Probing fluid flow using the force measurement capability of optical trapping

Eom, Namsoon; Stevens, Victoria; Wedding, A. B.; Sedev, Rossen; Connor, Jason N.

doi:10.1016/j.apt.2014.06.023

Cited by 8 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glass coverslips and polydimethylsiloxane were used as the substrate and material, respectively, for preparing the flow channel based on the conventional technique described in the literature. [23][24][25] First, a photomask was prepared by using a positive photoresist (OFPR800; Tokyo Ohka Kogyo, Kanagawa, Japan). The surface of a chromium-coated cover glass was coated with the photoresist by spin-coating at 1000 r.p.m.…”

Section: Flow Channel (Microchannel) Preparationmentioning

confidence: 99%

Drag force on micron-sized objects with different surface morphologies in a flow with a small Reynolds number

Kabir

Inoue

Kishimoto

et al. 2015

Polym J

View full text Add to dashboard Cite

The lack of a suitable experimental setup and a limited number of in vitro investigations have impeded understanding of the factors that have important roles in altering the drag force acting on tiny microobjects in a fluidic medium. Here we investigated how the surface morphology affects the drag force acting on microparticles. The drag coefficient for micron-sized polymer-grafted polystyrene (PS) and negatively charged hard (silica) and soft (hydrogel) spheres were evaluated and compared with that of a PS particle. The drag coefficient of the PS particle was found to be comparable to that predicted according to the Stokes' formula for a hard sphere. By contrast, polymer-grafted PS and negatively charged hard and soft spheres showed a considerable deviation from the Stokes' formula. The drag coefficient decreased by ~60 and ~86% for the negatively charged hard and soft spheres, respectively, whereas it increased by ~20% for the polymer-grafted PS particles with respect to that of the PS particle. This work reveals the role of the surface morphology of small objects in altering the drag force acting on them; such knowledge may help elucidate the mechanism by which the surface morphology of aquatic microorganisms helps them to control the drag force, which consequently might facilitate the invention of new technologies for micromachines or microdevices.

show abstract

Section: Flow Channel (Microchannel) Preparationmentioning

confidence: 99%

Drag force on micron-sized objects with different surface morphologies in a flow with a small Reynolds number

Kabir

Inoue

Kishimoto

et al. 2015

Polym J

View full text Add to dashboard Cite

show abstract

“…However, the effect of torque and lift force is similarly important and should be considered in future research, especially in non-steady flow conditions and in non-Newtonian fluids. 53 It is also important to compare our results with the earlier study of Eom et al 45 using optical tweezers to probe the fluid flow. However, the experimental range of their study was a lot larger than the present study; thus, the effect of near-wall was not accounted for in their analysis.…”

Section: Hydrodynamic Effect Near-wall By Shear Flowmentioning

confidence: 68%

Effect of shear flow on the hydrodynamic drag force of a spherical particle near a wall evaluated using optical tweezers and microfluidics

2021

View full text Add to dashboard Cite

show abstract

“…To approximate the shear stresses, the velocimetry technique with optical tweezers reported by Eom, et al [3] and Almendarez, et al [4] is used. This technique is based on the fact that the restoring force of optical tweezers can be modeled as a spring, taking care that the optical tweezers are in its linear region (in Fig.…”

Section: Introductionmentioning

confidence: 99%

Characterization of an interstitial current model around a cancer nodule using optical tweezers.

Torres-Saucedo

Morales-Cruzado

Pérez‐Gutiérrez

2020

Supl. Rev. Mex. Fis.

View full text Add to dashboard Cite

Currently, the process of diagnosis and treatment of a patient with metastatic cancer is highly inefficient due to the complexity of the disease (metastasis is the spread of cancer cells from a primary tumor to secondary tumors at distant sites [1]). However, recent studies have shown that shear stress, caused by natural microfluidic currents, causes cancer cells to break away, spreading them to secondary sites [2] and aggravating the disease. The extent of shear stress on nodules due to microfluidic currents has not been experimentally proven. In the present study, a methodology developed to induce local shear stresses on a cancer nodule model from velocity field measurements is presented. Such methodology is based on the use of the optical tweezers velocimetry technique reported by Eom, et al. [3] and Almendarez, et al. [4]. The methodology consists on using the holographic optical tweezers velocimetry technique (i.e. multiple trapping in one domain), in order to measure, in a discretized way, the flow field at different positions, and approximate through least squares the velocity profiles; with such information, the shear stresses on the surface of the nodule model will be approximated. The methodology contributes to the understanding of metastasis process and other applications, such as: the development of thrombosis, tumor formation, stopping bleeding, etc.

show abstract

Probing fluid flow using the force measurement capability of optical trapping

Cited by 8 publications

References 19 publications

Drag force on micron-sized objects with different surface morphologies in a flow with a small Reynolds number

Drag force on micron-sized objects with different surface morphologies in a flow with a small Reynolds number

Effect of shear flow on the hydrodynamic drag force of a spherical particle near a wall evaluated using optical tweezers and microfluidics

Characterization of an interstitial current model around a cancer nodule using optical tweezers.

Contact Info

Product

Resources

About