptoquarks with the Standard Model quantum numbers (3, 3, −1/3), (3, 2, 1/6), and (3, 1, 2/3), and one pair of down-quark-like vector fermion in (3, 1, −1/3). The baryon number is assumed to be conserved for simplicity.Phenomenologically viable solutions with the minimal number of real parameters can be found to accommodate all the above-mentioned anomalies and produce the approximate, close to 1σ, neutrino oscillation pattern at the same time. From general consideration, the model robustly predicts: (1) neutrino mass is of the normal hierarchy type, and (2) $$ {\mathcal{M}}_{ee}^{\nu } $$
M
ee
ν
≲ 3 × 10−4 MeV.The possible UV origin to explain the flavor pattern of the found viable parameter space is briefly discussed. The parameter space can be well reproduced within a simple split fermion toy model.