Probing changes in corticospinal excitability following theta burst stimulation of the human primary motor cortex

Goldsworthy, Mitchell R.; Vallence, Ann-Maree; Hodyl, Nicolette A.; Semmler, John G.; Pitcher, Julia B.; Ridding, Michael C.

doi:10.1016/j.clinph.2015.06.014

Cited by 37 publications

(35 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, we also found highly variable MEP responses to cTBS, to both types of speech stimuli. This is in line with recent observations of highly variable MEP response profiles following cTBS (Goldsworthy et al, 2016;Hannah et al, 2016;Hordacre et al, 2016;Vallence et al, 2015;Vernet et al, 2014). Whilst progress has been made in understanding the causes of MEP (Davare, Lemon, & Olivier, 2008).…”

Section: Discussionsupporting

confidence: 89%

Modulation of intra- and inter-hemispheric connectivity between primary and premotor cortex during speech perception

et al. 2018

View full text Add to dashboard Cite

Primary motor (M1) areas for speech production activate during speechperception. It has been suggested that such activation may be dependent upon modulatory inputs from premotor cortex (PMv). If and how PMv differentially modulates M1 activity during perception of speech that is easy or challenging to understand, however, is unclear. This study aimed to test the link between PMv and M1 during challenging speech perception in two experiments. The first experiment investigated intra-hemispheric connectivity between left hemisphere PMv and left M1 lip area during comprehension of speech under clear and distorted listening conditions. Continuous theta burst stimulation (cTBS) was applied to left PMv in eighteen participants (aged 18-35). Post-cTBS, participants performed a sentence verification task on distorted (imprecisely articulated), and clear speech, whilst also undergoing stimulation of the lip representation in the left M1 to elicit motor evoked potentials (MEPs). In a second, separate experiment, we investigated the role of inter-hemispheric connectivity between right hemisphere PMv and left hemisphere M1 lip area. Dual-coil transcranial magnetic stimulation was applied to right PMv and left M1 lip in fifteen participants (aged 18-35). Results indicated that disruption of PMv during speech perception affects comprehension of distorted speech specifically. Furthermore, our data suggest that listening to distorted speech modulates the balance of intra- and inter-hemispheric interactions, with a larger sensorimotor network implicated during comprehension of distorted speech than when speech perception is optimal. The present results further understanding of PMv-M1 interactions during auditory-motor integration.

show abstract

Section: Discussionsupporting

confidence: 89%

Modulation of intra- and inter-hemispheric connectivity between primary and premotor cortex during speech perception

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Contrary to what has been observed in RAD51 +/− / MM + individuals, where mirror MEPs were elicited in no more than one‐third of TMS trials using 1.2x resting motor threshold intensity, mirror MEPs were induced in 100% of trials among DCC +/− /MM + participants using a similar stimulation intensity at rest (1 mV MEP), consistent with recent reports . Therefore, it appears that downregulating DCC, compared to RAD51, has a larger impact on the development and excitability of the ipsilateral CST.…”

Section: Discussionsupporting

confidence: 86%

Neural function in DCC mutation carriers with and without mirror movements

Vosberg

Beaulé

Torres‐Berrío

et al. 2019

Annals of Neurology

View full text Add to dashboard Cite

Objective Recently identified mutations of the axon guidance molecule receptor gene, DCC, present an opportunity to investigate, in living human brain, mechanisms affecting neural connectivity and the basis of mirror movements, involuntary contralateral responses that mirror voluntary unilateral actions. We hypothesized that haploinsufficient DCC +/− mutation carriers with mirror movements would exhibit decreased DCC mRNA expression, a functional ipsilateral corticospinal tract, greater “mirroring” motor representations, and reduced interhemispheric inhibition. DCC +/− mutation carriers without mirror movements might exhibit some of these features. Methods The participants (n = 52) included 13 DCC +/− mutation carriers with mirror movements, 7 DCC +/− mutation carriers without mirror movements, 13 relatives without the mutation or mirror movements, and 19 unrelated healthy volunteers. The multimodal approach comprised quantitative real time polymerase chain reaction, transcranial magnetic stimulation (TMS), functional magnetic resonance imaging (fMRI) under resting and task conditions, and measures of white matter integrity. Results Mirror movements were associated with reduced DCC mRNA expression, increased ipsilateral TMS‐induced motor evoked potentials, increased fMRI responses in the mirroring M1 and cerebellum, and markedly reduced interhemispheric inhibition. The DCC +/− mutation, irrespective of mirror movements, was associated with reduced functional connectivity and white matter integrity. Interpretation Diverse connectivity abnormalities were identified in mutation carriers with and without mirror movements, but corticospinal effects and decreased peripheral DCC mRNA appeared driven by the mirror movement phenotype. ANN NEUROL 2019;85:433–442.

show abstract

“…Another possible explanation for CE facilitation after pcTBS, but not CE suppression after piTBS, maybe the fact that we were biased in detecting the potentially piTBS-induced CE suppression by measuring MEPs below the testable range. In an earlier study with non-prolonged TBS, the authors found that cTBS-induced MEP inhibition is observed by measuring at higher stimulus intensities (150% RMT), while lower stimulus intensities (110% RMT) are optimal for detecting iTBS-induced MEP facilitation (Goldsworthy et al, 2016 ). Based on their results, it may be assumed that potential piTBS-induced MEP inhibition will be observed when probed with a stimulus intensity much higher than at an RMT level.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Continuous Theta Burst Stimulation of the Motor Cortex Modulates Cortical Excitability But not Pain Perception

Klírová

Hejzlar

Kostýlková

et al. 2020

Front. Syst. Neurosci.

View full text Add to dashboard Cite

Over the past decade, theta-burst stimulation (TBS) has become a focus of interest in neurostimulatory research. Compared to conventional repetitive transcranial magnetic stimulation (rTMS), TBS produces more robust changes in cortical excitability (CE). There is also some evidence of an analgesic effect of the method. Previously published studies have suggested that different TBS parameters elicit opposite effects of TBS on CE. While intermittent TBS (iTBS) facilitates CE, continuous TBS (cTBS) attenuates it. However, prolonged TBS (pTBS) with twice the number of stimuli produces the opposite effect. In a double-blind, placebo-controlled, cross-over study with healthy subjects ( n = 24), we investigated the effects of various pTBS (cTBS, iTBS, and placebo TBS) over the right motor cortex on CE and pain perception. Changes in resting motor thresholds (RMTs) and absolute motor-evoked potential (MEP) amplitudes were assessed before and at two time-points (0–5 min; 40–45 min) after pTBS. Tactile and thermal pain thresholds were measured before and 5 min after application. Compared to the placebo, prolonged cTBS (pcTBS) transiently increased MEP amplitudes, while no significant changes were found after prolonged iTBS. However, the facilitation of CE after pcTBS did not induce a parallel analgesic effect. We confirmed that pcTBS with twice the duration converts the conventional inhibitory effect into a facilitatory one. Despite the short-term boost of CE following pcTBS, a corresponding analgesic effect was not demonstrated. Therefore, the results indicate a more complex regulation of pain, which cannot be explained entirely by the modulation of excitability.

show abstract

Probing changes in corticospinal excitability following theta burst stimulation of the human primary motor cortex

Cited by 37 publications

References 33 publications

Modulation of intra- and inter-hemispheric connectivity between primary and premotor cortex during speech perception

Modulation of intra- and inter-hemispheric connectivity between primary and premotor cortex during speech perception

Neural function in DCC mutation carriers with and without mirror movements

Prolonged Continuous Theta Burst Stimulation of the Motor Cortex Modulates Cortical Excitability But not Pain Perception

Contact Info

Product

Resources

About