Probing Location of Anti-TB Drugs Loaded in Brij 96 Microemulsions Using Thermoanalytical and Photophysical Approach

Kaur, Gurpreet; Mehta, S.K.

doi:10.1002/jps.23857

Cited by 20 publications

(13 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the contrary, the enhancement of the wavenumber in INH‐ and PZA‐loaded microemulsions in the o/w region leads to the fact that these drugs are probably interacting with the bound water, as both drugs are hydrophilic in nature. The partition coefficient results, DSC and fluorescence measurement, support this observation. Thus, we can firmly comment on the location of these drugs in Brij 96 microemulsion: RIF is present at interphase toward oil, INH in bound water, and PZA in free water .…”

Section: Resultssupporting

confidence: 61%

“…The detailed investigation of microstructural changes of Brij 96 microemulsions on dilution with dispersion media has been carried out in our previous results . It has been found that this nonionic microemulsion undergo a microstructural change from w/o to o/w via bicontinuous phase upon dilution at ω = 7.5 and 13.3, respectively.…”

Section: Resultsmentioning

confidence: 98%

“…The effect of change of oil, cosurfactant (alcohols), phase behavior, water solubilization, and states of water of prepared Brij 96 microemulsion has been thoroughly investigated . Keeping in view the significance of microemulsions as drug delivery vehicles, these prepared compositions have been analyzed as drug carriers for anti‐TB drugs . Differential scanning calorimetry (DSC) and fluorescence measurements have been used to elucidate the solubilization loci of these studied drugs in Brij 96 microemulsions, which were correlated with partition coefficient studies …”

Section: Resultsmentioning

confidence: 99%

“…We previously reported an in‐depth analysis of states of water and effect of dilution on Brij 96 microemulsions. Here, the main emphasis has been laid on the OH band, as it is indicative of water and surfactant head group's interactions and influence of drugs on it.…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Coencapsulation of Hydrophobic and Hydrophilic Antituberculosis Drugs in Synergistic Brij 96 Microemulsions: A Biophysical Characterization

Kaur

Mehta

Kumar

et al. 2015

Journal of Pharmaceutical Sciences

Self Cite

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Coencapsulation of Hydrophobic and Hydrophilic Antituberculosis Drugs in Synergistic Brij 96 Microemulsions: A Biophysical Characterization

Kaur

Mehta

Kumar

et al. 2015

Journal of Pharmaceutical Sciences

Self Cite

View full text Add to dashboard Cite

“…It was found that rifampicin has strong interaction with Nile red dye and pyrazinamide/isoniazid has interaction with ruthenium dichloride. Kaur & Mehta (2014).…”

Section: Niosomementioning

confidence: 95%

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

View full text Add to dashboard Cite

From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis (TB) still is a global health threat with some new emergence of resistance. This type of emergence poses a vital challenge to control TB cases across the world. Mortality and morbidity rates are high due to this new face of TB. The newer nanotechnology-based drug-delivery approaches involving micro-metric and nano-metric carriers are much needed at this stage. These delivery systems would provide more advantages over conventional systems of treatment by producing enhanced therapeutic efficacy, uniform distribution of drug molecule to the target site, sustained and controlled release of drug molecules and lesser side effects. The main aim to develop these novel drug-delivery systems is to improve the patient compliance and reduce therapy time. This article reviews and elaborates the new concepts and drug-delivery approaches for the treatment of TB involving solid-lipid particulate drug-delivery systems (solid-lipid micro- and nanoparticles, nanostructured lipid carriers), vesicular drug-delivery systems (liposomes, niosomes and liposphere), emulsion-based drug-delivery systems (micro and nanoemulsion) and some other novel drug-delivery systems for the effective treatment of tuberculosis and role of immunomodulators as an adjuvant therapy for management of MDR-TB and XDR-TB.

show abstract

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

et al. 2018

View full text Add to dashboard Cite

Microemulsions (μEs) are being exploited as a potential route for yielding an extensive range of nanoparticles of different chemical nature, shapes and sizes. Nanodrugs offer new avenues for structuring better “drug delivery systems”. In this study, an oil‐in‐water (o/w) μE formulation comprising N‐butyl acetate/polysorbate 80/ethanol/water was developed for the preparation of nanoparticles of fluoroquinolone antibiotics (FLQ‐NPs). A pseudoternary phase diagram was mapped at constant surfactant/cosurfactant (1:2), revealing improved and high loading of FLQs in an optimum μE formulation. The as‐formulated μE showed high loading of FLQs as; levofloxacin (4.20 wt.%), ciprofloxacin (3.16 wt.%), moxifloxacin (2.53 wt.%), gatifloxacin (1.36 wt.%), ofloxacin (0.70 wt.%). Fourier transform IR analysis indicated good compatibility of each FLQ drug with μE excipients. However, dynamic light scattering showed an increase in the average particle size of the μE on drug loading, indicating the accumulation of FLQ at interface layer of the micelle. Additionally, lyophilized levofloxacin (a selected antibiotic) showed long‐term stability, amorphous morphology and improved dissolution rate, inspected by scanning transmission electron microscopy, X‐ray diffraction and electronic spectroscopy, respectively. Moreover, fluorescence measurements suggested the interfacial vicinity of levofloxacin within the μE domain, which may support controlled release of drug during systemic circulation.

show abstract

Probing Location of Anti-TB Drugs Loaded in Brij 96 Microemulsions Using Thermoanalytical and Photophysical Approach

Cited by 20 publications

References 31 publications

Coencapsulation of Hydrophobic and Hydrophilic Antituberculosis Drugs in Synergistic Brij 96 Microemulsions: A Biophysical Characterization

Coencapsulation of Hydrophobic and Hydrophilic Antituberculosis Drugs in Synergistic Brij 96 Microemulsions: A Biophysical Characterization

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

Structural Insights into the Microemulsion‐Mediated Formation of Fluoroquinolone Nanoantibiotics

Contact Info

Product

Resources

About